The activation of cellular genes in transformed cells

Abstract

We have used differential cDNA cloning techniques to isolate a number of genes that are activated as a result of transformation by the DNA tumour virus Simian virus 40. From the nucleotide sequences of the cDNA clones we have been able to identify some of these genes. One of them derives from the major histocompatibility complex and contains a repetitive element that identifies a large number of RNAs present in pluripotential embryonic cells.

Regulation of a multigenic invasion programme by the transcription factor, AP-1: re-expression of a down-regulated gene, TSC-36, inhibits invasion

“…The technology of isolating genes based upon their di erential expression (Rigby et al, 1984) has been radically improved (Diatchenko et al, 1996;Eisen and Brown, 1999;Hubank and Schatz, 1994;Liang and Pardee, 1997;Velculescu et al, 1995), as has the ability to identify those di erentially expressed genes through searches of the expanding nucleic acid and amino acid sequence databases. The analysis of multiple di erentially expressed genes has led to the discovery of coordinately regulated genes, which function in distinct programmes that are regulated by given stimuli or transcription factors (Ferea et al, 1999;Iyer et al, 1999;Lut®yya et al, 1998;Myers et al, 1999;Polyak et al, 1997).…”