The Adipokine Visfatin is Markedly Elevated in Obese Children

Haider, Dominik G.; Holzer, Gregor; Schaller, Georg; Weghuber, Daniel; Widhalm, Kurt; Wagner, Oswald; Kapiotis, Stylianos; Wolzt, Michael

doi:10.1097/01.mpg.0000235749.50820.b3

Cited by 96 publications

(117 citation statements)

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“…Relationship between visfatin levels and BMI status Higher circulating visfatin levels in obese children and their positive correlation with BMI have been previously reported; [16][17][18] however, these series pooled children and adolescents together, thus masking the possible effect of pubertal developmental stage and sex steroid influence. Hence, the demonstration of increased visfatin levels in a cohort made up exclusively of young prepubertal obese children constitutes an original contribution of this study.…”

Section: Discussionmentioning

confidence: 99%

“…11 However, there are contrasting reports regarding the relationship between vaspin levels, body mass index (BMI) and carbohydrate metabolism impairment, 12,13 as well as regarding the influence exerted by physical training and weight reduction on its circulating levels. 14,15 To date, the studies analyzing visfatin [16][17][18] and vaspin levels 19,20 in children and adolescents are sparse and, to our knowledge, nonexistent in young prepubertal children. Moreover, the lack of pharmacological treatments for obesity in this age range poses great difficulties in the achievement of large weight reduction based exclusively upon conservative treatment.…”

Section: Introductionmentioning

confidence: 99%

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Serum visfatin and vaspin levels in prepubertal children: effect of obesity and weight loss after behavior modifications on their secretion and relationship with glucose metabolism

et al. 2011

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Objective: To investigate the impact of obesity, weight loss and oral glucose ingestion on serum visfatin and vaspin levels in prepubertal children. Subjects and methods: A total of 100 prepubertal obese Caucasian children (OB) and 42 controls (C) were studied. The OB group was studied at baseline and after moderate (n ¼ 46) and extensive (n ¼ 14) body mass index (BMI) reduction by conservative treatment, undergoing body composition studies (dual-energy X-ray absorptiometry) and oral glucose tolerance tests (OGTTs). Serum visfatin and vaspin levels were studied throughout the OGTT, as were their relationships with insulin, leptin, leptin soluble receptor (sOB-R), adiponectin (total and high molecular weight), resistin, interleukin-6 (IL-6) and tumor necrosis factor-a levels at every time point. Results: OB had higher visfatin (Po0.001), but similar vaspin than C. BMI reduction decreased visfatin levels (Po0.001), with BMI, waist circumference and the surrogate markers of body fat (leptin and sOB-R) showing significant correlations (Po0.05) with this peptide, but not with vaspin. Visfatin and vaspin decreased during the OGTT (Po0.001). Weight reduction did not alter visfatin dynamics in the OGTT, but decreased the area under the curve (AUC) for vaspin (Po0.001), with a correlation between the AUCs for vaspin and insulin after weight loss (Po0.05). Visfatin levels were positively correlated with resistin and IL-6, after controlling for BMI and HOMA (homeostatic model assessment) index at every time point in the study. Conclusion: Serum visfatin, but not vaspin, levels are influenced by body fat content in obese children, whereas both adipokines are modulated by glucose intake in a BMI-dependent manner.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum visfatin and vaspin levels in prepubertal children: effect of obesity and weight loss after behavior modifications on their secretion and relationship with glucose metabolism

et al. 2011

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“…A recent study conducted in patients with polycystic ovary syndrome, a condition with insulin resistance, also showed that visfatin levels decreased compared with the control group after metformin treatment for 3 months (22). It was reported that visfatin secretion was regulated by insulin and glucose by means of the phosphatidylinositol 3 kinase and protein kinase B pathways (23). Other study have shown that metformin has direct actions on adipocytes and skeletal tissue and inhibits plasminogen activator inhibitor-1 in adipose tissue and stimulates AMP-activated protein kinase in mice (19), which may explain what we have observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats

