The Actions of Dopamine on the Blood Pressure and Heart Rate of Conscious Hypertensive Rats: Evidence for Reduced Dopaminergic Activity in Rats of the Japanese Strains

Abstract

The effects of intracerebroventricularly (icv) and intravenously (iv) administered dopamine (DA) on mean arterial pressure (MAP) and heart rate were investigated in conscious spontaneously hypertensive rat (SHR), stroke-prone SHR (spSHR) and normotensive Wistar-Kyoto (WKY) rat of Japanese strains, genetically hypertensive (GHR) and normotensive (NT-NZ) rat of New Zealand strains, Sprague-Dawley (SD) rat, and left renal artery stenosed hypertensive WKY (WKYLRAS) and SD (SDLRAS) rats. Icv DA (0.0125-0.4 mg/kg) caused a linear dose-related decrease in MAP, accompanied by bradycardia in all animals. By contrast, the same doses of DA given iv caused a linear dose-related increase in MAP, accompanied by reflex bradycardia in most groups (except the spSHR, SHR and WKYLRAS where tachycardia occurred to most of the doses employed), indicating that the decrease in MAP following icv DA is centrally-mediated. A "greater" relative hypotensive effect to icv DA was seen in the Japanese hypertensive strains SHR and spSHR compared to the WKY, but not between the New Zealand strains or the renal hypertensive animals. Our data also show that this marked hypotensive responsiveness is not related to the basal MAP, but appears to be strain-specific. It is thus possible that the alleged reduced central dopaminergic activity in the Japanese strains of hypertensive rats may be responsible for exaggerated hypotensive responses observed in these strains.

Apis Mellifera Venom and Melittin Block neither NF-κB-p50-DNA Interactions nor the Activation of NF-κB, Instead They Activate the Transcription of Proinflammatory Genes and the Release of Reactive Oxygen Intermediates

“…Aside from histamine and MCP that account for all of the obvious undesired effects, most of the components of BV have clearly been associated with detrimental effects. Dopamine, among other undesired properties, affects the heart rate and increases the blood pressure (8); apamin can act as a potent neurotoxin (9,10), but also functions as a K ϩ channel blocker that interferes with NO-induced contractile activity of the myometrium (11). Hyaluronidases degrade, among other things, the protective hyaluronan coating of cells and contribute to the generation of undesired hyaluronan fragments (12).…”