The Action of Deoxycorticosterone Acetate and of Dietary Sodium and Potassium on Skeletal Muscle Electrolyte in Adrenalectomized Rats

Human Body Composition

“…The latter authors did not find a change in total exchangeable Na or K, however. Muscle and serum Na fall, muscle K increases, and intracellular Na drops to zero (Cole, 1953). Other tissues are also affected: tendon, skin, and cartilage show a decrease in N a concentration and an increase in K concentration, as well as muscle (Kriegel and Discherl, 1964).…”

Muscle Electrolytes in Malnutrition Syndromes of Children

“…Endocrine mechanisms may be causative factors n the observed altered muscle composition in cwashiorkor, An increase in plasma aldosterone .oncentrations has been demonstrated in kwashior-<or, although not in marasmus (21), with a reduced olasma binding of aldosterone (22). However, evi-Ience from experimental animals, as well as from children receiving excessive amounts of mineralocorticoids, indicates that in potassium depletion this Ion is exchanged for sodium without changes in muscle water (23)(24)(25). The existence of a relative adrenal insufficiency has been suggested in the child with kwashiorkor ( 10), in spite of the increased plasma-free cortisol levels seen in these patients (2M.…”