The Acute Hypoxic Episode

Sadove, Max S.; Wyant, Gordon M.; Gittelson, Lloyd A.

doi:10.1136/bmj.2.4830.255

Cited by 9 publications

(4 citation statements)

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“…D. P., King, E. J., and Smith, J. M. (1951 The therapeutic value of dehydration therapy following an acute hypoxic episode has been demonstrated in cases of cardiac arrest by Sadove et al (1953). They suggest that once the heart has been restarted and an adequate oxygen supply to the brain ensured, an active regimen should be instituted to combat the cerebral oedema which occurs, and which is a direct result of hypoxic damage to the cerebral capillaries.…”

Section: Routine Medical Examinationsmentioning

confidence: 99%

“…Concentrated human serurn is suggested by Lucas (1950) and Cole (1951); Seldon et al (1949) used 25% serum albumin; Sadove et al (1953) suggest doubleor quadruplestrength plasma on account of its ready availability, but against this must be weighed the risk of serum jaundice.…”

Section: Routine Medical Examinationsmentioning

confidence: 99%

“…)d response in the patient's condition must not make get that all the tissues have been equally insulted anoxia or hypoxia, and care must be taken that an position is not adopted too quickly or severe cardiocollapse will occur. In patients who, although are still comatosed, Sadove et al (1953) recommend head-down tilt at approximately 7 degrees as being )r drainage of secretions without causing congestion brain. Additional treatment-consisting of adequate and oxygenation, prevention of acute dilatation of nach, maintenance of blood pressure, restriction of nd administration of antibiotics-is fully dealt with paper.…”

Section: Treatmentmentioning

confidence: 99%

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Cerebral Hypoxia: Aetiology and Treatment

Argent¹,

Cope²

1956

BMJ

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Section: Routine Medical Examinationsmentioning

confidence: 99%

Section: Routine Medical Examinationsmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Cerebral Hypoxia: Aetiology and Treatment

Argent¹,

Cope²

1956

BMJ

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“…In 1953, Sadove et al (1) described their concept of a "dehydration therapy" which had been worked out by that group. They had found that the administration of hypertonic 50 per cent dextrose solution did in fact accelerate the waki.r~g-up l~rocess of patients who had been in cardiac arrest 9 However, they found tl)at this state was not a permanent one, and that "rebound oedema" usually cauged some regression in the state of consciousness following inidal improvement.…”

mentioning

confidence: 99%

The management of acute hypoxia

Wyant

1960

Can. Anaes. Soc. J.

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ACUTE HYPOXIA may develop in a large variety of medical and surgical conditions. It may range from relatively mild or short-lasting episodes to the ultimate in severity as exemplified' by ventricular fibrillation and cardiac standstill. The subject of acute hypoxia has been dealt with extensively in the literature, but the main emphasis usually has been laid on cardiac arrest. Yet, any condition or event, affecting either respiration or circulation or both, which hcutely leads to suboxygenation of tissues constitutes acute hypoxia.While it can be readily appreciated that t]he diverse causes of acute hypoxia and their combination are legion, it is equally clear that, either because of the mild degree or because of extremely short duration, obvious clin/ical signs and ,sequelae may be entirely absent or at least they cannot be detected with the diagnostic means at our disposal. "Hence, from a practical point of view, such hypoxic events are of little significance.On the other hand, cardiac arrest is by no means the only acute hypoxic episode in which sequ.elae of hypoxia are present and need vigorous treatment. All too often treatment for one of the less dramatic hypoxic events is not instituted and the fact is accepted that the patient will regain consciousness less promptly than might be expected otherwise, that he will be confused, nauseated, or restless. This applies equally to anaesthesia, diver,~e states of unconsciousness, and hypoxia not associated with coma. It behoves us then in all cases of acute hypoxia to weigh the severity and duration of the event and decide whether for a particular patient nnder the particular circumstances prevailing the hypoxia was severe enough in degree and duration to merit active treatment.An attempt will be made to describe the management of severe h'ypoxia.TREATMENT (a) It is a general principle that whenever an untoward reacti~m occurs from whatever cause, the first step must be to correct that cause if it is known. This same principle applies to the management of acute hypoxia. If at ~11 possible the aetiological factor responsible for the hypoxia must be identified[and corrected and a determined effort must be made to provide adequate tissue oxygenation.(b) Because of its great intolerance to deprivation of oxygen, the central nervous sytem, and in particular the brain, present the most formldable obstacle to satisfactory recovery from acute hypoxia. The crudeness of our tests prevents us from ascertaining minor degrees of cerebral imp~drment while in extreme cases

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Acute Hypoxia

Busby

1968

Space Clinical Medicine

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The Acute Hypoxic Episode

Cited by 9 publications

References 1 publication

Cerebral Hypoxia: Aetiology and Treatment

Cerebral Hypoxia: Aetiology and Treatment

The management of acute hypoxia

Acute Hypoxia

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