The amazing complexity of insect midgut cells: types, peculiarities, and functions

Caccia, Silvia; Casartelli, Morena; Tettamanti, Gianluca

doi:10.1007/s00441-019-03076-w

Cited by 120 publications

(108 citation statements)

References 200 publications

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“…Other authors that mention the presence of specific neuropeptides in the gut, without going into details, are Štrus et al 2019;Holtof et al 2019 andCaccia et al 2019; all three dealing with the Arthropoda and, for the old placozoan lineage, which shares neuropeptides with other bilaterian clades, Smith and Mayorova (2019). Poriferans do not seem to have secretory peptides in their genomes and the ctenophores use a completely different set of peptides unrelated to those of any other metazoan phyla (Moroz et al 2014).…”

Section: The Gut Endocrine Systemmentioning

confidence: 99%

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Structure, development and evolution of the digestive system

Hartenstein

Martinez

2019

Cell Tissue Res

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Section: The Gut Endocrine Systemmentioning

confidence: 99%

“…and Mayorova (2019; Placozoa), Godefroy et al (2019; Porifera), Gavilán et al (2019; Xenacoelomorpha), Lobo-da-Cunha (2019; Mollusca), Štrus et al (2019; Crustacea) andCaccia et al (2019; Hexapoda) and for prebilaterian and bilaterian clades in more general, bySteinmetz (2019) andHartenstein and Martinez (2019), respectively.…”

mentioning

confidence: 98%

Structure, development and evolution of the digestive system

Hartenstein

Martinez

2019

Cell Tissue Res

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“…The insect digestive tract secretes many enzymes to digest proteins, lipids, and carbohydrates, which are digested extracellularly (Weidlich et al, 2013(Weidlich et al, , 2015Holtof et al, 2019). In the insect midgut, epithelial cells can produce several digestive enzymes and direct distribution of nutrients and transport of ions and water (Caccia et al, 2019).…”

Section: Peptide Hormones Produced In the Gutmentioning

confidence: 99%

Section: Peptide Hormones Produced In the Gutmentioning

confidence: 99%

“…Generally speaking, insect midgut cells include intestinal endocrine cells, intestinal epithelial cells, columnar cells with intestinal villi, and intestinal stem cells (Billingsley and Lehane, 1996;Caccia et al, 2019). Some insects can regulate intestinal pH via goblet cells (e.g., Lepidoptera) or copper cells; endocrine cells can produce peptide hormones (Huang et al, 2015;Caccia et al, 2019). In addition to the relationship between endocrine cells and hormones, columnar cells can secrete the signaling protein Hedgehog to regulate nutrient availability and developmental timing (Rodenfels et al, 2014); columnar cells also produce and secrete digestive enzymes, lysozyme, and antimicrobial peptides, and are able to absorb nutrition (Caccia et al, 2019).…”

Section: Peptide Hormones Produced In the Gutmentioning

confidence: 99%

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Peptide Hormones in the Insect Midgut

Liu

Wang

et al. 2020

Front. Physiol.

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Insects produce many peptide hormones that play important roles in regulating growth, development, immunity, homeostasis, stress, and other processes to maintain normal life. As part of the digestive system, the insect midgut is also affected by hormones secreted from the prothoracic gland, corpus allatum, and various neuronal cells; these hormones regulate the secretion and activity of insects' digestive enzymes and change their feeding behaviors. In addition, the insect midgut produces certain hormones when it recognizes various components or pathogenic bacteria in ingested foods; concurrently, the hormones regulate other tissues and organs. In addition, intestinal symbiotic bacteria can produce hormones that influence insect signaling pathways to promote host growth and development; this interaction is the result of long-term evolution. In this review, the types, functions, and mechanisms of hormones working on the insect midgut, as well as hormones produced therein, are reviewed for future reference in biological pest control.

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Effects of high temperature on the growth performance and midgut autophagy of thermotolerant and thermosensitive silkworm strains

Guo,

Ling,

Yang

et al. 2024

Arch Insect Biochem Physiol

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High temperature stress has long‐term negative effects on the growth and development of silkworm (Bombyx mori). Different silkworm varieties show the different tolerance to high temperature. The induction of autophagy is linked to increased thermotolerance in diverse ectothermic organisms. However, the function of autophagy in the thermotolerant and thermosensitive silkworm strains under high‐temperature conditions remains unclear. The thermotolerant Liangguang NO.2 and thermosensitive Jingsong × Haoyue strains were used to explore the role of autophagy in thermotolerance. Here, we first found that the larval body weight gain was increased in the thermosensitive Jingsong × Haoyue strain, but there was no difference in the thermotolerant Liangguang NO.2 strain under high temperature conditions. High temperature stress had a negative influence on the cocoon performance in both the Liangguang NO.2 and Jingsong × Haoyue strains. Additionally, the autophagy‐related gene Atg5 mRNA expression in the Liangguang NO.2 strain was upregulated by high temperature, while the expression of Atg12 mRNA was reduced in the Jingsong × Haoyue strain. Titers of 20‐Hydroxyecdysone and the ultraspiracle 1 mRNA expression in the Liangguang NO.2 strain were upregulated by high temperature, which might be associated with the induction of autophagy. These results demonstrate the potentially regulatory mechanism of autophagy in silkworms' tolerance to high temperature, providing a theoretical basis for exploring the physiological mechanism of thermotolerance in insects.

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The amazing complexity of insect midgut cells: types, peculiarities, and functions

Cited by 120 publications

References 200 publications

Structure, development and evolution of the digestive system

Structure, development and evolution of the digestive system

Peptide Hormones in the Insect Midgut

Effects of high temperature on the growth performance and midgut autophagy of thermotolerant and thermosensitive silkworm strains

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