The ameliorating effect of some immune-stimulants on bursal and tracheal lesions of broiler chickens challenged with ND virus

Abstract

Background: Nowadays, immuno-stimulants have great importance in improving the immune system and minimising the effect of infectious diseases in poultry flocks. This study was designed to demonstrate the impact of using different immunestimulants on the reduction of the harmful implications of virulent ND virus through evaluation of histopathological lesion scores on bursa and trachea of vaccinated and infected broiler chickens with Newcastle disease (ND). Results: Eighty Ross breed broiler chicks at the age of 1 day were randomly divided into four groups, each group formed of 20 birds. Group I was vaccinated against AI, ND and IBD and used as a control. Groups II, III and IV were immunised as group I and also had immuno-stimulant supplement, Imutrix® (oregano oils plus ß-glucan), Evit liquid® (Vitamin E plus selenium) and Immunair 17.5 (Propionibacterium acnes and E. coli lipopolysaccharides), respectively. All groups were experimentally infected with virulent ND virus at the age of 28 days. The morbidity rates for groups I, II, III and IV were 15%, 5%, 5% and 10% respectively. Histopathological examination of bursa revealed hyperplasia of lymphoid follicles in group I which became more evident in groups II, III and IV. Group III showed hyperplasia of tracheal epithelium with lymphocytes and heterophils infiltration in lamina propria. CD79A-positive cells were significantly higher in bursa of group III in comparison to other groups during an immunohistochemical examination. Conclusion: It was concluded that Evit liquid® (vitamin E plus selenium) supplementation might have potent immunomodulatory effect in chickens.

Dietary administered purified β-glucan of edible mushroom (Pleurotus florida) provides immunostimulation and protection in broiler experimentally challenged with virulent Newcastle disease virus

“…Many immunostimulants from different sources have been studied in poultry (Yin et al, 1997;Hosamani et al, 2004;Ma et al, 2006). β-glucan is a potent immunostimulant having branched polysaccharide and its effect was tested on fish (Pal et al, 2007a;Pal et al, 2007b;Kamilya et al, 2006), poultry (Ali et al, 2019) and other animals (Williams and Di Luzio, 1979;Li et al, 1996;Waller and Colditz, 1999;Hiss and Sauerwein, 2003). β-glucans in oregano essential oils activate the immune cells, macrophages, dendritic cells neutrophils, B cells, T cells and natural killer cells (Kim et al, 2011).…”

“…In short, supplementation of mushroom glucan with feed (preferably by 30 mg MG/kg) having feeding regime of 20 days, showed a considerable immunostimulatory effect on broiler birds. These could be considered useful in broiler birds to prevent highly infectious diseases like ND as immunostimulants have great importance in improving the immune system and minimizing the effect of infectious diseases in poultry flocks (Ali et al, 2019), thus allowing maximum performance in poultry production (Abdel-Hafez and Mohamed, 2016).…”

Визначення Оптимальної Імуностимулюючої Дози Препарату Етр Для Курчат

“…Боротьба з інфекційними захворюваннями є дуже важливою для отримання здорового поголів'я птиці, і це, як правило, досягається шляхом проведення вакцинації для зниження ризиків щодо виникнення інфекційних хвороб (Bhadouriya, 2019;Talazadeh, 2022;Bagheri, 2023). До основних негативних наслідків вакцинації є «виснаження» і передчасна деградація лімфоїдних органів і тканин, оскільки імунокомпетентна система курчат, особливо добового віку, є ще недостатньо сформованою і відповідно, вона не може повноцінно функціонувати і можуть виникати імунодефіцитні стани (Ali, 2019).…”