Self-efficacy is regarded as one of the important aspects that could help teachers to achieve their learning goals and optimal work performance. However, in daily practice, there is only limited research that explores the importance of selfefficacy in the education process, especially for science teachers in Indonesia. This research aims to explore the relationship between science teachers' type of personality, self-efficacy, and work performance Indonesia. A total of 123 science teachers were chosen using purposive technique sampling to fill in the questionnaires as a form of self-report. The result shows that the type of personalities such as Extraversion, Conscientiousness, and Openness to Experience significantly correlate to Selfefficacy. In accordance with this result, Self-efficacy also has a positive and significant correlation with the dimension of Task Performance and Contextual Performance. However, Selfefficacy has a negative correlation to the Counterproductive Work Behavior. Therefore, the higher the three personalities possess by a teacher the higher the self-efficacy and the work performance they have. This result asserts that there is a number factor that should be considered by science teachers to achieve the best work performance. The further discussion and the limitation of this research will be explained deeper in this paper.