The active compound of soursop leaf extract (Annona muricata, L.) as anti-vaginal discharge (Fluor albus)

Abstract

The aims of this study is to determine the effectiveness of antifungal Soursop leaf extract against the fungus Candida albicans and determine the class of compounds that act as vaginal discharge. Soursop leaf was extracted using maceration method with 96% ethanol solvent then concentrated with a rotary evaporator. The class determination of active compound by using multilevel composition fractionation method with n-hexane, chloroform, and ethyl acetate solvent. The effectiveness test of antifungal of each fraction toward Candida albicans by diffusion method is so that the researcher can look at the inhibitory zone diameter, then identify them by using UV-VIS and FTIR spectrophotometry to determine the active compound as antifungal. The highest antifungal effectiveness of soursop leaf active compounds was the n hexane fraction with inhibition diameter 23.7 mm which was categorized as strong, compared to the positive control of ketoconazole with inhibition zone 22.5 mm and nystatin 15, 9 mm. The compound which is thought to have antifungal activity from the n- hexane fraction of soursop leaves is a terpenoid compound.

The morphology of polyvinylpyrrolidone nanofibers containing Anredera cordifolia leaves

“…The widening of the peak at 3331 cm -1 , 2871 cm -1 shows the O-H group stretching of the hydroxyl group (Rustanti & Fatmawati, 2020). The C-H stretching of the alkane group and the C=O stretching of the carbonyl group were shown by peaks at 2879 cm -1 and 1646 cm -1 (Rustanti & Fatmawati, 2020). This wave peak pattern confirms the presence of flavonoid chemical compounds in BLE (Rahma et al, 2016;Sriyanti et al, 2018).…”

“…The peaks of Anredera cordifolia leaves were recorded at 3331, 2971, 2879, 1646, 1380 cm -1 . The widening of the peak at 3331 cm -1 , 2871 cm -1 shows the O-H group stretching of the hydroxyl group (Rustanti & Fatmawati, 2020). The C-H stretching of the alkane group and the C=O stretching of the carbonyl group were shown by peaks at 2879 cm -1 and 1646 cm -1 (Rustanti & Fatmawati, 2020).…”

Leukorea Pada Akseptor Kontrasepsi Hormonal dengan Ekstrak Rebusan Daun Sirsak dan Sirih Merah di PMB Ny “C” Desa Mojokrapak Kabupaten Jombang

“…Alkaloid memiliki sifat antimikroba serta minyak atsiri berperan sebagai anti bakteri dan Tanin yang juga mempunyai daya anti bakteri dan ekstrak etanol daun sirih merah menunjukkan antitrichomonas dan semakin besar konsentrasi ekstrak yang digunakan maka semakin banyak jumlah sel Trichomonas vaginalis yang mati. Cara merebus 10 gram daun sirih merah dan daun sirsak dalam 500 ml (Rustanti, 2020) Daun sirsak dapat untuk mengobati keputihan pada wanita karena mengandung zat antiseptik yang dapat membunuh kuman, yaitu fenol, dimana kandungan fenol dalam daun sisak memiliki sifat antiseptik 5 kali lebih efektif dibandingkan fenol biasa, untuk mengobati keputihan rebus 10 daun sirsak dalam 2,5 liter air, kemudian rebusan yang masih hangat tersebut untuk mencuci vagina (5). atau 500 gram daun sirsak dama 1000 ml mengandung senyawa terpenoid yang mampu menghambat pertumbuhan jamur 10.…”

“…Daun Sirsak juga mempunyai banyak kegunaan, antara lain sebagai antibakteri, antifungi, antitumor, anti konvulsan, penenang, antiparasit, dan ardiodepresant. Daun sirsak mengandung alkaloid, polifenol, terpen, acetogenin, flavonoid dan lectin (Rustanti E, 2020). daun sirsak mengandung senyawa triterpenoid yang diduga memiliki sifat sebagai antijamur.…”

The Effectiveness of Crocatum Piper and Annona Muricata L Leaves Toward Leukorrhea in Hormonal Contraception Acceptors in the Working Area of Regional Public Service Agencies of Public Health Center in Tembelang

“…The damage to the cell membrane will disrupt the integrity of cellular components and cause the fungal respiration process to not occur. In the end, it results in insufficient energy for the active transport of nutrients so that fungal growth is disrupted [6].…”