The acute toxicity of nickel to Daphnia magna: Predictive capacity of bioavailability models in artificial and natural waters

Deleebeeck, Nele M.E.; Schamphelaere, Karel A.C. De; Heijerick, D.G.; Bossuyt, Beatrijs; Janssen, Colin R.

doi:10.1016/j.ecoenv.2007.05.002

Cited by 51 publications

(57 citation statements)

References 37 publications

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“…The effect of Na was not studied, because there are no known indications for Na to be involved in the mechanism of Ni uptake and/or toxicity. This is supported by the findings of Deleebeeck et al [11], who reported that Na does not affect acute Ni toxicity to D. magna.…”

Section: Introductionsupporting

confidence: 85%

“…In contrast to the studies of Chapman et al [3], Kszos et al [1], and Keithly et al [10], the present study investigated the individual effects of Ca and Mg and, to our knowledge, is the first to demonstrate that both water hardness ions offer protection against chronic Ni toxicity. This also was demonstrated for acute Ni toxicity to D. magna and for long‐term Ni toxicity to rainbow trout [11,12]. Based on the present results, a bioavailability model could be developed that is capable of accurately predicting Ni toxicity in waters with varying ratios of Ca to Mg (see further).…”

Section: Discussionsupporting

confidence: 66%

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A novel method for predicting chronic nickel bioavailability and toxicity to Daphnia magna in artificial and natural waters

Deleebeeck

Schamphelaere

Janssen

2008

Enviro Toxic and Chemistry

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108

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In the present study, the individual effects of Ca, Mg, and pH on the chronic toxicity of Ni to Daphnia magna were examined in a series of 21-d reproduction tests in synthetic test solutions. Based on the linear increase of 21-d median effective concentrations expressed as Ni2+ activity (21-d EC50Ni2+) with increasing activities of Ca2+ and Mg2+, the effects of Ca and Mg were modeled according to single-site competition with log KCaBL = 3.53 and log KMgBL = 3.57 (BL = biotic ligand). Because the increase of 21-d EC50Ni2+ with increasing H+ activity was nonlinear, the effect of pH could not be described appropriately by single-site competition between Ni2+ and H+. Instead, the effect of pH was modeled based on an empirical linear relationship between pH and 21-d EC50pNi2+* (equal to -log [21-d EC50Ni2+ corrected for the presence of Ca and Mg]) and was superimposed on the effects of Ca and Mg. For all test solutions used for model development, the developed model predicted the observed 21-d EC50 expressed as dissolved Ni concentration with an error of less than a factor of two. The importance of dissolved organic carbon in protecting D. magna against chronic Ni toxicity was demonstrated by conducting 21-d reproduction tests in a series of Ni-spiked natural waters. Because the model tended to systematically overestimate chronic Ni toxicity in these natural waters, it was further optimized to yield more accurate predictions in natural waters. Although some room still exists for improvement, the developed model is, to our knowledge, the first to present a useful tool for assessing the risk of Ni to aquatic invertebrates.

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Section: Introductionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 66%

A novel method for predicting chronic nickel bioavailability and toxicity to Daphnia magna in artificial and natural waters

Deleebeeck

Schamphelaere

Janssen

2008

Enviro Toxic and Chemistry

Self Cite

108

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“…However, one cannot neglect the fact that in this correlation there might be the influence of other metals, especially Ni and Cd. The latter have been reported as presenting low LC50 levels to D. magna (0.86-6.3 mg L −1 [24] and 0-4.0 g L −1 [25], respectively) when compared to Mn and Fe (16-19.5 and 1.3-11 mg L −1 , respectively. Also, these metals must have influenced the sediment in the Benton community.…”

Section: Resultsmentioning

confidence: 95%

Determination of metals by total reflection X-ray fluorescence and evaluation of toxicity of a river impacted by coal mining in the south of Brazil

Lattuada

Menezes

Pavei

et al. 2009

Journal of Hazardous Materials

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“…Acute and chronic tests of D. magna are among the most frequently performed studies in aquatic toxicology because these animals are relatively easy to culture, have a short lifecycle, and can be maintained at high population densities in relatively small volumes and thus are cost effective (Barata et al 2005;De Meester and Vanoverbeke 1999;Martins et al 2007b;Tsui and Wang 2007). Of relevance to the work presented here, many studies have reported the toxicity of heavy metals to D. magna including zinc (Arambasic et al 1995;Heijerick et al 2003), copper (Arambasic et al 1995;De Schamphelaere and Janssen 2004;Knops et al 2001), nickel (Deleebeeck et al 2008), and cadmium (Knops et al 2001;Smolders et al 2005). This reproductive strategy removes any sex dependent as well as genetic variation from the toxicity studies.…”

Section: Introductionmentioning

confidence: 95%

A new approach to toxicity testing in Daphnia magna: application of high throughput FT-ICR mass spectrometry metabolomics

et al. 2008

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Currently there is a surge of interest in exploiting toxicogenomics to screen the toxicity of chemicals, enabling rapid and accurate categorisation into classes of defined mode-of-action (MOA), and prioritising chemicals for further testing. Direct infusion FT-ICR mass spectrometry-based metabolomics can provide a sensitive and unbiased analysis of metabolites in only 15 mins and therefore has considerable potential for chemical screening. The water flea, Daphnia magna, is an OECD test species and is utilised internationally for toxicity testing. However, no metabolomics studies of this species have been reported.Here we optimised and evaluated the effectiveness of FT-ICR mass spectrometry metabolomics for toxicity testing in D. magna. We confirmed that high-quality mass spectra can be recorded from as few as 30 neonates (\24 h old; 224 lg dry mass) or a single adult daphnid (301 lg dry mass). An OECD 24 h acute toxicity test was conducted with neonates at copper concentrations of 0, 5, 10, 25, 50 lg l -1 . A total of 5447 unique peaks were detected reproducibly, of which 4768 were assigned at least one empirical formula and 1017 were putatively identified based upon accurate mass measurements. Significant copper-induced changes to the daphnid metabolome, consistent with the documented MOA of copper, were detected thereby validating the approach. In addition, Nacetylspermidine was putatively identified as a novel biomarker of copper toxicity. Collectively, our results highlight the excellent sensitivity, reproducibility and mass accuracy of FT-ICR mass spectrometry, and provide strong evidence for its applicability to high-throughput screening of chemical toxicity in D. magna.

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The acute toxicity of nickel to Daphnia magna: Predictive capacity of bioavailability models in artificial and natural waters

Cited by 51 publications

References 37 publications

A novel method for predicting chronic nickel bioavailability and toxicity to Daphnia magna in artificial and natural waters

A novel method for predicting chronic nickel bioavailability and toxicity to Daphnia magna in artificial and natural waters

Determination of metals by total reflection X-ray fluorescence and evaluation of toxicity of a river impacted by coal mining in the south of Brazil

A new approach to toxicity testing in Daphnia magna: application of high throughput FT-ICR mass spectrometry metabolomics

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