The Ameliorative Effects of Pycnogenol&lt;sup&gt;®&lt;/sup&gt; on Liver Ischemia-Reperfusion Injury in Rats

Tokaç, Mehmet; Bacanlı, Merve; Dumlu, Ersin Gürkan; Aydın, Sevtap; Engin, Merve; Bozkurt, Birkan; Yalçın, Abdussamed; Erel, Özcan; Kılıç, Mehmet; Başaran, Nurşen

doi:10.4274/tjps.49369

Cited by 8 publications

(11 citation statements)

References 48 publications

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“…Moreover, pine bark extract administration against cisplatin‐induced hepatotoxicity in rats was observed to significantly decrease AST concentration in a dose‐dependent manner, while ALT levels showed no significant difference (Ko et al, 2014). Treatment with 100 mg/kg of PYC has also been shown to reduce the levels of lactate dehydrogenase (LDH), AST, and ALT in ischemia/reperfusion‐induced rats (Tokaç et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

“…Oxidative stress is mainly associated with the pathogenesis of hepatic damage. Previous studies have indicated that PYC could improve the levels of antioxidant network properties such as MDA, GSH, SOD, GST, myeloperoxidase (MPO), advanced oxidation protein products, total antioxidant status, and total oxidant status, which could be impaired due to stimulators such as cisplatin‐induced hepatotoxicity (Ko et al, 2014) or ischemia/reperfusion oxidative damage (Tokaç et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

“…F2‐isoprostanes are sensitive markers of in‐vivo oxidative stress, which decrease prior to PYC administration and suggest the potent biological and antioxidant effects of pine bark extract (Ryan et al, 2008). Moreover, PYC could prevent DNA damage in hepatocytes, which is stimulated by sepsis (Taner et al, 2014) or ischemia/reperfusion oxidative damage (Tokaç et al, 2017). In addition, PYC have antioxidative and antiinflammatory effects by increasing the expression of the Nrf2 (Nuclear factor (NF)‐E2‐related factor‐2 (Nrf2)) gene which is a key transcription factor in experimental model studies (Jafari, Goudarzvand, Hajikhani, Qorbani, & Solati, 2022; Meng et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

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The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects

Nattagh‐Eshtivani

Gheflati

Barghchi

et al. 2022

Phytotherapy Research

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The prevalence of chronic diseases has increased significantly with the rising trend of sedentary lifestyles, reduced physical activity, and dietary modifications in recent decades. Inflammation and oxidative stress play a key role in the pathophysiology of several chronic diseases, such as type II diabetes, cardiovascular diseases, and hepatic conditions. Therefore, reducing inflammation and oxidative stress may be beneficial in the prevention and treatment of various chronic disorders. Since chronic diseases are not completely curable, various methods have been proposed for their control. Complementary therapies and the use of natural antioxidant and antiinflammatory compounds are among these novel approaches. Pycnogenol (PYC) is a natural compound that could control inflammation and oxidative stress. Furthermore, some previous studies have shown that PYC could effectively reduce inflammation through signaling the downstream of insulin receptors, inhibiting the phosphorylation of the serine residues of insulin receptor substrate‐1, reducing pro‐inflammatory cytokines and oxidative stress indices through the stimulation of antioxidant pathways, increasing free radical scavenging activities, preventing lipid peroxidation, and protecting the erythrocytes in glucose‐6‐phosphate dehydrogenase‐deficient individuals, although these effects have not been fully proved. The present study aimed to comprehensively review the evidence concerning the positive physiological and pharmacological properties of PYC, with an emphasis on the therapeutic potential of this natural component for enhancing human health.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects

Nattagh‐Eshtivani

Gheflati

Barghchi

et al. 2022

Phytotherapy Research

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“…The molecular basis of pycnogenol activity depends on the scavenging of reactive oxygen and reactive nitrogen species and it participates in the cellular antioxidant system [ 57 , 58 ]. Pycnogenol has cardioprotective effects by increasing blood flow through a mechanism associated with increased nitric oxide levels; it also aids in improving blood glucose control, thereby exhibiting anti-diabetic properties [ 59 , 60 ]. Pycnogenol can arrest hydroxyl, superoxide, and free oxygen radicals and reduce lipid peroxidation in red blood cells [ 61 ].…”

Section: Clinically Available Natural Productsmentioning

confidence: 99%

Natural Phytochemicals Derived from Gymnosperms in the Prevention and Treatment of Cancers

Ghaffari

Hong

Asnaashari

et al. 2021

IJMS

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The incidence of various types of cancer is increasing globally. To reduce the critical side effects of cancer chemotherapy, naturally derived compounds have been considered for cancer treatment. Gymnosperms are a group of plants found worldwide that have traditionally been used for therapeutic applications. Paclitaxel is a commercially available anticancer drug derived from gymnosperms. Other natural compounds with anticancer activities, such as pinostrobin and pinocembrin, are extracted from pine heartwood, and pycnogenol and enzogenol from pine bark. Gymnosperms have great potential for further study for the discovery of new anticancer compounds. This review aims to provide a rational understanding and the latest developments in potential anticancer compounds derived from gymnosperms.

