The aluminium content of breast tissue taken from women with breast cancer

House, Emily; Polwart, Anthony; Darbre, Philippa D.; Barr, Lester; Metaxas, George; Exley, Christopher

doi:10.1016/j.jtemb.2013.05.002

Cited by 21 publications

(12 citation statements)

References 46 publications

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“…These studies differed considerably regarding the amount of aluminum found in breast tissue likely because of discrepancies in measurement techniques. Regarding, the analytical approach the measured aluminum concentrations in our cohort were similar to the studies of House et al (2013) and Rodrigues-Peres et al (2013).…”

Section: Discussionsupporting

confidence: 79%

“…So far, there exist six studies that measured aluminum concentration in breast cancer patients comparing concentrations between benign and malign breast tissues (Exley et al, 2007, House et al, 2013, Millos et al, 2009, Ng et al, 1997, Pasha et al, 2008, Rodrigues-Peres et al, 2013). These studies differed considerably regarding the amount of aluminum found in breast tissue likely because of discrepancies in measurement techniques.…”

Section: Discussionmentioning

confidence: 99%

“…We combined comprehensive questionnaire data of breast cancer cases and healthy individuals on underarm hygiene habits with data of aluminum concentration in tissue samples. We applied a well-developed and accurate method for aluminum measurement (Exley et al, 2007, House et al, 2013). A standardized sampling procedure, high purity of reagents and a high measurement accuracy minimized background contamination.…”

Section: Discussionmentioning

confidence: 99%

“…A standardized sampling procedure, high purity of reagents and a high measurement accuracy minimized background contamination. It is likely that aluminum in breast tissue has a patchy distribution (Exley et al, 2007, House et al, 2013), therefore, we collected multiple tissue samples alongside the transect from upper outer to upper inner quadrant.…”

Section: Discussionmentioning

confidence: 99%

“…Dry, weighed and defatted tissue was transferred into 20 mL PFA Teflon© vessels with venting plugs and screw caps (CEM Microwave Technology, Germany). Further tissue preparation, digestion and dilution were done according to House et al, 2013. For digestion we used high quality Nitric acid 69% Trace SELECT® (Sigma-Aldrich, Germany).…”

Section: Methodsmentioning

confidence: 99%

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Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study

et al. 2017

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BackgroundPrevious studies on breast cancer (BC), underarm cosmetic products (UCP) and aluminum salts have shown conflicting results. We conducted a 1:1 age-matched case-control study to investigate the risk for BC in relation to self-reported UCP application.MethodsSelf-reported history of UCP use was compared between 209 female BC patients (cases) and 209 healthy controls. Aluminum concentration in breast tissue was measured in 100 cases and 52 controls. Multivariable conditional logistic regression analysis was performed to estimate odds ratios (ORs) with 95% confidence intervals (CIs), adjusting for established BC risk factors.FindingsUse of UCP was significantly associated with risk of BC (p = 0.036). The risk for BC increased by an OR of 3.88 (95% CI 1.03–14.66) in women who reported using UCP's several times daily starting at an age earlier than 30 years. Aluminum in breast tissue was found in both cases and controls and was significantly associated to self-reported UCP use (p = 0.009). Median (interquartile) aluminum concentrations were significantly higher (p = 0.001) in cases than in controls (5.8, 2.3–12.9 versus 3.8, 2.5–5.8 nmol/g).InterpretationFrequent use of UCPs may lead to an accumulation of aluminum in breast tissue. More than daily use of UCPs at younger ages may increase the risk of BC.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study

et al. 2017

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Aluminium in cosmetics and personal care products

Sanajou

Şahin

Baydar

2021

J of Applied Toxicology

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Usage of inorganic ingredients like aluminium salts in cosmetics and personal care products has been a concern for producers and consumers. Although aluminium is used to treat hyperhidrosis, some worries have been raised about aluminium's role in breast cancer, breast cyst and Alzheimer's disease. The human population is exposed to aluminium from vaccines, diet, and drinking water, but the frequent use of aluminium‐based cosmetics might add additional local exposure. This paper reviews literature to determine if aluminium‐based products may pose potential harm to the body. The dermal absorption of aluminium is not widely understood. It is not yet known whether aluminium can travel from the skin to brain to cause Alzheimer's disease. Aluminium may cause gene instability, alter gene expression or enhance oxidative stress, but the carcinogenicity of aluminium has not been proved yet. Until now, epidemiological researches were based on oral information, which lacks consistency, and the results are conflicting. Future studies should target real‐life‐based long‐time exposure to antiperspirants and other aluminium‐containing cosmetics and personal care products.

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Effects of aluminum trichloride on the cartilage stimulatory growth factors in rats

Zhang

Sun

et al. 2016

Biometals

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Aluminum (Al) is considered to be a potentially toxic metal and inhibits cartilage formation. Transforming growth factor β1 (TGF-β1) and bone morphogenetic protein 2 (BMP-2) are cartilage stimulatory growth factors, which play important roles in regulating the cartilage formation. To investigate the effects of aluminum trichloride (AlCl) on the regulation of cartilage formation. Eighty Wistar rats were orally exposed to 0 (control group), 0.4 g/L (low-dose group), 0.8 g/L (mid-dose group) and 1.6 g/L (high-dose group) AlCl for 120 days, respectively. The rats body weight were decreased, the cartilage histological structure were disrupted, the cartilage and serum contents of Al and the serum level of C-telopeptide of type II collagen were all increased, the serum level of type II collagen (Col II) and alkaline phosphatase (ALP), and the mRNA expressions of TGF-β1, BMP-2, ALP and Col II were all decreased in the AlCl-treated groups compared with those in control group. These results indicate that AlCl inhibits the cartilage formation through inhibition of the cartilage stimulatory growth factors expressions.

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The aluminium content of breast tissue taken from women with breast cancer

Cited by 21 publications

References 46 publications

Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study

Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study

Aluminium in cosmetics and personal care products

Effects of aluminum trichloride on the cartilage stimulatory growth factors in rats

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