The Activity of the Lipoprotein Lipase and Estrogens

Fabian, Eric; Stork, A; Kobilková, J; Sponarová, J

doi:10.1159/000458211

Cited by 26 publications

(8 citation statements)

References 8 publications

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“…The effect of sex hormones on lipoprotein lipase activity has been limited to the study of the enzyme present in postheparin plasma (4,5,10,11). These studies have been carried out mainly in the human (4,5,10,11).…”

Section: Discussionmentioning

confidence: 99%

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The effect of estrogen on the lipoprotein lipase activity of rat adipose tissue.

Hamosh¹,

Hamosh²

1975

J. Clin. Invest.

159

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Section: Discussionmentioning

confidence: 99%

“…These studies have been carried out mainly in the human (4,5,10,11). Postheparin lipolytic activity is a mixture of enzymes containing lipoprotein lipase of extrahepatic origin and triglyceride lipase of hepatic origin (12).…”

Section: Discussionmentioning

confidence: 99%

The effect of estrogen on the lipoprotein lipase activity of rat adipose tissue.

Hamosh¹,

Hamosh²

1975

J. Clin. Invest.

159

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“…Estrogeninduced hyperlipemia was thought to reside in impaired peripheral tissue removal of triglyceride, a conclusion based on the suppressive effects of natural and synthetic estrogens on plasma postheparin lipolytic activity, PHLA (6,7).' More recent studies suggest that peripheral removal is actually normal in these instances (8,9).…”

Section: Introductionmentioning

confidence: 99%

“…Some of the discrepancies between activities in plasma and tissues, then, may be caused by uncontrollable differences in levels of these cofactors in the plasma assay system. 6 Differential actions of sex steroids on tissue LPL activities may also relate to indirect effects of estrogen or P on other hormones which may have an influence on specific tissue LPL activities. For example, increased 8In the presence of increasing amounts of serum from rats treated with E or E+P, adipose LPL activities are progressively suppressed (40).…”

Section: Introductionmentioning

confidence: 99%

Sex steroid influence on triglyceride metabolism.

Kim¹,

Kalkhoff²

1975

J. Clin. Invest.

156

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A B S T R A C T Triglyceride metabolism was investigated in groups of fed and fasted rats after 21 days of parenteral estradiol (5 gg daily), progesterone (5 mg daily), or the two steroids in combination. Results were compared with control groups receiving an oil solvent alone. In rats given estradiol separately or combined with progesterone, hypertriglyceridemia was uniformly associated with increased plasma triglyceride entry, estimated with the i.v. Triton WR1339 technique. Progesterone alone had no effect on these parameters.Plasma postheparin lipolytic activity (PHLA), adipose, mammary gland, and protamine-resistant lipoprotein lipases (LPL) were significantly increased in progesterone-treated rats and significantly decreased in rats receiving estradiol with the exception of mammary gland LPL, which was also increased to a slight extent. The combined regimen reduced plasma PHLA and increased protamine-resistant, adipose, and mammary gland LPL activity.Sex steroid treatments had minimal effects on plasma glucose and free fatty acid concentrations, but all increased plasma insulin significantly. Hyperinsulinemia did not parallel changes in body weight or other measured parameters. Linear regression analyses revealed that plasma triglyceride concentrations in all fed, treated rats correlated significantly with triglyceride entry but not very uniformly with plasma or tissue LPL activity.We conclude that estradiol, unlike progesterone, has substantial lipemic effects in the rat which relate best to triglyceride entry. Hyperinsulinemia, changes in body weight, plasma PHLA, and tissue LPL activities did not consistently predict the influence of sex steroid treatment on plasma triglyceride concentrations.

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“…A number of diseases where LPL activities have been reported to be low include cystic fibrosis of pancreas, coeliac disease (Slack et al, 1962;Jakovcic and Hsia, 1963) and biliary cirrhosis (Datta, 1963;Fabian et al, 1967).…”

Section: Commentsmentioning

confidence: 99%

Lipoprotein lipase activity in marasmic type of protein-calorie malnutrition.

Gürson¹,

Saner²

1969

Archives of Disease in Childhood

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Kwashiorkor and marasmus constitute the two major syndromes of protein-calorie malnutrition encountered in infants and young children in many parts of the world.The clinical and metabolic characteristics of these syndromes differ significantly from one another, one difference being the fat metabolism. The increase of free fatty acids (FFA) in plasma has been accepted as the key factor causing fatty liver in kwashiorkor (Korn, 1955;Feigelson et al., 1961;Lewis et al., 1964;Fletcher, 1966;Bar-on and Stein, 1968 Heparin tests. After a fasting period of 12 hours, 12 U/kg. of heparin was administered intravenously. Blood was collected before and at the 15th, 45th, 60th, and 90th minutes after the administration of heparin. Plasma LPL activity, FFA, and glucose levels were determined within one hour of the collection.FFA in plasma were determined according to Dole's method as modified by Burns (Dole and Meinertz, 1960;Burns et al., 1963). Kern's method was used in the determination of LPL activity, details of which were given previously (Kern, Steinmann, and Sanders, 1961; Giirson and Etili, 1968). LPL activity was expressed as the amount of FFA in pEq/ml. per 60 min.produced from the substrate. A glucose oxidase method was used to determine blood glucose (Marks, 1959).Pilocarpine iontophoresis was carried out on all cases in this series.The statistical validity of the results was investigated by using the Student test. Half-life, zero time, extrapolated activity, and K slope constants were calculated in accordance with Boberg and Carlson's formulae (Boberg and Carlson, 1964). ResultsThe mean LFL activity in normal controls was found to be 0-298±0-167 ,uEq/ml. per 60 min. The mean values after heparin at 15, 45, 60, and 90 minutes were 4-013±0-894, 1-289±0-491, 0 544±0 343, and 0-399±0-319 ,uEq/ml. per 60 min., respectively.In cases of marasmus, the results of the first tests were as follows: the mean initial value was 0404±0 299 ,tEq/ml. per 60 min. The values after heparin were 2-125±0-916, 0-678±0-432, 0-469±0 263, and 0 325±0 247 ,uEq/ml. per 60 min. at the 15th, 45th, 60th, and 90th minutes.When the tests were repeated on 9 of the cases 6 weeks later, the mean initial value for LPL activity was found to be 0)294±0t128 ,tEq/ml. per 60 min. and the values after heparin at the same time intervals as above were 2-221±0-964, 087440-470, 0 473±0 208, and 0*270±0 129 ptEq/ml. per 60 min., respectively.

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The Activity of the Lipoprotein Lipase and Estrogens

Cited by 26 publications

References 8 publications

The effect of estrogen on the lipoprotein lipase activity of rat adipose tissue.

The effect of estrogen on the lipoprotein lipase activity of rat adipose tissue.

Sex steroid influence on triglyceride metabolism.

Lipoprotein lipase activity in marasmic type of protein-calorie malnutrition.

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