The action of reserpine in imipramine-resistant depressive patients

Haskovec, L; Rysánek, K

doi:10.1007/bf00401505

Cited by 39 publications

(9 citation statements)

References 22 publications

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“…He replicated these observations in patients refractory to desipramine (DMI) (Poldinger 1963). Haskovec and Rysanek (1967) described simiOffprint requests to: L.H. Price lar findings, suggesting a possible link with serotonin (5-HT) metabolism based on increased urinary excretion of the metabolite 5-hydroxy-indoleacetic acid (5-HIAA) following reserpine.…”

supporting

confidence: 59%

“…However, BP response was highly variable. Haskovec and Rysanek (1967) found small decreases in BP and pulse, while Amsterdam and Berwish (1987) noted statistically significant decreases,…”

Section: Discussionmentioning

confidence: 99%

“…In the one prior study to examine neurobiological correlates, Haskovec and Rysanek (1967) measured 24-h urinary excretion of VMA and 5-HIAA, reflecting NE and 5-HT metabolism, respectively, before and after reserpine. 5-HIAA increased significantly during the I st day of reserpine, then decreased for at least 12 days post-treatment.…”

Section: Discussionmentioning

confidence: 99%

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Reserpine augmentation of desipramine in refractory depression: clinical and neurobiological effects

1987

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Early studies showed dramatic improvement in some depressed patients when a brief course of parenteral reserpine was added to ineffective tricyclic antidepressant (TCA) treatment. We treated eight patients with DSM-III melancholic major depression with desipramine (DMI) greater than or equal to 2.5 mg/kg/day (plasma levels greater than 125 ng/ml) for at least 4 weeks. All patients failed to respond and received reserpine 5 mg IM b.i.d. over 2 days, in seven cases as a placebo-controlled, double-blind trial. One patient had dramatic resolution of depressive and psychotic symptoms within 48 h, but relapsed within 2 weeks; two other patients had transient hypomanic symptoms. Depression ratings did not significantly change for the sample as a whole, but plasma and cerebrospinal fluid (CSF) levels of 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) decreased and CSF levels of homovanillic acid (HVA) and 5-hydroxy-indoleacetic acid (5-HIAA) increased. Despite robust effects on central monoamine metabolism, reserpine augmentation appears insufficiently effective for routine use in managing refractory depression.

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supporting

confidence: 59%

“…However, BP response was highly variable. Haskovec and Rysanek (1967) found small decreases in BP and pulse, while Amsterdam and Berwish (1987) noted statistically significant decreases,…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Reserpine augmentation of desipramine in refractory depression: clinical and neurobiological effects

1987

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“…The antidepressant response was seen within 2 days following reserpine administration [Haskovec and Rysaneck, 1967], These findings were ascertained by a double blind study [Hopkinson and Kenny, 1975]. Side effects were usually not severe and included flush ing, diarrhea, slight decreases in pulse and blood pressure, psychomotor excitation and occasional hypomania.…”

Section: Tricyclic Antidepressant Drug Interactionsmentioning

confidence: 99%

Drug Interactions in Psychiatric Practice

Ragheb¹

1981

Int Pharmacopsychiatry

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The interaction of neuroleptics, tricyclic antidepressants, monoamine oxidase inhibitors, lithium and anxiolytic sedatives with other drugs and food is reviewed with special emphasis on drug interactions commonly encountered in psychiatric practice. Clinical relevance and mechanism of action of such interactions are discussed. An update of the interaction of lithium with prostaglandin inhibitors is presented.

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“…In the other 3, no distinct improvement was apparent. Haskovec and Rysanek (1967) selected 15 depressed patients who had been on imipramine for at least 3 weeks. These patients were receiving over 300 mg of imipramine for 1 week or more without any clinical improvement.…”

Section: Combination Of Antidepressants With Reserpinementioning

confidence: 99%

Treatment of Intractable Depression

Ananth¹,

Ruskin²

1974

Int Pharmacopsychiatry

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Depression is a frequently encountered psychiatric disorder. Current methods of treatment of these syndromes range from psychotherapy, pharmacotherapy, electroconvulsive therapy and in severe refractory cases, lobotomy. Despite the usefulness of all these methods, 10-28 % of the depressed patients remain refractory to treatment (Bratfos and Haug, 1968; Greenblatt et al, 1964; Smith et al, 1969). As suicide is a relatively high risk in depressed patients, refractory patients may run even higher risk. Hence, various workers have attempted to enhance the antidepressant effects of medications by different techniques. As the basis of all these techniques remain hypothetical at this time, the conclusive evidence of the effectiveness of these methods can come from the clinical application of these techniques by the physicians in treating their intractable, depressed patients.

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The action of reserpine in imipramine-resistant depressive patients

Cited by 39 publications

References 22 publications

Reserpine augmentation of desipramine in refractory depression: clinical and neurobiological effects

Reserpine augmentation of desipramine in refractory depression: clinical and neurobiological effects

Drug Interactions in Psychiatric Practice

Treatment of Intractable Depression

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