The ameliorative effect of probiotics on diet-induced lipid metabolism disorders: A review

Wang, Yu; Ai, Zhiyi; Xing, Xinyue; Fan, Yuling; Zhang, Yue; Nan, Bo; Li, Xia; Wang, Yuhua; Liu, Jingsheng

doi:10.1080/10408398.2022.2132377

Cited by 26 publications

(21 citation statements)

References 92 publications

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“…Interestingly, it has been reported that CDCA is the strongest agonist of FXR followed by CA, DCA, and LCA. 5 Then, LP104 induced the activation of the FXR/SHP signaling pathway by increasing hepatic CA and CDCA concentration (Figure 5E,F), although activated FXR can upregulate SHP to inhibit BA synthesis in the liver. 36 The L. johnsonii strain exhibited a similar regulative mechanism on FXR signal to improve HFD-induced lipid metabolism disorders, which was consistent with the effects of LP104.…”

Section: ■ Discussionmentioning

confidence: 95%

“…In recent years, probiotics have quickly occupied a share of the functional food market, and the global probiotic market has been valued at USD 64.02 billion in 2022 . The fast expansion of the probiotic market is mainly due to elevating consumer health awareness and is driven by the beneficial effects of probiotics in preventing and ameliorating hyperlipidemia, obesity, diabetes, gut microbiota disorder, and inflammatory response. − Lactobacillus plantarum is a lactic acid bacteria and has made outstanding contributions in the regulation of HFD-induced lipid metabolism disorder.…”

Section: Introductionmentioning

confidence: 99%

“…The primary BAs can be further metabolized by the intestinal flora to activate receptors including FXR and G protein-coupled receptor 5 (TGR5) in the intestine, liver, and other tissues to regulate host metabolism. A lot of gut microbial-derived enzymes are involved in BA modification such as deconjugation, transport, and 7α/β-dihydroxylation . The HFD-induced imbalance of the BA–gut microbiota axis accelerates the process of lipid metabolism disorder, which leads to obesity by the mediating FXR signal .…”

Section: Introductionmentioning

confidence: 99%

“…A lot of gut microbial-derived enzymes are involved in BA modification such as deconjugation, transport, and 7α/βdihydroxylation. 5 The HFD-induced imbalance of the BA−gut microbiota axis accelerates the process of lipid metabolism disorder, which leads to obesity by the mediating FXR signal. 15 A previous study reported that HFD increased the levels of ursodeoxycholic acid (UDCA), CDCA, and lithocholic acid (LCA) that were closely related to the changes in the abundance of Clostridium.…”

Section: ■ Introductionmentioning

confidence: 99%

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Prevention of High-Fat-Diet-Induced Dyslipidemia byLactobacillus plantarumLP104 through Mediating Bile Acid Enterohepatic Axis Circulation and Intestinal Flora

Wang

Xing

et al. 2023

J. Agric. Food Chem.

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This work aimed to investigate the alleviative mechanism of Lactobacillus plantarum LP104 (LP104) isolated from kimchi on high-fat-diet-induced dyslipidemia by targeting the intestinal flora and bile acid (BA) metabolism. Oral administration of LP104 over 8 weeks reduced body weight gain and body fat, as well as ameliorating serum and hepatic dyslipidemia in HFD-fed C57BL/6N mice significantly. LP104 intervention also increased the ileal tauro-α/β-muricholic acid sodium salt (T-α-MCA or T-β-MCA) and tauroursodeoxycholic acid (TUDCA) concentrations to suppress the enterohepatic farnesoid X receptor/fibroblast growth factor 15-fibroblast growth factor receptor 4 (FXR/FGF15-FGFR4) signaling pathway, which stimulated the hepatic cholic acid (CA) and chenodeoxycholic acid (CDCA) de novo synthesis through using cholesterol. Then, LP104 treatment accelerated BA excretion with the feces and cholesterol efflux to improve HFD-caused hyperlipidemia effectively. The 16S rRNA gene high-throughput sequencing revealed that LP104 promoted intestinal flora rebalance by increasing the abundances of Bacteroides, Akkermansia, Lactobacillus, and Clostridium and decreasing the abundance of Oscillospira and Coprococcus. Meanwhile, Spearman correlation analysis demonstrated that the differential flora were closely related to BA signaling molecules including CA, CDCA, T-α-MCA, T-β-MCA, and TUDCA after LP104 intervention. These findings provided new evidence that LP104 had the potential to be used as a naturally functional food for the prevention of dyslipidemia.