Gao

Wang

Pan

et al. 2014

Arq Bras Endocrinol Metab

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Objective: Visfatin is a recently discovered adipocytokine that contributes to glucose and obesityrelated conditions. Until now, its responses to the insulin-sensitizing agent metformin and to exercise are largely unknown. We aim to investigate the impact of metformin treatment and/or swimming exercise on serum visfatin and visfatin levels in subcutaneous adipose tissue (SAT), peri-renal adipose tissue (PAT) and skeletal muscle (SM) of high-fat-induced obesity rats. Materials and methods:Sprague-Dawley rats were fed a normal diet or a high-fat diet for 16 weeks to develop obesity model. The high-fat-induced obesity model rats were then randomized to metformin (MET), swimming exercise (SWI), or adjunctive therapy of metformin and swimming exercise (MAS), besides high-fat obesity control group and a normal control group, all with 10 rats per group. Zoometric and glycemic parameters, lipid profile, and serum visfatin levels were assessed at baseline and after 6 weeks of therapy. Visfatin levels in SAT, PAT and SM were determined by Western Blot. Results: Metformin and swimming exercise improved lipid profile, and increased insulin sensitivity and body weight reduction were observed. Both metformin and swimming exercise down-regulated visfatin levels in SAT and PAT, while the adjunctive therapy conferred greater benefits, but no changes of visfatin levels were observed in SM. Conclusion: Our results indicate that visfatin down-regulation in SAT and PAT may be one of the mechanisms by which metformin and swimming exercise inhibit obesity.Arq Bras Endocrinol Metab. 2014;58(1):42-7 Keywords Endocrinology; metabolic syndrome; adipocytokine RESUMO Objetivo: A visfatina é uma adipocina recentemente descoberta que contribui com as condições relacionadas à glicose e à obesidade. Até hoje, pouco se sabe da sua resposta à metformina, um agente sensibilizador de insulina, e ao exercício. Nosso objetivo foi investigar o impacto do tratamento com metformina e/ou da natação sobre a visfatina no soro e no tecido adiposo subcutâneo (TAS), tecido adiposo perirrenal (TAP) e músculo esquelético (ME) em ratos com obesidade induzida por dieta com alto teor de gordura. Materiais e métodos: Ratos Sprague-Dawley foram alimentados com uma dieta normal ou com alto teor de gordura por 16 semanas para o desenvolvimento de um modelo de obesidade. Os ratos do modelo de obesidade foram, então, randomizados para a metformina, natação ou terapia de combinação com metformina e natação, além do grupo controle de obesidade induzida por alto teor de gordura e do grupo controle normal. Cada grupo apresentava 10 ratos. Parâmetros zoométricos e glicêmicos, perfil lipídico e níveis de visfatina sérica foram avaliados no momento inicial e após seis semanas de tratamento. Os níveis de visfatina em TAS, TAP e ME foram determinados por Western Blot. Resultados: A metformina e a natação melhoraram o perfil lipídico e aumentaram a sensibilidade à insulina, com redução do peso corporal. Tanto a metformina quanto a natação levaram à regulação para baixo do...

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“…Visfatin is related to several insulin resistant conditions, such as obesity, metabolic syndrome, and dyslipidemia [9][10][11][12][13][14]. Elevated visfatin concentrations were correlated with body fat mass and visfatin levels decrease when weight loss occurs [13,15].…”

Section: Discussionmentioning

confidence: 99%

Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children

Lee

Park

et al. 2013

Endocr J

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The Adipokine Visfatin is Markedly Elevated in Obese Children

Abstract: Visfatin may be involved in the development of metabolic derangements in obese children.

Cited by 96 publications

References 8 publications

Serum visfatin and vaspin levels in prepubertal children: effect of obesity and weight loss after behavior modifications on their secretion and relationship with glucose metabolism

Serum visfatin and vaspin levels in prepubertal children: effect of obesity and weight loss after behavior modifications on their secretion and relationship with glucose metabolism

Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats

Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children

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