The Agricultural Health Study

Alavanja, Michael C.R.; Sandler, Dale P.; McMaster, S.B.; Zahm, Shelia Hoar; McDonnell, Cheryl J.; Lynch, Charles F.; Pennybacker, Margaret; Rothman, Nathaniel; Dosemeci, Mustafa; Bond, Andrew E.; Blair, Aaron

doi:10.2307/3432672

Cited by 141 publications

(157 citation statements)

References 2 publications

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“…The courses were held in different locations of the province covering the entire territory. After explaining the purpose of the study and obtaining prior informed consent, a self-administered questionnaire (adapted from the Agricultural Health Study 15 ) was applied. Exposure determinants, including characteris-tics that may influence exposure levels 16 , were covered.…”

Section: Study Population and Data Collectionmentioning

confidence: 99%

Pesticide exposure and health conditions of terrestrial pesticide applicators in Córdoba Province, Argentina

et al. 2015

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Agricultural workers represent a population that is highly vulnerable to the toxic effects of pesticide exposure. This cross sectional study aimed to describe the health conditions of terrestrial pesticide applicators in Córdoba Province, Argentina, their work practices and socio-demographic characteristics, by means of a standardized self-administered questionnaire (n = 880). A descriptive analysis reported a high prevalence of occasional or frequent symptoms: 47.4% had symptoms of irritation, 35.5% fatigue, 40.4% headache and 27.6% nervousness or depression. Using logistic regression models, risk and protective factors were found for symptoms of irritation, medical consultation and hospitalization. Among the occupational exposure variables, marital status, length of time in the job, low level of protection with regard to the use of personal protective equipment, combined use of different pesticides and the application of the insecticide endosulfan, were associated with a higher frequency of reported symptoms and higher consultation rates and hospitalization.

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Section: Study Population and Data Collectionmentioning

confidence: 99%

Pesticide exposure and health conditions of terrestrial pesticide applicators in Córdoba Province, Argentina

et al. 2015

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“…34 Recruitment began in December 1993 and continued through December 1997. A total of 57,311 private and commercial pesticide applicators ( 84% of eligible applicators in both states) enrolled in the study by completing an enrollment questionnaire when they sought a restricted-use pesticide license from the State Cooperative Extension Services or Department of Agriculture.…”

Section: Study Populationmentioning

confidence: 99%

Pesticide use and colorectal cancer risk in the agricultural health study

Lee

Sandler

Blair

et al. 2007

Intl Journal of Cancer

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121

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We investigated the relationship between agricultural pesticides and colorectal cancer incidence in the Agricultural Health Study. A total of 56,813 pesticide applicators with no prior history of colorectal cancer were included in this analysis. Detailed pesticide exposure and other information were obtained from self-administered questionnaires completed at the time of enrollment (1993)(1994)(1995)(1996)(1997). Cancer incidence was determined through populationbased cancer registries from enrollment through December 31, 2002. A total of 305 incident colorectal cancers (212 colon, 93 rectum) were diagnosed during the study period, 1993-2002. Although most of the 50 pesticides studied were not associated with colorectal cancer risk, chlorpyrifos use showed significant exposure response trend (p for trend 5 0.008) for rectal cancer, rising to a 2.7-fold (95% confidence interval: 1.2-6.4) increased risk in the highest exposure category. Aldicarb was associated with a significantly increased risk of colon cancer (p for trend 5 0.001), based on a small number of exposed cases, with the highest exposure category resulting in a 4.1-fold increased risk (95% confidence interval: 1.3-12.8). In contrast, dichlorophenoxyacetic acid showed a significant inverse association with colon cancer but the association was not monotonic. Our findings should be interpreted cautiously since the literature suggesting that pesticides are related to colorectal cancer is limited. Nonetheless the possibility of an association between exposure to certain pesticides and incidence of colorectal cancer among pesticide applicators deserves further evaluation. ' 2007 Wiley-Liss, Inc.

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“…The AHS is a prospective cohort study of 57,311 licensed pesticide applicators in Iowa and North Carolina and a detailed description of this cohort has been described elsewhere [19]. Briefly, applicators were recruited from December 1993 through December 1997.…”

Section: Study Populationmentioning

confidence: 99%

Dichlorvos exposure and human cancer risk: results from the Agricultural Health Study

Koutros

Mahajan

Zheng

et al. 2007

Cancer Causes Control

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Objectives-We evaluated cancer risk from DDVP (2,2-Dichloroethenyl dimethylphosphate) exposure among pesticide applicators enrolled in the Agricultural Health Study (AHS) cohort. Results-DDVP exposure was not associated with any cancer studied here. We observed no elevation in risk among lymphohematopoietic cancers, RR = 1.00 (95% CI 0.51, 1.96) and a small excess risk associated with exposure among those with a family history of prostate cancer (RR = 1.18 (95% CI 0.73, 1.82). Methods-TheConclusion-We find little evidence of an association between cumulative lifetime use of DDVP and risk of any cancer at this stage of follow up of the AHS.

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The Agricultural Health Study

Cited by 141 publications

References 2 publications

Pesticide exposure and health conditions of terrestrial pesticide applicators in Córdoba Province, Argentina

Pesticide exposure and health conditions of terrestrial pesticide applicators in Córdoba Province, Argentina

Pesticide use and colorectal cancer risk in the agricultural health study

Dichlorvos exposure and human cancer risk: results from the Agricultural Health Study

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