The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study

Macfarlane, Tatiana V.; Macfarlane, Gary J.; Oliver, Richard; Benhamou, Simone; Bouchardy, Christine; Ahrens, Wolfgang; Pohlabeln, Hermann; Λάγιου, Παγώνα; Lagiou, Areti; Castellsagué, Xavier; Agudo, Antonio; Merletti, Franco; Richiardi, Lorenzo; Kjærheim, Kristina; Slámová, Alena; Schejbalová, Miriam; Canova, Cristina; Simonato, Lorenzo; Talamini, Renato; Barzan, Luigi; Conway, David I.; McKinney, Patricia A.; Znaor, Ariana; Lowry, R; Thomson, Peter; Healy, Claire M.; McCartan, Bernard E.; Marron, Manuela; Hashibe, Mia; Brennan, Paul

doi:10.1007/s10552-010-9641-3

Cited by 47 publications

(56 citation statements)

References 21 publications

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“…According to the GBD 2010, between 1990 and 2010, the incidence of larynx cancer increased by 20% and nasopharynx cancer increased by 44% 153. The use of tobacco and alcohol are reported as the main risk factors for upper airway cancers 206,207. Genetic susceptibility208 and infections209 have also been implicated, perhaps explaining the remarkable geographical variation of upper airway cancers, particularly nasopharyngeal carcinoma.…”

Section: Lung Cancer and Upper Airway Cancersmentioning

confidence: 99%

Respiratory risks from household air pollution in low and middle income countries

Gordon¹,

Bruce²,

Grigg³

et al. 2014

The Lancet Respiratory Medicine

777

592

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A third of the world’s population uses solid fuel derived from plant material (biomass) or coal for cooking, heating, or lighting. These fuels are smoky, often used in an open fire or simple stove with incomplete combustion, and result in a large amount of household air pollution when smoke is poorly vented. Air pollution is the biggest environmental cause of death worldwide, with household air pollution accounting for about 3·5–4 million deaths every year. Women and children living in severe poverty have the greatest exposures to household air pollution. In this Commission, we review evidence for the association between household air pollution and respiratory infections, respiratory tract cancers, and chronic lung diseases. Respiratory infections (comprising both upper and lower respiratory tract infections with viruses, bacteria, and mycobacteria) have all been associated with exposure to household air pollution. Respiratory tract cancers, including both nasopharyngeal cancer and lung cancer, are strongly associated with pollution from coal burning and further data are needed about other solid fuels. Chronic lung diseases, including chronic obstructive pulmonary disease and bronchiectasis in women, are associated with solid fuel use for cooking, and the damaging effects of exposure to household air pollution in early life on lung development are yet to be fully described. We also review appropriate ways to measure exposure to household air pollution, as well as study design issues and potential effective interventions to prevent these disease burdens. Measurement of household air pollution needs individual, rather than fixed in place, monitoring because exposure varies by age, gender, location, and household role. Women and children are particularly susceptible to the toxic effects of pollution and are exposed to the highest concentrations. Interventions should target these high-risk groups and be of sufficient quality to make the air clean. To make clean energy available to all people is the long-term goal, with an intermediate solution being to make available energy that is clean enough to have a health impact.

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Section: Lung Cancer and Upper Airway Cancersmentioning

confidence: 99%

Respiratory risks from household air pollution in low and middle income countries

Gordon¹,

Bruce²,

Grigg³

et al. 2014

The Lancet Respiratory Medicine

777

592

View full text Add to dashboard Cite

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“…All of them were case-control studies, four were population based (Winn et al, 1991;Winn et al, 2001;Divaris et al, 2010;Macfarlane et al, 2010), one was conducted in Italy , one was a mixture (Latin American and Europe; Guha et al, 2007) and one a mixture of European countries (Macfarlane et al, 2010), all the others were from United States (Blot et al, 1983;Mashberg et al, 1985;Young et al, 1986;Winn et al, 1991). Two publications presented data on women (Blot et al, 1983;, three were on oral cancer (Young et al, 1986;Divaris et al, 2010) and all the others on oral and pharyngeal cancers.…”

Section: Oral Cancer and Mouthwashmentioning

confidence: 99%

“…Two publications presented data on women (Blot et al, 1983;, three were on oral cancer (Young et al, 1986;Divaris et al, 2010) and all the others on oral and pharyngeal cancers. One study (23) included also 5% of oesophagus cancers among cases (Macfarlane et al, 2010).…”

