The administration of triiodothyronine to rats results in a lowering of the mitochondrial membrane potential in isolated hepatocytes

Gregory, Roland B.; Berry, Michael N.

doi:10.1016/0167-4889(91)90245-s

Cited by 20 publications

(4 citation statements)

References 40 publications

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“…Thyroid hormones, especially T 3 , are known to be thermogenic. They stimulate oxidative phosphorylation and ATP exportation [12,14] and mitochondria biogenesis [9]. Their decreased concentrations at high temperature [21,32] are consistent with the reduction in heat production in observed in such conditions [23,27].…”

Section: Discussionsupporting

confidence: 59%

Effects of high temperature on body temperature and hormonal adjustments in piglets

2002

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-Effects of a high (33°C) or thermoneutral (23 °C) temperature on body temperature and endocrine parameters were studied in weaned piglets. Rectal and skin temperatures were measured in four ad libitum fed animals per temperature during three weeks. After this acclimation period, 11 blood samples were withdrawn on a 24-h period. Over the acclimation period, rectal and skin temperatures were 0.6 and 2.9°C higher, respectively, at 33°C than at 23°C (P < 0.01), this change occurring from the 1st day at 23 or 33°C. A tendency of serum leptin concentrations to be lower after meals at 33°C than at 23°C was also displayed (P = 0.09). Plasmatic concentrations in Insulin-like growth factor I and thyroxine were decreased at 33°C relative to 23°C (P < 0.01 and P < 0.06, respectively), and triiodothyronine concentrations tended to be lower at 33°C than at 23°C (P = 0.1), which could account for the lower heat production and growth observed in pigs exposed to high temperatures.piglet / heat exposure / body temperature / thyroid hormones / IGF-I Résumé -Effets d'une température ambiante élevée sur la température corporelle et les ajustements hormonaux chez le porcelet sevré. Les effets d'une température ambiante élevée (33°C) ou thermoneutre (23°C) sur la température corporelle et le statut hormonal sont étudiés chez le porcelet sevré. Les températures rectale et cutanée sont mesurées sur 4 animaux par tempé-rature, nourris à volonté et acclimatés à la température expérimentale pendant trois semaines. Après cette période, les paramètres sanguins sont mesurés sur 11 échantillons prélevés sur un nycthémère. Au cours de la période d'acclimatation, les températures rectale et cutanée sont rapidement supérieures à 33°C qu'à 23°C, respectivement de 0,6 et 2,9°C (P < 0,01). Les concentrations sériques en leptine tendent à être inférieures à 33°C à l'état nourri (P = 0,09). Les taux d'Insulin-like growth factor I et thyroxine plasmatiques sont plus faibles à 33 qu'à 23°C (respectivement P < 0,01 et P < 0,06), et les concentrations en triiodothyronine tendent à être inférieures à 33°C (P = 0,1), en accord avec la production de chaleur et la croissance plus faible de ces animaux au chaud.porcelet / chaleur / température corporelle / hormones thyroïdiennes / IGF-I Reprod. Nutr. Dev. 42 (2002) 45-53 45

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Section: Discussionsupporting

confidence: 59%

Effects of high temperature on body temperature and hormonal adjustments in piglets

2002

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“…As for UCP3 mRNA, it is specific for brown fat and muscle. Nonetheless, Gregory and Berry have observed a decrease in ΔΨ m in hepatocytes from hyperthyroid rats [19]. This observation was confirmed by Harper and Brand [20].…”

Section: Introductionsupporting

confidence: 52%

Decrease in mitochondrial energy coupling by thyroid hormones: a physiological effect rather than a pathological hyperthyroidism consequence

et al. 1998

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The effect of the in vivo thyroid status on mitochondrial membrane potential (v v8 8 m ) in isolated rat hepatocytes was studies by means of a cytofluorimetric technique and the v v8 8 mspecific probe JC-1. It is shown that the v v8 8 m level decreases in the order hypothyroid s euthyroid s hyperthyroid. Polarographic measurement of the hepatocyte respiratory rates revealed an opposite trend of values: the highest respiratory rate in hepatocytes from hyperthyroid animals, the lowest in those from hypothyroid ones. This means that mitochondrial energy coupling is highest in hypothyroid hepatocytes and lowest in hyperthyroid hepatocytes. 6-Ketocholestanol added to hepatocytes failed to counterbalance the uncoupling effect of thyroid hormones on v v8 8 m and respiration rate. Under the same conditions, 6-ketocholestanol appeared to be effective in recoupling of respiration uncoupled by low concentrations of the artificial protonophore FCCP. The mechanism and possible physiological functions of the thyroid hormone-induced decrease in mitochondrial energy coupling are discussed.z 1998 Federation of European Biochemical Societies.

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“…These observations were further corroborated by increase in liver oxidizing capacity of hyperthyroid rats accompanied by decrease in phosphate and cytosolic redox potential (11), while opposite effects were reported in livers of hypothyroid rats (12). Similarly, hepatocytes isolated from T3-treated rats show higher oxygen consumption and lower IMM potential as compared with non-treated control (13)(14)(15)(16). Also, a decrease in IMM potential has been reported in TH-treated human lymphocytes or those derived from hyperthyroid patients (17).…”

Section: Mode-of-action Of Th In Modulating Metabolic Efficiencysupporting

confidence: 64%

Thyroid Hormone and Energy Expenditure

Yehuda‐Shnaidman¹,

Kalderon²,

Bar‐Tana³

2012

Thyroid Hormone

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The administration of triiodothyronine to rats results in a lowering of the mitochondrial membrane potential in isolated hepatocytes

Cited by 20 publications

References 40 publications

Effects of high temperature on body temperature and hormonal adjustments in piglets

Effects of high temperature on body temperature and hormonal adjustments in piglets

Decrease in mitochondrial energy coupling by thyroid hormones: a physiological effect rather than a pathological hyperthyroidism consequence

Thyroid Hormone and Energy Expenditure

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