The Acute Monocytic Leukemias

Dj, Straus; Mertelsmann, Roland; Koziner, Benjamín; McKenzie, Susan; E, de Harven; Za, Arlin; Kempin, Sanford; Broxmeyer, Hal E.; Ma, Moore; Cj, Menendez-Botet; Gee, TS; Clarkson, BD

doi:10.1097/00005792-198011000-00002

Medicine

1980

DOI: 10.1097/00005792-198011000-00002

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The Acute Monocytic Leukemias

Straus Dj

Roland Mertelsmann

Benjamín Koziner

et al.

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1986

1992

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Cited by 53 publications

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Aleukemic Leukemia Cutis

Hansen¹,

Barnett²,

Hanson³

et al. 1986

Arch Dermatol

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A 46-year-old man presented with nodular skin lesions, a biopsy specimen of which demonstrated a poorly differentiated malignancy. Touch preparations with histochemical staining and electron microscopy confirmed leukemia cutis. Results from a bone marrow aspirate disclosed focal areas of increased myeloblasts, and cytogenetic analysis revealed an abnormal karyotype as follows 46,XY, t(1;2) (q44p13). Antileukemic therapy resulted in prompt disappearance of the skin nodules, and a return of the patient's bone marrow to normal was noted, but after six months of intensive chemotherapy leukemia cutis recurred without morphologically identifiable leukemia in the bone marrow. The patient underwent successful bone marrow transplantation from an HLA-identical sibling but died 70 days after the transplant from disseminated aspergillosis.

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Aleukemic Leukemia Cutis

Hansen¹,

Barnett²,

Hanson³

et al. 1986

Arch Dermatol

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Leukemic dermal infiltrates at permanent indwelling central venous catheter insertion sites

Niazi

Molt

Mittelman

et al. 1991

Cancer

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Three cases of leukemic dermal infiltrates at permanent indwelling central venous catheter insertion sites in patients with acute myelogenous leukemia are reported. Two patients had a localized soft tissue mass at the previous permanent indwelling catheter insertion site as the sole initial manifestation of relapse after achieving complete remission and undergoing bone marrow transplantation. The third patient had catheter tunnel sepsis preceding leukemic dermal infiltration. A review of the English language literature showed that this condition is rare with no specific pathogenetic mechanisms identified. Patients with unresolved catheter tunnel infections in acute leukemia and persistent chest wall masses that appear after a previous permanent indwelling catheter should have a biopsy done and be treated promptly. Cancer 68:2281–2283, 1991.

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Testicular relapse in adult acute myelogenous leukemia

Shafer

Burris

O’Rourke

1992

Cancer

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Testicular relapse (TR) in adult acute myelogenous leukemia (AML) is uncommon, occurring in only 1–2% of patients with bone marrow relapse. TR in the absence of systemic relapse has been reported previously in 2 adults and 12 children, of which 67% were monocytic variants of AML. This article presents the case of a 29‐year‐old man with AML that relapsed in his testicle without evidence of bone marrow relapse. This patient and the two previously mentioned adults experienced bone marrow relapse within 2 months and died within 7 months of their TR. TR in adult myelogenous leukemia should be considered a harbinger of systemic relapse and suggests a need for aggressive local and systemic therapy.

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The Acute Monocytic Leukemias

Cited by 53 publications

References 0 publications

Aleukemic Leukemia Cutis

Aleukemic Leukemia Cutis

Leukemic dermal infiltrates at permanent indwelling central venous catheter insertion sites

Testicular relapse in adult acute myelogenous leukemia

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