Section: Oral Cancer and Mouthwashmentioning

confidence: 99%

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2014

Oral Diseases

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AcknowledgementsThe International Prevention Research Institute was awarded an unrestricted research grant from Johnson & Johnson, who make one type of mouthwash, to study the effects of mouthwash in general on several aspects of dental health including plaque, gingivitis and tooth decay. Two Synthesis Meetings were held and information presented on a wide range of issues surrounding use of mouthwash. The funders had no role in formulating the study design, methodology or hypotheses investigated, nor in the interpretation of the results or conclusions. The participants gave a raft of important insights. The authors of the work are themselves alone in bearing responsibility for the integrity of the work and not all participants may agree with all statements made in the Report. Confl icts of interestNo author received any honorarium in connection with this project. Causes and prevention of periodontal disease 1.5 List of Participants in Synthesis MeetingsToothbrushing and fl ossing: frontline against dental plaque 1.6 Mouthwash Chapter 2 A systematic review with meta-analysis of mouthwash use for the prevention of supra-gingival plaques and gingivitis: Objective, methods, data retrieval and trial characteristics Chapter 3A systematic review with meta-analysis of mouthwash use for the prevention of dental plaques Chapter 4A systematic review with meta-analysis of mouthwash use for the prevention of gingivitis Chapter 5A systematic review with meta-analysis of mouthwash use for the prevention of dental caries 5.1Fluoride mouthwashes 5.2Combination of topical fl uoride compared to single topical fl uoride for preventing dental caries 5.3Materials and Methods for the combination of topical fl uoride compared to single topical fl uoride for preventing dental caries 5.4Findings for the combination of topical fl uoride compared to single topical fl uoride for preventing dental caries 5.5Fluoridation of salt Chapter 6Oral malignancy 6.1 Background 6.2 Tobacco smoking 6.3Tobacco and alcohol interaction 6.4Oral cancer and mouthwash 6.5Mechanisms of carcinogenesis of alcohol relevant to oral cancer References Appendices Executive SummaryCareful quantitative assessment of data regarding use of mouthwash and risk of common oral conditions reveals that there is a clear evidence of benefi t from use in terms of reducing the risk of dental plaque, gingivitis, dental caries and that there are no major adverse effects including no evidence of an increased risk of oral cancer among users of mouthwash containing alcohol.Despite limitations in the quality of many studies conducted, there is a signifi cant reduction of both dental plaque and gingivitis associated with use of mouthwash preparations containing chlorhexidine or essential oils as an adjunct to standard care. The effect of mouthwash containing essential oils on both plaque and gingivitis is less than chlorhexidine in studies of less than 3 months duration but improves with increasing duration of use and equals or exceeds the effect of chlorhexidine when use is 6 months of ...

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“…A number of risk factors for the development of upper aerodigestive tract cancers have been identified, including positive smoking history, alcohol abuse, body mass index greater than 30 kg/ m 2 or less than 18.4 kg/m 2 , and lack of oral health practices 9 . Several risk factors have also been identified with respect to the development of oropharyngeal cancer, including smoking and alcohol consumption 10 and a diet deficient in fruits and vegetables 11 .…”

Section: Oropharyngeal Cancer-tongue and Minor Salivary Gland Tumoursmentioning

confidence: 99%

Adenocarcinoma Not Otherwise Specified on Dorsum of Tongue: Case Report and Literature Review

et al. 2012

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Primary adenocarcinoma of the oropharynx most often arises from the minor salivary glands, and primary squamous cell carcinoma is more commonly seen arising from the tongue. Few cases of adenocarcinoma not otherwise specified of the tongue have been reported in the literature, and none found on the dorsum of the tongue. Successful treatment strategies have therefore not been defined. We report a case of adenocarcinoma located on the dorsum of the posterior one third of the tongue adjacent to the circumvallate papillae in a woman presenting with globus sensation and mild dysphagia. Treatment consisted of transoral laser excision and postoperative external-beam radiotherapy, resulting in disease-free survival at her 5-year follow-up. The goals of this report are to present a case of adenocarcinoma arising from the minor salivary gland located on the dorsum of the tongue, to discuss previous reports of similar cases, and to suggest that surgery with or without radiotherapy be used as the mainstay of treatment.

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The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study

Abstract: Risk factors already identified as being important for UADT cancers in adults are also important influences on risk in younger adults. The implication of these results is that the public health message in preventing UADT cancers remains the same to young and old alike.

Cited by 47 publications

References 21 publications

Respiratory risks from household air pollution in low and middle income countries

Respiratory risks from household air pollution in low and middle income countries

Untitled

Adenocarcinoma Not Otherwise Specified on Dorsum of Tongue: Case Report and Literature Review

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