The adhesion protein of Mycoplasma genitalium inhibits urethral epithelial cell apoptosis through CypA-CD147 activating PI3K/ Akt/NF-κB pathway

Liao, Yating; Peng, Ke; Li, Xia; Ye, Youyuan; Liu, Peng; Zeng, Yanhua

doi:10.1007/s00253-022-12146-z

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…6 F-G). Extracellular CypA can bind to the membrane receptor CD147 on monocytes, to activate ERK and NF-κB signaling pathways, and participate in the transduction of multiple signal [28] , [29] , [30] . The results of this study showed that CD147 saw a dramatic increase on both mRNA and protein levels under the stimulation of Gbp ( Fig.…”

Section: Resultsmentioning

confidence: 99%

The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT/MAPK/NF-κB pathways

Song

Sun

Ding

et al. 2024

Journal of Advanced Research

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Section: Resultsmentioning

confidence: 99%

The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT/MAPK/NF-κB pathways

Song

Sun

Ding

et al. 2024

Journal of Advanced Research

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“…37 CD147, an inducer of MMPs, recruits monocytes and neutrophils to the inflammatory site via the CypA-activated extracellular signal-regulated protein kinases (ERK) signaling pathway. 38 We did not explore the critical role of CD147 in CypA-mediated NP, which should be further analyzed. Second, the specific cell type that was responsible for secreting CypA requires in-depth research in the future.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier

Wang,

Yang

et al. 2023

Anesthesia &Amp; Analgesia

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BACKGROUND: Dysfunction of the blood-spinal cord barrier (BSCB) contributes to the occurrence and development of neuropathic pain (NP). Previous studies revealed that the activation of cyclophilin A (CypA)-metalloproteinase-9 (MMP9) signaling pathway can disrupt the integrity of the blood-brain barrier (BBB) and aggravate neuroinflammatory responses. However, the roles of CypA-MMP9 signaling pathway on BSCB in NP have not been studied. This study aimed to investigate the effect of CypA on the structure and function of the BSCB and pain behaviors in mice with NP. METHODS: We first created the mouse chronic constriction injury (CCI) model, and they were then intraperitoneally injected with the CypA inhibitor cyclosporine A (CsA) or vehicle. Pain behaviors, the structure and function of the BSCB, the involvement of the CypA-MMP9 signaling pathway, microglia activation, and expression levels of proinflammatory factors in mice were examined. RESULTS: CCI mice presented mechanical allodynia and thermal hyperalgesia, impaired permeability of the BSCB, downregulated tight junction proteins, activated CypA-MMP9 signaling pathway, microglia activation, and upregulated proinflammatory factors, which were significantly alleviated by inhibition of CypA. CONCLUSIONS: Collectively, the CypA-MMP9 signaling pathway is responsible for CCI-induced NP in mice by impairing the structure and function of the BSCB, and activating microglia and inflammatory responses.

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The effects of CypA on apoptosis: potential target for the treatment of diseases

Chen,

Zeng,

Luo

et al. 2023

Appl Microbiol Biotechnol

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The adhesion protein of Mycoplasma genitalium inhibits urethral epithelial cell apoptosis through CypA-CD147 activating PI3K/ Akt/NF-κB pathway

Cited by 5 publications

References 45 publications

The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT/MAPK/NF-κB pathways

The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT/MAPK/NF-κB pathways

Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier

The effects of CypA on apoptosis: potential target for the treatment of diseases

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