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“…Torsiyonun neden olduğu iskemi; hipoksik hasara, dokuda laktik asit birikimine, hipoksantin ve lipid peroksidasyon seviyelerinin artışına neden olur 1 . İskemiden sonra, reperfüzyon devam ettiğinde, 'reperfüzyon hasarı' adı verilen yeni bir fizyopatolojik süreç ortaya çıkar ve bu da daha şiddetli doku hasarı gerçekleşir 3…”

Section: Introductionunclassified

Deneysel İskemi / Reperfüzyon Modeli Uygulanmış Dişi Sıçanlarda Tuba Uterina Dokusuna Pycnogenol ’un Etkisinin Değerlendirilmesi

Sunar

YAZICI

2022

Dicle Tıp Dergisi

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Adneksiyal torsiyon; en önemli jinekolojik acil durumlardan biri olarak tanımlanmaktadır. Adneksiyal torsiyondan etkilenen organlarda biri de tuba uterinadır. Ovaryum ve tuba uterinayı içeren adneksiyal torsiyon, bu yapıların infundibulopelvik ve tubaovaryum ligamentinin oluşturduğu bir merkez hat etrafında bükülerek dönmesi olarak tarif edilmektedir. Bu çalışmada, dişi sıçanlarda deneysel adneksiyal torsiyon ile oluşturulan iskemi /reperfüzyon (IR) tuba uterina hasarına karşı bir antioksidan olan pycnogenol 'un (PYC) olası koruyucu etkisini histolojik ve biyokimyasal yöntemlerle incelemeyi amaçladık.Yöntemler: 18 adet Wistar albino cinsi dişi sıçan randomize olarak 3 gruba ayrıldı. 1. Grup Sağlıklı kontrol (K), 2. Grup I/R Grubu (IR), 3. Grup I/R + Pycnogenol Grubu (PIR) olarak belirlendi. Sağ adneksa iskemi durumu vasküler klipslerle oluşturuldu. İki saat boyunca iskemi uygulandıktan sonra adneksa 2 saat boyunca reperfüze edildi. Daha sonra sıçanlar yüksek doz anestezi altında sakrifiye edilerek; tuba uterina dokularında malondialdehit (MDA) ve toplam glutatyon (tGSH) seviyeleri ile biyokimyasal olarak incelendi. Aynı zamanda dokular, rutin histolojik tespit ve takip yöntemlerinden geçirilerek histopatolojik olarak değerlendirildi.Bulgular: Çalışmada MDA seviyeleri değerlendirildiğinde; K grubu ile karşılaştırıldığında IR grubunda istatistiksel anlamlı artış, K ve PIR grubu MDA seviyelerinde ise benzerlik tespit edildi. tGSH seviyelerinde yine K grubu ile karşılaştırıldığında IR grubunda anlamlı düşüş, IR ve PIR grupları arasında ise benzerlik gözlemlendi. Histopatolojik değerlendirmelerde ise, IR uygulamasının tuba uterina dokusunda belirgin epitelyal dejenerasyon, hemoraji, ödem, PMNL infiltrasyonu ve kan damarlarında kongesyon /dilatasyona neden olduğu gözlemlendi. PIR grubunda ise bahsedilen histopatolojik değişimlerin oldukça azaldığı dikkati çekti. Özellikle PMNL infiltrasyonu ve hemorajinin, IR grubunda oldukça yoğun olduğu ve bu değişimlerin PIR grubunda istatistiksel anlamlı olarak azaldığı tespit edildi.Sonuç: Çalışmamızın biyokimyasal ve histopatolojik değerlendirmeler yaparak bu değerlendirmelerimizi istatistiksel analizler ile de destekledik. Sonuç olarak, dişi sıçanlarda AT ile oluşturulmuş tuba uterina IR hasarına karşı, antioksidan olarak kullanmış olduğumuz PYC 'nin histopatolojik ve biyokimyasal yönlerden koruyucu etkisi olduğu kanısına vardık.

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The Ameliorative Effects of Pycnogenol<sup>®</sup> on Liver Ischemia-Reperfusion Injury in Rats

Cited by 8 publications

References 48 publications

The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects

The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects

Natural Phytochemicals Derived from Gymnosperms in the Prevention and Treatment of Cancers

Deneysel İskemi / Reperfüzyon Modeli Uygulanmış Dişi Sıçanlarda Tuba Uterina Dokusuna Pycnogenol ’un Etkisinin Değerlendirilmesi

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