The acute phase response of plasma protein synthesis during experimental inflammation.

Schreiber, Gerhard; Howlett, Geoffrey J.; Nagashima, Mariko; Millership, Anne; Martin, H L; Urban, Jörg; Kotler, Leore

doi:10.1016/s0021-9258(18)34015-8

Cited by 179 publications

(12 citation statements)

References 32 publications

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“…During an acute phase response, the plasma concentration of positive APP increases as the liver upregulates the synthesis of alpha globulins [84,85]. Conversely, the liver reduces the synthesis of albumin, paraoxonase, retinol-binding protein, and lipoproteins (reflected by plasma concentration of retinol and cholesterol respectively).…”

Section: Inflammation and Acute Phase Proteins Biomarkersmentioning

confidence: 99%

“…Conversely, the liver reduces the synthesis of albumin, paraoxonase, retinol-binding protein, and lipoproteins (reflected by plasma concentration of retinol and cholesterol respectively). The drop of their plasma concentration is proportional to the severity of the acute phase response [84][85][86]. Total protein includes serum albumin and globulin; thus, trends of total protein and globulin could serve as reliable markers of changes in plasma protein fractions during the acute phase response.…”

Section: Inflammation and Acute Phase Proteins Biomarkersmentioning

confidence: 99%

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Changes of Plasma Analytes Reflecting Metabolic Adaptation to the Different Stages of the Lactation Cycle in Healthy Multiparous Holstein Dairy Cows Raised in High-Welfare Conditions

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Mezzetti

Ferronato

et al. 2021

Animals

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Here, we tested the changes occurring in several plasma analytes during different stages of the lactation cycle of high welfare raised multiparous Holstein cows, and provided reference intervals (RI) for plasma analytes concentrations. Eleven high-welfare farms (HWF) located in Northern Italy were selected and their herds used to recruit 361 clinically healthy cows undergoing the dry (from −30 to −10 days from real calving; DFC), the postpartum (from 3 to 7 DFC), the early lactation (from 28 to 45 DFC) and the late lactation phases (from 160 to 305 DFC). Cows affected by subclinical diseases (SCD) were retrospectively excluded, and a subset of 285 cows was selected. Data of plasma analytes underwent ANOVA testing using physiological phases as predictors. The individual effect of each phase was assessed using a pairwise t-test assuming p ≤ 0.05 as a significance limit. A bootstrap approach was used to define the reference interval (RI) for each blood analyte within physiological phases having a pairwise t-test p ≤ 0.05. The concentration of nonesterified fatty acids, albumin, cholesterol, retinol, paraoxonase and tocopherol changed throughout all the physiological phases, whereas the concentration of K, alkaline phosphatase and thiol groups remained stable. Triglycerides, Zn, and ferric ion reducing antioxidant power in the dry phase and BHB, Ca, myeloperoxidase, haptoglobin, reactive oxygen metabolites and advanced oxidation of protein product in postpartum differed compared with other physiological phases. During the dry phase, Packed cell volume, Cl, and urea concentrations were similar to during the postpartum phase. Similarly, Na, γ-glutamyl transferase and β-carotene concentrations were similar to during the early lactation phase; fructosamine and bilirubin concentrations were similar to during the late lactation phase. During the postpartum phase, fructosamine and P concentrations were similar to during the early lactation phase, and the aspartate transaminase concentration was similar to during the late lactation phase. During the early lactation phase, Mg, creatinine, total protein, globulin and ceruloplasmin concentrations were similar to during the postpartum phase, while the urea concentration was similar to during the late lactation phase. All these plasma analytes differed among the other phases. This study identifies physiological trends affecting plasma analytes concentrations during the different stages of the lactation cycle and provides a guideline for the duration and magnitude of their changes when animals are healthy and raised in optimal welfare conditions.

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Section: Inflammation and Acute Phase Proteins Biomarkersmentioning

confidence: 99%

Section: Inflammation and Acute Phase Proteins Biomarkersmentioning

confidence: 99%

Changes of Plasma Analytes Reflecting Metabolic Adaptation to the Different Stages of the Lactation Cycle in Healthy Multiparous Holstein Dairy Cows Raised in High-Welfare Conditions

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Mezzetti

Ferronato

et al. 2021

Animals

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“…Serum Protein Profiles and Serum SAA. Although the regulation of APP production is known to occur mostly at the transcription level (23,32), posttranscriptional and/or posttranslational effects have been described (33,34). To evaluate if the alterations in mRNA induction observed are reflected by equivalent changes in circulating plasma proteins, we analyzed the protein profiles of sera from LPS-and turpentinetreated mice (Fig.…”

Section: The Mrna Coding For the Class 2 App Ot2m Is Not Induced In The Il-6-/-micementioning

confidence: 99%

Defective inflammatory response in interleukin 6-deficient mice.

Fattori

Cappelletti

Costa

et al. 1994

The Journal of Experimental Medicine

497

309

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SummarySystemic and localized inflammation elicit a number of host responses which include fever, cachexia, hypoglycemia, and major changes in the concentration of liver plasma proteins. Interlenkin 6 (IL-6) is considered an important mediator of the inflammatory response, together with IL-1 and tumor necrosis factor c~ (TNF-c 0. The purpose of this study was to unequivocally determine the role of IL-6 in these phenomena making use of IL-6-deficient mice that we have recently generated by gene targeting. We report here that in the absence of IL-6, mice are unable to mount a normal inflammatory response to localized tissue damage generated by turpentine injection. The induction of acute phase proteins is dramatically reduced, mice do not lose body weight and only suffer from mild anorexia and hypoglycemia. In contrast, when systemic inflammation is elicited through the injection of bacterial lipopolysaccharide (LPS), these parameters are altered to the same extent both in wild-type and IL-6-deficient mice, demonstrating that under these conditions IL-6 function is dispensable. Moreover, we show that LPS-treated IL-6-deficient mice produce three times more TNF-c~ than wild-type controls, suggesting that increased TNF-c~ production might be one of the compensatory mechanisms through which a normal response to LPS is achieved in the absence of IL-6. We also show that corticosterone is normally induced in IL-6-deficient mice, demonstrating that IL-6 is not required for the activation of the hypothahmicpituitary-adrenal axis. Our results reinforce the idea that different patterns of cytokines are involved in systemic and localized tissue damage, and identify IL-6 as an essential mediator of the inflammatory response to localized inflammation.

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“…In this work, we also demonstrated that irradiation modulates Lipocalin-2 gene expression in both liver and lung but with different consequences in term of induction of changes at the serum level. In fact, the changes of serum level of Lipocalin-2 in liver-irradiated rats bear signs of an acute phase reaction (Schreiber et al, 1982).…”

Section: Discussionmentioning

confidence: 99%

Serum Lipocalin-2 (LCN-2) as a major acute phase protein under different pathological conditions in vivo and in vitro studies

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The acute phase response of plasma protein synthesis during experimental inflammation.

Cited by 179 publications

References 32 publications

Changes of Plasma Analytes Reflecting Metabolic Adaptation to the Different Stages of the Lactation Cycle in Healthy Multiparous Holstein Dairy Cows Raised in High-Welfare Conditions

Changes of Plasma Analytes Reflecting Metabolic Adaptation to the Different Stages of the Lactation Cycle in Healthy Multiparous Holstein Dairy Cows Raised in High-Welfare Conditions

Defective inflammatory response in interleukin 6-deficient mice.

Serum Lipocalin-2 (LCN-2) as a major acute phase protein under different pathological conditions in vivo and in vitro studies

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