The Algal Meroterpene 11-Hydroxy-1′-O-Methylamentadione Ameloriates Dextran Sulfate Sodium-Induced Colitis in Mice

Zbakh, Hanaâ; Talero, Elena; Ávila, J. Gustavo; Alcaide, Antonio Montero; Reyes, Carolina de los; Zubı́a, Eva; Motilva, Virginia

doi:10.3390/md14080149

Cited by 17 publications

(9 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, the AMTs 1 and 2 were the most potent inhibitors of the production of the three pro-inflammatory cytokines, causing decreases in the range 71.20%-84.43% at 8 µg/mL; at this concentration, compound 2 also significantly inhibited COX-2 and iNOS. The inhibitory effects observed for this molecule (compound 2, also 11-hydroxy-1 -O-methylamentadione or AMT-E) on THP-1 cells are consistent with the in vivo study described in our previous report, which showed exerting intestinal anti-inflammatory activity in colitis by down-regulating TNF-α, IL-1ß, and IL-10, as well as suppressing COX-2 and iNOS expression in the mouse colon tissue [46].…”

Section: Discussionsupporting

confidence: 91%

Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents

et al. 2020

Self Cite

View full text Add to dashboard Cite

The anti-inflammatory and anticancer properties of eight meroterpenoids isolated from the brown seaweed Cystoseira usneoides have been evaluated. The algal meroterpenoids (AMTs) 1–8 were tested for their inhibitory effects on the production of the pro-inflammatory cytokines tumor necrosis factor (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β), and the expression of cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in LPS-stimulated THP-1 human macrophages. The anticancer effects were assessed by cytotoxicity assays against human lung adenocarcinoma A549 cells and normal lung fibroblastic MRC-5 cells, together with flow cytometry analysis of the effects of these AMTs on different phases of the cell cycle. The AMTs 1–8 significantly reduced the production of TNF-α, IL-6, and IL-1β, and suppressed the COX-2 and iNOS expression, in LPS-stimulated cells (p < 0.05). The AMTs 1–8 displayed higher cytotoxic activities against A549 cancer cells than against MRC-5 normal lung cells. Cell cycle analyses indicated that most of the AMTs caused the arrest of A549 cells at the G2/M and S phases. The AMTs 2 and 5 stand out by combining significant anti-inflammatory and anticancer activities, while 3 and 4 showed interesting selective anticancer effects. These findings suggest that the AMTs produced by C. usneoides may have therapeutic potential in inflammatory diseases and lung cancer.

show abstract

Section: Discussionsupporting

confidence: 91%

Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…325 Known brown algal-derived meroterpenes have been the focus of several biological studies with atomaric acid active against Leishmania amazonensis, 326 sargaquinoic and sargahydroquinoic acids possessing anti-adipogenic and proosteoblastogenic activities 327 and 11-hydroxy-1 0 -O-methylamentadione reducing the effect of dextran sulfate-induced colitis in mice. 328 Dolastane diterpenes from Canistrocarpus cervicornis inhibited HIV-1, 329 and spartane diterpenes from Stoechospermum marginatum induced apoptosis in melanoma cells. 330 The rst total synthesis of dictyoxetane 331,332 and the unnatural enantiomer (À)-erogorgiaene, 333 were reported.…”

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2018

View full text Add to dashboard Cite

Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1277 in 432 papers for 2016), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included.

show abstract

“…Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) [ 1 ] which is a non-specific chronic inflammation of the intestine including immune disorders, genetic predisposition, environmental factors, and certain lifestyle deprivations [ 2 , 3 , 4 ]. Common clinical symptoms are weight loss, abdominal pain, diarrhoea, and hematochezia.…”

Section: Introductionmentioning

confidence: 99%

Prevent Effects of Lactobacillus Fermentum HY01 on Dextran Sulfate Sodium-Induced Colitis in Mice

et al. 2017

View full text Add to dashboard Cite

The aim of this study is to assess the preventive effects of Lactobacillus fermentum HY01 (LF-HY01) to dextran sulfate sodium induced-colitis. We observed the ratio of colon weight to its length, colon pathological changes, and the concentrations of pro-inflammatory factors (IFN-γ, IL-12, TNFα, and IL-6) in serum. We also took account of the protein levels of IκBα, NF-κB p65, iNOS, and COX-2, and we measured the best effects of different doses of Lactobacillus fermentum HY01 (low dose group was 109 CFU/kg·bw, high dose group was 1010 CFU/kg·bw) on dextran sulfate sodium-induced colitis mice. The results were remarkable, suggesting that Lactobacillus fermentum HY01 had significant preventive effects in dextran sulfate sodium induced-colitis; simultaneously, the high dose group showed the best results among other groups. It can effectively alleviate the shortened colon length, reduce the ratio of colon weight to its length, reduce edema, inflammatory cells infiltration, and colon mucosa injury, and play an important role in the down-regulation of concentrations of pro-inflammatory factors (IFN-γ, IL-12, TNFα, and IL-6). Above all, Lactobacillus fermentum HY01 shows promising prevention for IκBα degradation, inhibition of NF-κB p65 phosphorylation cascades, and decreases the protein levels of iNOS and COX-2 as well.

show abstract

The Algal Meroterpene 11-Hydroxy-1′-O-Methylamentadione Ameloriates Dextran Sulfate Sodium-Induced Colitis in Mice

Cited by 17 publications

References 48 publications

Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents

Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents

Marine natural products

Prevent Effects of Lactobacillus Fermentum HY01 on Dextran Sulfate Sodium-Induced Colitis in Mice

Contact Info

Product

Resources

About