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Section: ■ Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevention of High-Fat-Diet-Induced Dyslipidemia byLactobacillus plantarumLP104 through Mediating Bile Acid Enterohepatic Axis Circulation and Intestinal Flora

Wang

Xing

et al. 2023

J. Agric. Food Chem.

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“…Some studies have indicated that probiotics are conducive to the regulation of the gut microbiota and amelioration of disease ( 29 – 31 ). For individuals with dysbiosis or disruption of the gut microbiota, ingestion of probiotics may modulate the microbiota and reduce gastrointestinal symptoms ( 32 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

Changes in the gut microbiota composition of healthy young volunteers after administration of Lacticaseibacillus rhamnosus LRa05: A placebo-controlled study

Gai¹,

Dong²,

Xu³

et al. 2023

Front. Nutr.

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The gut microbiota promotes gastrointestinal health in humans; however, the effect of probiotics on the gut microbiota of healthy adults has not been documented clearly. This placebo-controlled study was conducted to assess the effect of Lacticaseibacillus rhamnosus LRa05 supplementation on the gut microbiota of healthy adults. The subjects (N = 100) were randomized 1:1 to receive (1) maltodextrin (placebo, CTL group) and (2) maltodextrin + strain LRa05 (1 × 1010 colony-forming units/day, LRa05 group). The duration of the intervention was 4 weeks, and changes in the gut microbiota from before to after the intervention were investigated using 16S rRNA high-throughput sequencing. In terms of alpha diversity, no significant difference in the composition of the gut microbiota was found between the LRa05 and CTL groups. 16S rRNA sequencing analysis showed that the relative abundance of Lacticaseibacillus significantly increased after supplementation with LRa05. Furthermore, a decreasing trend in the abundance of Sellimonas and a significant decrease in the salmonella infection pathway were observed in the LRa05 group compared with the CTL group. These findings indicate the potential of LRa05 to colonize the human gut and reduce the abundance of harmful bacteria in the microbiota.

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Mechanism of Action and Beneficial Effects of Probiotics in Amateur and Professional Athletes

Nami,

Barghi,

Shahgolzari

et al. 2024

Food Science & Nutrition

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Probiotics are live microorganisms that, when administered in adequate amounts, provide health benefits to the host. According to the International Society of Sports Nutrition (ISSN), probiotic supplementation can optimize the health, performance, and recovery of athletes at all stages of their careers. Recent research suggests that probiotics can improve immune system functions, reduce gastrointestinal distress, and increase gut permeability in athletes. Additionally, probiotics may provide athletes with secondary health benefits that could positively affect athletic performance through enhanced recovery from fatigue, improved immune function, and maintenance of healthy gastrointestinal tract function. The integration of some probiotic strains into athletes' diets and the consumption of multi‐strain compounds may lead to an improvement in performance and can positively affect performance‐related aspects such as fatigue, muscle pain, body composition, and cardiorespiratory fitness. In summary, probiotics can be beneficial for athletes at all stages of their careers, from amateur to professional. This paper reviews the progress of research on the role of probiotic supplementation in improving energy metabolism and immune system functions, reducing gastrointestinal distress, and enhancing recovery from fatigue in athletes at different levels.

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The ameliorative effect of probiotics on diet-induced lipid metabolism disorders: A review

Cited by 26 publications

References 92 publications

Prevention of High-Fat-Diet-Induced Dyslipidemia byLactobacillus plantarumLP104 through Mediating Bile Acid Enterohepatic Axis Circulation and Intestinal Flora

Prevention of High-Fat-Diet-Induced Dyslipidemia byLactobacillus plantarumLP104 through Mediating Bile Acid Enterohepatic Axis Circulation and Intestinal Flora

Changes in the gut microbiota composition of healthy young volunteers after administration of Lacticaseibacillus rhamnosus LRa05: A placebo-controlled study

Mechanism of Action and Beneficial Effects of Probiotics in Amateur and Professional Athletes

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