The Action of Batyl Alcohol and Selachyl Alcohol on the one Marrow of the Guinea Pig

Osmond, Dennis G.; Roylance, Peter J.; Webb, A.J.; Yoffey, J. M.

doi:10.1159/000207341

Cited by 13 publications

(12 citation statements)

References 5 publications

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“…The alkylglycerol concentrations in the milk samples from control dams were 161.5, 173.9, and 181.4 FM/L (54, 58.2, and 60.7 pg/mL) of milk expressed on postpartum d 8, 16, and 24, respectively, during the lactation period. The alkylglycerol concentrations in the milk from the dams fed 10,50, and 250 pprn alkylglycerols increased approximately 40, 100, and 400%, respectively, compared with that in the milk of the control dams.…”

Section: Resultsmentioning

confidence: 94%

“…Concentrations of alkylglycerols in other samples were similar to the values reported previously ( 1 I). Table 1 shows the changes in the pups' body weights during lactation on postpartum d 8, 16, and 24. The pups' average growth rate was 2.37 g/d for the control group and 2.43, 2.32, and 2.25 gld for the pups from dams fed diets containing 10, 50, and 250 pprn alkylglycerols, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Admin-istration of alkylglycerol to animals stimulated hematopoiesis including erythropoiesis, thrombocytosis, and granulocytosis (14)(15)(16). Treatment of uterine cervical cancer patients who were receiving radiation therapy with alkylglycerols significantly reduced the injuries accompanying the radiation toxicity and resulted in enhanced survival rate and survival time (17).…”

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confidence: 99%

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Effects of Dietary Alkylglycerols in Lactating Rats on Immune Responses in Pups

Jadhav

1994

Pediatr Res

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Alkylglycerols (AG) arc glyceryl ether lipids and are present in human and cow's milk and the hematopoietic organs such as bone marrow, spleen, and liver. The biologic effects of AG include stimulation of blood leukocyte and thrombocyte production and activation of macrophage and anti-tumor activity. The present study was conducted to determine the effects of dietary AG in lactating rats on AG levels in milk and development of certain immune responses in the pups. Lactating rats were fed diets supplemented with various levels of AG. Milk samples were expressed from the dams and blood was collected from the pups on postpartum d 8, 16, and 24. Concentrations of AG in milk from the dams fed AG were significantly greater than those of the controls @ < 0.05). Peripheral blood granulocytes were significantly elevated in pups from the dams fed AG, but there were no differences in peripheral blood lymphocyte numbers. Plasma levels of immunoglobulins were significantly greater for IgG @ < 0.01) and IgM @ < 0.001) in pups from the dams fed AG than in the control pups. The supplementation of AG in the diets of lactating dams significantly elevated AG levels in the milk, and the increased AG in the milk subsequently stimulated certain immune responses in the pups. in the newborn depends on the prompt and precise integration of cellular and humoral immune responses. The fetus has been in a sterile intrauterine environment, and at birth, the neonate has not yet developed a mature immune system (8). To deal with the hostile extrauterine environment, the newborn immune system must accomplish an adequate immunocompetence. Migliore-Samour

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of Dietary Alkylglycerols in Lactating Rats on Immune Responses in Pups

Jadhav

1994

Pediatr Res

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“…For a long time, it has been established that injection of batyl alcohol in rats and guinea pigs increases the number of erythrocytes, leukocytes or platelets in blood [3,30]; by contrast selachyl alcohol—the mono-unsaturated analog of batyl alcohol—is devoid of such activities [30,31], while this compound showed strong anti-tumor activities.…”

Section: Discussionmentioning

confidence: 99%

Multiple Beneficial Health Effects of Natural Alkylglycerols from Shark Liver Oil

et al. 2010

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Alkylglycerols (alkyl-Gro) are ether lipids abundant in the liver of some elasmobranch fish species such as ratfishes and some sharks. Shark liver oil from Centrophorus squamosus (SLO), or alkyl-Gro mix from this source, have several in vivo biological activities including stimulation of hematopoiesis and immunological defences, sperm quality improvement, or anti-tumor and anti-metastasis activities. Several mechanisms are suggested for these multiple activities, resulting from incorporation of alkyl-Gro into membrane phospholipids, and lipid signaling interactions. Natural alkyl-Gro mix from SLO contains several alkyl-Gro, varying by chain length and unsaturation. Six prominent constituents of natural alkyl-Gro mix, namely 12:0, 14:0, 16:0, 18:0, 16:1 n-7, and 18:1 n-9 alkyl-Gro, were synthesized and tested for anti-tumor and anti-metastatic activities on a model of grafted tumor in mice (3LL cells). 16:1 and 18:1 alkyl-Gro showed strong activity in reducing lung metastasis number, while saturated alkyl- Gro had weaker (16:0) or no (12:0, 14:0, 18:0) effect. Multiple compounds and mechanisms are probably involved in the multiple activities of natural alkyl-Gro.

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“…AKG have been shown to stimulate hematopoiesis, erythropoiesis, thrombocytosis and granulocytosis in animals [23,24]. …”

Section: Alkylglycerols Studiesmentioning

confidence: 99%

An Update on the Therapeutic Role of Alkylglycerols

Iannitti

Palmieri

2010

Marine Drugs

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Scandinavian folk medicine used shark liver oil for the treatment of cancers and other ailments based on the rarity of tumors in sharks and their ability to resist infections. Shark liver oil is a source of alkylglycerols which have been studied as anti-cancer agents in several clinical trials. Moreover, alkylglycerols have been investigated for the treatment of radiation induced side effects and for their ability to boost the immune system. Several experimental studies have shown the ability of alkylglycerols to open the blood brain barrier to facilitate the access of therapeutic drugs to the central nervous system. This review covers the most important studies of alkylglycerols in both animals and humans.

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The Action of Batyl Alcohol and Selachyl Alcohol on the one Marrow of the Guinea Pig

Cited by 13 publications

References 5 publications

Effects of Dietary Alkylglycerols in Lactating Rats on Immune Responses in Pups

Effects of Dietary Alkylglycerols in Lactating Rats on Immune Responses in Pups

Multiple Beneficial Health Effects of Natural Alkylglycerols from Shark Liver Oil

An Update on the Therapeutic Role of Alkylglycerols

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