The administration of transcranial electric treatment for affective disturbances therapy in alcoholic patients

Krupitsky, Evgeny; Burakov, A.M.; Karan-ova, G.F.; Katsnelson, Ja.S.; Лебедев, В. П.; Grinenko, A. Ja; Borodkin, Ju.S.

doi:10.1016/0376-8716(91)90080-i

Cited by 32 publications

(16 citation statements)

References 10 publications

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“…For some time non-invasive transcranial electrostimulation treatment (TCET) has been administered to ameliorate the abstinence symptoms associated with withdrawal from addictive substances 19,20 and management of depression. 21 There are few rigorous clinical studies to determine its value in pain management, however, although the antinociceptive action of a subperception species of TCET was demonstrated in various experimental antinociceptive models 22,23 and extracellular recording techniques indicated that these transcranial stimuli modify noxious evoked responses in pain-processing regions of the brain of rats.…”

Section: Introductionmentioning

confidence: 99%

“…24,25 This subperception stimulus is suited to clinical studies involving a double-blind crossover design. Furthermore, the reported anxiolytic 19,20 mood-enhancing e ects 21 attributed to TCET could o er additional bene®ts to SCI subjects, including lowering the management drug burden. Hence, total drug usage before, during and after sham or TCET was monitored as an additional indication of the e cacy of treatment (on the assumption subjects perceiving pain relief would use less medication).…”

Section: Introductionmentioning

confidence: 99%

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The amelioration of the suffering associated with spinal cord injury with subperception transcranial electrical stimulation

et al. 2003

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Study design: Double blind, partial crossover. Objectives: To evaluate the analgesic activity of a novel cranial electrostimulus in people with spinal cord injury (SCI). Setting: Hereward College, a residential centre that provides educational facilities for students with disabilities. Methods: Subjects with SCI experiencing chronic pain were randomly assigned into two groups, one of which received sham and the other transcranial electrostimulation treatment (TCET) on two occasions daily for four successive days. After a`wash-out' period of 8 weeks all subjects returned and received the identical stimulus that the treated cohort received on the ®rst arm of the study. Results: Pain measurements applied before and after each session indicated that the pain decreased in the treated group to 51% of that reported at the commencement of treatment; reported pain intensity did not decrease signi®cantly in the sham treated subjects. The same (sham) subject group reported experiencing 59% of the pain at the end of the second arm of the study (TCET) as on the ®rst arm (sham). No signi®cant di erences were determined between the mood of all subjects estimated before and after each sham or TCET treatment session. The reported analgesic, and combined antidepressant and anxiolytic drug use in subjects receiving TCET on the second arm of the study, was 46% and 53% respectively of the average pre-study drug use. No similar decrease in the use of the drugs was noted in the same subjects after sham treatment on the ®rst arm of the study. Salivary cortisol determinations made prior to and after each sham and treatment session implicated this corticoid in the pain-relieving mode of action of the treatment, but could not be associated with any changes in mood. Subjects receiving TCET had signi®cantly higher urinary 3-methoxy-4-hydroxy-phenylglycol (MHPG) output after the TCET treatment period than sham stimulation, implicating increased central noradrenaline (NA) metabolism in the observed e ects. Conclusion: The subjects reported less pain during, and immediately after receiving this transcranial treatment, although they were using less medication than when receiving sham treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The amelioration of the suffering associated with spinal cord injury with subperception transcranial electrical stimulation

et al. 2003

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“…† Additionally, CES has been shown to enhance anesthetic effects in humans: CES increased nitrous oxide potency by approximately 37 percent [19] and reduced the required analgesic dose of fentanyl by approximately 33 percent in patients undergoing urologic surgery [20]. CES also has anxiolytic [21][22] and mood-enhancing effects [23] in humans. CES has been demonstrated to effectively decrease spinal [24], headache [25][26][27], dental [28][29], and muscle pain and spasms [30][31][32], as well as control several conditions often associated with pain (e.g., anxiety, depression, insomnia, and generalized stress) [33].…”

Section: Introductionmentioning

confidence: 99%

“…Three patients (0.6%) reported skin irritation, and one each (0.2%) reported anger, a metallic taste, a heavy feeling, and intensified tinnitus. Several studies conducted during the 1990s, with a combined total of 259 participants, reported no side effects that could reasonably be attributed to CES use [22][23][47][48].…”

Section: Introductionmentioning

confidence: 99%

Using cranial electrotherapy stimulation to treat pain associated with spinal cord injury

Tan¹,

Rintala²,

Thornby³

et al. 2006

JRRD

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Abstract-Treatments for chronic pain in persons with spinal cord injury (SCI) have been less than effective. Cranial electrotherapy stimulation (CES), a noninvasive technique that delivers a microcurrent to the brain via ear clip electrodes, has been shown to effectively treat several neurological and psychiatric disorders. The present study examined the effects of daily 1-hour active CES or sham CES treatment (randomly assigned) for 21 days on pain intensity and interference with activities in 38 males with SCI. The active CES group (n = 18) reported significantly decreased daily pain intensity compared with the sham CES group (n = 20) (mean change: active CES = -0.73, sham CES = -0.08; p = 0.03). Additionally, the active CES group reported significantly decreased pain interference (-14.6 pre-vs postintervention, p = 0.004) in contrast to the nonsignificant decrease in the sham CES group (-4.7 pre-vs postintervention, p = 0.24). These results suggest that CES can effectively treat chronic pain in persons with SCI.

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“…The effects of alcohol on the central nervous system in AAI have been investigated from several approaches, including its influence on the cell membrane (12,33,44), and more specifically, its effect on three types of neurotransmitter: opioid peptides (7,8,21,23,47), GABA (29,31), and catecholamines (11,32). Although the effects of alcohol on the cell membrane are well known, its effect on specific neurotransmitters is controversial, particularly in the case of endogenous opioids (19).…”

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confidence: 99%

Effect of acute alcohol intoxication on the opioid system in humans

Aguirre

Arbol

Rico

et al. 1995

Alcohol

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-REQUENA. Effect of acute alcohol intoxication on the opioidsystem in humans. ALCOHOL 12(6) 559-562, 1995. -We investigated the possible relation between the endogenous opioid system and acute alcoholic intoxication in 21 subjects, of whom 13 were drinkers who came to the emergency service with evident symptoms of drunkenness, and 8 were nondrinkers who consumed 1 g alcohol per kg body weight over a short period. Different patterns of changes were found in the two groups for plasma concentrations of /~-endorphin and adrenocorticotropic hormone. In drinkers, plasma levels of both substances increased, whereas in nondrinkers both concentrations decreased, the declines being especially notable 15, 30, and 45 min after ingestion. We found no differences between the two groups in plasma cortisol concentrations. The different levels of these substances may reflect differences in drinking behavior between the two groups.

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The administration of transcranial electric treatment for affective disturbances therapy in alcoholic patients

Cited by 32 publications

References 10 publications

The amelioration of the suffering associated with spinal cord injury with subperception transcranial electrical stimulation

The amelioration of the suffering associated with spinal cord injury with subperception transcranial electrical stimulation

Using cranial electrotherapy stimulation to treat pain associated with spinal cord injury

Effect of acute alcohol intoxication on the opioid system in humans

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