The acute effect of amylin and salmon calcitonin on energy expenditure

Wielinga, Peter Y.; Alder, B.; Lutz, Thomas

doi:10.1016/j.physbeh.2007.02.012

Cited by 53 publications

(91 citation statements)

References 22 publications

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“…Th e anorectic action of amylin has been found to be mediated by decreasing the expression of orexigenic neuropeptides (Lutz 2009). Th e eff ect of chronic administration of amylin in increasing energy expenditure has been demonstrated (Wielinga et al 2007). Acute administration of amylin agonist, salmon calcitonin but not amylin signifi cantly stimulated energy expenditure in fasted animals (Roth et al 2006).…”

Section: Role Of the Gastrointestinal Tract Peptidesmentioning

confidence: 99%

Central and peripheral control of food intake

Abdalla

2017

Endocrine Regulations

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Th e maintenance of the body weight at a stable level is a major determinant in keeping the higher animals and mammals survive. Th e body weight depends on the balance between the energy intake and energy expenditure. Increased food intake over the energy expenditure of prolonged time period results in an obesity. Th e obesity has become an important worldwide health problem, even at low levels. Th e obesity has an evil eff ect on the health and is associated with a shorter life expectancy. A complex of central and peripheral physiological signals is involved in the control of the food intake. Centrally, the food intake is controlled by the hypothalamus, the brainstem, and endocannabinoids and peripherally by the satiety and adiposity signals. Comprehension of the signals that control food intake and energy balance may open a new therapeutic approaches directed against the obesity and its associated complications, as is the insulin resistance and others. In conclusion, the present review summarizes the current knowledge about the complex system of the peripheral and central regulatory mechanisms of food intake and their potential therapeutic implications in the treatment of obesity. Th e maintenance of the body weight at a stable level is a major determinant in keeping the higher animals and mammals survive (Jequier and Tappy 1999). As a compensatory mechanism, hunger increases and energy expenditure decreases the weight loss. However, opposite responses are triggered when body weight increases. Body weight can change only when energy intake is not equal to energy expenditure over a given period of time (Bray et al. 2012). A complex physiological control system is involved in the maintenance of the energy balance. Th is system includes aff erent signals from the periphery about the state of the energy stores and eff erent signals that affect the energy intake and expenditure (Sandoval et al. 2008). Th is regulatory system is formed by multiple interactions between the gastrointestinal tract (GIT), adipose tissue, and the central nervous system (CNS). It is infl uenced by behavioral, sensorial, autonomic, nutritional, and endocrine mechanisms (Boguszewski et al. 2010). Satiety and adiposity signalsTh e food intake control includes a short-term regulation, which determines the beginning and the end of a meal (hunger and satiation) and the interval between the meals (satiety) and a long-term regulation with factors (signals of adiposity), which help to regulate the body energy depots (Cummings and Overduin 2007).Th e satiation means a suppression of the hunger and termination of the food intake aft er ingestion of Unauthenticated Download Date | 5/11/18 9:54 AM

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Section: Role Of the Gastrointestinal Tract Peptidesmentioning

confidence: 99%

Central and peripheral control of food intake

Abdalla

2017

Endocrine Regulations

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“…The amylin receptor antagonist AC187 (R&D Systems, Minneapolis, MN, USA) was dissolved in aCSF. Dose responses for drugs were selected from the literature (Hayes et al, 2011;Lutz et al, 2000;Mollet et al, 2004;Rushing et al, 2001Rushing et al, , 2000Wielinga et al, 2007).…”

Section: Drugsmentioning

confidence: 99%

Amylin Receptor Signaling in the Ventral Tegmental Area is Physiologically Relevant for the Control of Food Intake

Mietlicki‐Baase

Rupprecht

Olivos

et al. 2013

Neuropsychopharmacol

116

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The ability of amylin, a pancreatic b-cell-derived neuropeptide, to promote negative energy balance has been ascribed to neural activation at the area postrema. However, despite amylin binding throughout the brain, the possible role of amylin signaling at other nuclei in the control of food intake has been largely neglected. We show that mRNA for all components of the amylin receptor complex is expressed in the ventral tegmental area (VTA), a mesolimbic structure mediating food intake and reward. Direct activation of VTA amylin receptors reduces the intake of chow and palatable sucrose solution in rats. This effect is mediated by reductions in meal size and is not due to nausea/malaise or prolonged suppression of locomotor activity. VTA amylin receptor activation also reduces sucrose selfadministration on a progressive ratio schedule. Finally, antagonist studies provide novel evidence that VTA amylin receptor blockade increases food intake and attenuates the intake-suppressive effects of a peripherally administered amylin analog, suggesting that amylin receptor signaling in the VTA is physiologically relevant for food intake control and potentially clinically relevant for the treatment of obesity.

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“…Thus, RQ might be an instantaneous indicator of the type of nutrients that are being metabolized in a living animal. Not surprisingly, the use of RQ has proven to be a valuable technique in, for instance, studies of human obesity (Valtueña et al, 1997;Wielinga et al, 2007), as an indicator of metabolic switches in hibernating animals (Buck and Barnes, 2000) and hypoxia adaptation in invertebrates (Nielsen and Christian, 2007). However, whether RQ is a consistent property of individuals or depends totally on a response to an environmental factor (i.e.…”

Section: Introductionmentioning

confidence: 99%

Bioenergetics and inter-individual variation in physiological capacities in a relict mammal – the Monito del Monte (Dromiciops gliroides)

Cortés

Pérez

Nespolo

2009

Journal of Experimental Biology

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SUMMARYIn evolutionary physiology, studies of inter-individual variation (i.e. repeatability) in functional capacities are valuable as they indicate -within populations -what attributes could respond to natural selection. Although repeatability and quantitative genetics of physiological traits in energy metabolism of eutherian mammals have been well characterized, few or no studies have been performed on marsupials. We studied the repeatability (i.e. intraclass correlation coefficient, τ) of bioenergetics for Monito del Monte (Dromiciops gliroides), the sole living representative of an otherwise extinct marsupial order (Microbiotheria). We measured resting metabolic rate as CO 2 production (V CO2 ) and O 2 consumption (V O2 ) simultaneously, together with minimum thermal conductance (C), evaporative water loss (EWL) and respiratory quotient (RQ), in a sample of ca. 20 individuals. Our results suggest that D. gliroides exhibits poor control of body temperature (T b ), with a thermal amplitude of ca. 10°C in normothermia. As a consequence, repeatability of T b and metabolic rate (either as V CO2 or V O2 ) were relatively low (τ Tb =0.25±0.04, τ VCO2 =0.14±0.03, τ VO2 =0.24±0.02, jackknife estimations of standard errors). Thermal conductance exhibited near-zero or negative repeatability and was lower than expected for marsupials. However, we found significant repeatability for RQ and EWL (τ=0.32±0.03 and 0.49±0.09, respectively). In general, these results suggest that Monito del Monte exhibits some ʻreptilianʼ physiological characteristics. The relatively low repeatability of physiological variables, which otherwise exhibit large inter-individual and genetic variance in eutherian mammals, suggests that these capacities do not exhibit evolutionary potential in the ancient order Microbiotheria.

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The acute effect of amylin and salmon calcitonin on energy expenditure

Cited by 53 publications

References 22 publications

Central and peripheral control of food intake

Central and peripheral control of food intake

Amylin Receptor Signaling in the Ventral Tegmental Area is Physiologically Relevant for the Control of Food Intake

Bioenergetics and inter-individual variation in physiological capacities in a relict mammal – the Monito del Monte (Dromiciops gliroides)

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