The Action of Thyroid and Adrenal Glands on the Submaxillary Gland of Mice

Raynaud, Julien

doi:10.1016/b978-1-4832-2871-6.50010-2

Cited by 27 publications

(16 citation statements)

References 4 publications

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“…[24][25][26] The GCT phenotype of the androgen-insensitive Tfm/Y mouse is enhanced by thyroid hormones, 27 and adrenalectomy causes significant reduction of the GCT phenotype that can be restored by the injection of adrenocortical hormones. 26,28 The findings of these morphological studies are in good agreement with the results of the present study.…”

Section: Discussionmentioning

confidence: 99%

Morphologic changes in the granular convoluted tubule cells of the mouse submandibular gland following hypophysectomy and hormonal replacement

Kurabuchi

2002

Odontology

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Morphological changes in the granular convoluted tubule (GCT) cells of the male mouse submandibular gland (SMG) were examined following hypophysectomy and hormonal replacement. Semithin sections stained with Heidenhain's iron hematoxylin showed that hypophysectomy severely regressed the GCT phenotype. Although only a few dispersed cells containing secretory granules were observed in the GCT segments under a light microscope, electron microscopy revealed that many regressed cells continued to constitutively elaborate apical secretory granules (although they were very small) and contained a euchromatic nucleus at the center of the cell, poor rough endoplasmic reticulum (RER) and Golgi apparatus in the perinuclear region, and well-developed basal infoldings. These findings suggest that hypophysectomy resulted in atrophy of GCT cells, but that they retained evidence of being secretory cells. 5 alpha-Dihydrotestosterone (DHT); 3,5,3'-triiodo- l-thyronine (T(3)); and dexamethasone (Dex) each enhanced the GCT phenotype of hypophysectomized males to some degree. Combined hormonal replacement with DHT + T(3) in hypophysectomized males restored a nearly normal male GCT phenotype with a full complement of secretory granules and rare basal infoldings, whereas T(3) alone induced a normal female-like GCT phenotype, with considerably abundant secretory granules and the usual short basal infoldings, in hypophysectomized male glands. Furthermore, Dex was found to synergistically enlarge secretory granules when administered with T(3) and/or DHT, although it was only weakly effective in enhancing the GCT phenotype when used alone. Taken together, the above findings confirmed that the GCT phenotype of the mouse SMG is regulated by the synergistic action of pituitary-dependent hormones.

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Section: Discussionmentioning

confidence: 99%

Morphologic changes in the granular convoluted tubule cells of the mouse submandibular gland following hypophysectomy and hormonal replacement

Kurabuchi

2002

Odontology

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“…However, if the Tfm condition is only a genetic disease because of the lack of androgen receptors, and the natural glucocorticoid actions are normal in these mice, this will support the former hypothesis concerning the mediation of the androgen receptor. Raynaud (1964) suggested that the granular duct cell of the mouse submandibular glands is affected not only by androgens but also by thyroxine and cortisol. Similar androgenic effects of tri-iodothyronine have been found in submandibular glands of mice, but these effects have also been observed in Tfm mice (Hosoi, Kobayashi, Ueha, Maruyama, Sato, Takuma & Kumegawa, 1979).…”

Section: Discussionmentioning

confidence: 98%

“…Histochemical components in the granular duct cell, like tryptophan as demonstrated with /7-dimethylaminobenzaldehyde, also increased toward the normal male level following administration of androgens to castrated mice (Sato, Maruyama, Chen, Ebina & Tsuji, 1977). Raynaud ( 1964) observed that adrenalectomy decreases the duct size in submandibular glands of castrated mice, and that the administration of cortisol restores them to the size measured after castration. Sato & Miyata (1973) found an increasing effect of cortisol on the positive substance of the periodic acid-Schiff reaction in the duct cell and a hypertrophy of the ducts of the submandibular gland in female but not in male mice.…”

Section: Introductionmentioning

confidence: 89%

Androgenic Action of Glucocorticoids on the Granular Ducts of Mouse Submandibular Glands

Sato¹,

Maruyama²,

Azuma³

1981

Journal of Endocrinology

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The administration of cortisol acetate and dexamethasone to castrated-adrenalectomized mice increased the submandibular gland weight, the granular duct cell size of the gland and the number of androgen-dependent granules detected with the staining for tryptophan in the duct cell. These changes were not as pronounced as when testosterone propionate was given. Similar effects on the duct cells and an increase in androgen-dependent esteroprotease activity of the submandibular glands were observed in castrated mice, but not in mice with testicular feminization which are genetically deficient in androgen receptors. These results suggest that glucocorticoids exert a certain degree of androgenic action on the granular duct cell through androgen receptors when androgens are absent or deficient.

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“…It has been reported that glucocorticoids (CORT) accelerate the branching of epithelial cords during the development of the submandibular gland [Jaskoll et al, 1994[Jaskoll et al, , 1998]. Adrenalectomy in mice causes significant reduction in GCT cells, which can be reversed by replacement of adrenocorticoids [Raynaud, 1964;Sato et al, 1981;Steidler and Reade, 1982]. However, the effect of CORT on developing parenchymal cells remains unclear, particularly with regard to the differentiation of cells forming the terminal tubules and the properties of the secretory granules produced by the cells.…”

Section: Introductionmentioning

confidence: 99%

Effect of Glucocorticoid on the Differentiation and Development of Terminal Tubules in the Fetal Rat Submandibular Gland

Inukai

Ikeda²,

Aiyama³

2007

Cells Tissues Organs

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Glucocorticoids (CORT) are known to promote branching of the epithelial cords during the development of the rat submandibular gland. The aim of this study was to examine the effect of CORT (triamcinolone) on the differentiation of cells forming the terminal tubules in the developing fetal rat submandibular gland and the properties of the secretory granules. Light and electron microscopy showed that the terminal tubules of the glands in the experimental group contained more type III cells, which have been identified as proacinar cells, than those in the control group, whereas the relative number of type I cells, which have been identified as terminal tubule cells, was reduced. Immunoelectron microscopy using an antibody against neonatal submandibular gland secretory protein B (SMGB) revealed the presence of more gold particles over type III cell granules in the experimental group than in the control group. Lectin histochemistry demonstrated more wheat germ agglutinin (WGA)-labeled gold particles over type III cell granules in the experimental group than in the control group. These findings suggest that CORT promote the differentiation of type III cells, and moreover stimulate the production of secretory granules reactive for SMGB and WGA by acting on the terminal tubules of the developing rat submandibular gland.

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The Action of Thyroid and Adrenal Glands on the Submaxillary Gland of Mice

Cited by 27 publications

References 4 publications

Morphologic changes in the granular convoluted tubule cells of the mouse submandibular gland following hypophysectomy and hormonal replacement

Morphologic changes in the granular convoluted tubule cells of the mouse submandibular gland following hypophysectomy and hormonal replacement

Androgenic Action of Glucocorticoids on the Granular Ducts of Mouse Submandibular Glands

Effect of Glucocorticoid on the Differentiation and Development of Terminal Tubules in the Fetal Rat Submandibular Gland

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