The action of quinolone carboxylic acids on <i>Chlamydia trachomatis in vitro</i>

Richmond, Shirley J.; Heppleston, Carol; Bailey, Judith

doi:10.1042/bst0140503

Cited by 2 publications

(4 citation statements)

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“…Thus, the action of the MIC of ofloxacin on C. trachomatis ap pears to be lethal. These results are in agreement with the results obtained by Bailey et al [35], Heppleston et al [36], Richmond et al [37] and by Aznar et al [38], although the methods used were slightly different. The MICs for ofloxacin, ciprofloxacin and norfloxacin were very close to the results obtained by us [36][37][38].…”

Section: Discussionsupporting

confidence: 83%

“…These results are in agreement with the results obtained by Bailey et al [35], Heppleston et al [36], Richmond et al [37] and by Aznar et al [38], although the methods used were slightly different. The MICs for ofloxacin, ciprofloxacin and norfloxacin were very close to the results obtained by us [36][37][38]. Furthermore, for each of these quinolones there was little or no difference between the MIC and the MLC, whether the exper iments were performed essentially as in schedule B [35,37,38] or schedule C [36] of the present study.…”

Section: Discussionsupporting

confidence: 83%

“…Furthermore, for each of these quinolones there was little or no difference between the MIC and the MLC, whether the exper iments were performed essentially as in schedule B [35,37,38] or schedule C [36] of the present study. Thus, the MICs of these quinolones were concluded to be lethal to C. trachomatis in vitro [35][36][37],…”

Section: Discussionmentioning

confidence: 97%

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Chlamydia trachomatis: In vitro Susceptibility of Genital and Ocular Isolates to Some Quinolones, Amoxicillin and Azithromycin

Børsum

Dannevig²,

Størvold³

et al. 1990

Chemotherapy

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The minimum inhibitory concentration (MIC) of ofloxacin, ciprofloxacin, norfloxacin, amoxicillin and a new erythromycin analogue (azithromycin or CP 62993) against Chlamydia trachomatis was determined. There was a large difference between the MICs (μg/ml) of different quinolones (median of 3 independent measurements; range): ofloxacin (0.5; 0.5–1) < ciprofloxacin (1; 1–2) < norfloxacin (16; 16–32). The MIC of amoxicillin varied from 0.25 to 1 (median 0.5) in different experiments. The MIC of azithromycin (0.125; 0.063–0.25) was lower than that of erythromycin (0.25; 0.125–0.5). The minimum lethal concentration (MLC) of ofloxacin and azithromycin was determined with and without passage of the McCoy cells. Both methods gave the same results. Ofloxacin seemed to have a lethal effect on C. trachomatis, as the MIC and MLC were equal. In contrast, the effect of the MIC of azithromycin on C. trachomatis was bacteriostatic. The MLC of azithromycin was 2–4 times higher than the MIC (p < 0.001).

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 83%

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Chlamydia trachomatis: In vitro Susceptibility of Genital and Ocular Isolates to Some Quinolones, Amoxicillin and Azithromycin

Børsum

Dannevig²,

Størvold³

et al. 1990

Chemotherapy

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“…Also, infertility resulting from salpingial obstruction is considered to be frequently caused by C. trachomatis (6). Several studies have shown that some kinds of quinolone, macrolide, and tetracycline drugs are effective against C. trachomatis in vitro (1,2,7,10,(15)(16)(17)(18). We evaluated the in vitro activities of three newly developed quinolone agents, T-3262, NY-198, and fleroxacin (AM-833, RO 23-6240), against 10 clinically isolated C. trachomatis strains and compared them with those of other quinolones and minocycline.…”

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confidence: 99%

In vitro activities of T-3262, NY-198, fleroxacin (AM-833; RO 23-6240), and other new quinolone agents against clinically isolated Chlamydia trachomatis strains

Maeda

Fujii

Nakata

et al. 1988

Antimicrob Agents Chemother

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The in vitro activities of three newly developed quinolone drugs and fleroxacin ) against 10 strains of clinically isolated Chiamydia trachomatis were assessed and compared with those of other quinolones and minocycline. T-3262 (MIC for 90% of isolates tested, 0.1 ,ug/ml) was the most active of the quinolones. The NY-198 and fleroxacin MICs for 90% of isolates were 3.13 and 62.5 ,ug/ml, respectively.

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The action of quinolone carboxylic acids on Chlamydia trachomatis in vitro

Cited by 2 publications

References 0 publications

Chlamydia trachomatis: In vitro Susceptibility of Genital and Ocular Isolates to Some Quinolones, Amoxicillin and Azithromycin

Chlamydia trachomatis: In vitro Susceptibility of Genital and Ocular Isolates to Some Quinolones, Amoxicillin and Azithromycin

In vitro activities of T-3262, NY-198, fleroxacin (AM-833; RO 23-6240), and other new quinolone agents against clinically isolated Chlamydia trachomatis strains

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