The age-dependent effects of selective serotonin reuptake inhibitors in humans and rodents: A review

Olivier, Jocelien; Tom, B.; Arentsen, Tim; Homberg, Judith R.

doi:10.1016/j.pnpbp.2010.09.013

Cited by 113 publications

(100 citation statements)

References 127 publications

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“…Collectively, these data show that SERT blockade exerts age-dependent effects on behavior (for review see Olivier et al (2010)), leading to a variety of unfavorable outcomes in rodents, which are opposite with respect to the effects produced by SSRIs during adulthood, but comparable to SERT knockout in rodents .…”

Section: Discussionmentioning

confidence: 89%

Developmental Influence of the Serotonin Transporter on the Expression of Npas4 and GABAergic Markers: Modulation by Antidepressant Treatment

Guidotti

Calabrese

Auletta

et al. 2011

Neuropsychopharmacol

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Alterations of the serotonergic system are involved in the pathophysiology of mood disorders and represent an important target for its pharmacological treatment. Genetic deletion of the serotonin transporter (SERT) in rodents leads to an anxious and depressive phenotype, and is associated with reduced neuronal plasticity as indicated by decreased brain-derived neurotrophic factor (Bdnf) expression levels. One of the transcription factors regulating Bdnf is the neuronal PAS domain protein 4 (Npas4), which regulates activitydependent genes and neuroprotection, and has a critical role in the development of GABA synapses. On the basis of these premises, we investigated the expression of Npas4 and GABAergic markers in the hippocampus and prefrontal cortex of homozygous (SERT À/À ) and heterozygous (SERT + /À ) knockout rats, and analyzed the effect of long-term duloxetine treatment on the expression of these targets. We found that Npas4 expression was reduced in both the brain structures of adult SERT + /À and SERT À/À animals. This effect was already present in adolescent SERT À/À , and could be mimicked by prenatal exposure to the antidepressant fluoxetine. Moreover, SERT À/À rats showed a strong impairment of the GABAergic system, as indicated by the reduction of several markers, including the vesicular transporter (Vgat), glutamic acid decarboxylase-67 (Gad67), the receptor subunit GABA A receptor, gamma 2 (GABA A -g2), and calciumbinding proteins that label subgroups of the GABAergic neurons. Interestingly, chronic treatment with the antidepressant duloxetine was able to restore the physiological levels of Npas4 and GABAergic markers in SERT À/À rats, although some differences in the modulation of GABAergic genes exist between hippocampus and prefrontal cortex. Our results demonstrate that SERT knockout rats, an animal model of mood disorders, have reduced Npas4 expression that correlates with decreased expression of Bdnf exon I and IV. These changes lead to an impairment of the GABAergic system that may contribute to the anxious and depressive phenotype associated with inherited SERT downregulation.

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Section: Discussionmentioning

confidence: 89%

Developmental Influence of the Serotonin Transporter on the Expression of Npas4 and GABAergic Markers: Modulation by Antidepressant Treatment

Guidotti

Calabrese

Auletta

et al. 2011

Neuropsychopharmacol

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“…26 The 13 studies included in this systematic review have highlighted important factors associated with an increased risk of CH development. Nevertheless an additional point that needs to be made is that, aside from 1 meta-analysis, 23 5 large cohort studies, 5,13,18,20,26 and 3 case-control studies, 4,14,15 the remaining evidence was drawn from 3 case series and 1 case report. Moreover, even in the large-scale cohort and case-control studies, assessment of individual risk factors for CH was based on a limited number of cases.…”

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confidence: 99%

“…Thus, the aforementioned findings should be interpreted cautiously and regarded as possible future avenues of research under epidemiological, clinical, and preclinical settings. 1,10,13,20,30 …”

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confidence: 99%

Maternal environmental risk factors for congenital hydrocephalus: a systematic review

