“…Somewhat later, fibroblasts will start to envelop the implant while giant cells, formed from macrophages, will try to phagocytose it. All these cells are carried to the implantation site by new vessels (neovascularization); therefore, neovascularization is seen on the chronic phase of inflammation and is an indicator of diffuse inflammation [24,29,32]. Although neovascularization is a major component of the inflammatory response in the foreign body reaction, it was not included in the grading system of the previous in vivo studies of polymers in the literature [23,24,29,37].…”