Kalyvas

Κalamatianos

Pantazi

et al. 2016

FOC

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OBJECTIVE Congenital hydrocephalus (CH) is one of the most frequent CNS congenital malformations, representing an entity with serious pathological consequences. Although several studies have previously assessed child-related risk factors associated with CH development, there is a gap of knowledge on maternal environmental risk factors related to CH. The authors have systematically assessed extrinsic factors in the maternal environment that potentially confer an increased risk of CH development. METHODS The Cochrane Library, MEDLINE, and EMBASE were systematically searched for works published between 1966 and December 2015 to identify all relevant articles published in English. Only studies that investigated environmental risk factors concerning the mother—either during gestation or pregestationally—were included. RESULTS In total, 13 studies (5 cohorts, 3 case series, 3 case-control studies, 1 meta-analysis, and 1 case report) meeting the inclusion criteria were identified. Maternal medication or alcohol use during gestation; lifestyle modifiable maternal pathologies such as obesity, diabetes, or hypertension; lack of prenatal care; and a low socioeconomic status were identified as significant maternal environmental risk factors for CH development. Maternal infections and trauma to the mother during pregnancy have also been highlighted as potential mother-related risk factors for CH. CONCLUSIONS Congenital hydrocephalus is an important cause of serious infant health disability that can lead to health inequalities among adults. The present study identified several maternal environmental risk factors for CH, thus yielding important scientific information relevant to prevention of some CH cases. However, further research is warranted to confirm the impact of the identified factors and examine their underlying behavioral and/or biological basis, leading to the generation of suitable prevention strategies.

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“…1 Hence, findings should be interpreted cautiously and regarded as possible future avenues of research under epidemiological, clinical, and preclinical settings. 9,14,15,16 CONCLUSION First or second pregnancies of young, illiterate women from rural background are more prone to congenital hydrocephalus. Even though a genetic basis has been speculated, most of the causative factors still remain unclear for this disorder which has wide ranging health and financial implications for the affected individuals and their families.…”

Section: Discussionmentioning

confidence: 99%

Congenital Hydrocephalus- An Epidemiological Study of Maternal Characteristics in a Tertiary Care Centre

Kadian¹,

Verma²,

Kajal³

et al. 2017

jemds

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BACKGROUNDThe epidemiology of congenital hydrocephalus is very unclear. Although various risk factors like maternal age, maternal illness and child factors have been studied in the past, still there is a gap of knowledge regarding maternal risk factors associated in congenital hydrocephalus in the literature.The objective of the study is to measure risk factor proportions of mothers among the population of a tertiary care centre. MATERIALS AND METHODSA record-based, retrospective, descriptive study with secondary data analysis was done from the medical case records of women who delivered babies with congenital hydrocephalus from Jan. 2006 to Dec. 2016. Maternal epidemiological characteristics such as maternal age, parity, place of residence, educational status as well as birth characteristics were studied and analysed by using appropriate statistical methods. RESULTSA total of 123 babies were born with congenital hydrocephalus during the study period. Most mothers in the study were second gravida (56.91%), rural based (74.79%), women between 21-30 years (80.48%) of age. Around 60.16% women were educated up to 10 th grade and most (41.46%) were homemakers. All but 5 women had vaginal births. Male babies were 52.03%, and 64.78% babies weighed above 2 kg at birth. CONCLUSIONYoung women from rural areas of low literacy and bearing their second babies are more prone to deliver babies with congenital hydrocephalus.

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The age-dependent effects of selective serotonin reuptake inhibitors in humans and rodents: A review

Cited by 113 publications

References 127 publications

Developmental Influence of the Serotonin Transporter on the Expression of Npas4 and GABAergic Markers: Modulation by Antidepressant Treatment

Developmental Influence of the Serotonin Transporter on the Expression of Npas4 and GABAergic Markers: Modulation by Antidepressant Treatment

Maternal environmental risk factors for congenital hydrocephalus: a systematic review

Congenital Hydrocephalus- An Epidemiological Study of Maternal Characteristics in a Tertiary Care Centre

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