The Analgesic Activity of<i>Hedyosmum bonplandianum</i>: Flavonoid Glycosides

Cardenas, L. C.; Rodrı́guez, Jaime A.; Villaverde, M. C.; Riguera, Ricardo; Cadena, Rosalina; Otero, Jaime

doi:10.1055/s-2006-959597

Cited by 26 publications

(17 citation statements)

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“…Kaempferol 3‐ O ‐[ α ‐ l ‐rhamnopyranosyl (1→6)‐ β ‐ d ‐glucopyranoside] ( 30 ) and kaempferol 3‐ O ‐ β ‐ d ‐glucopyranoside ( 31 ) (i.p. 50 mg/kg) also showed significant analgesic activity in acetic acid‐induced writhing test . Toker et al .…”

Section: Resultsmentioning

confidence: 91%

“…Kaempferol also elucidated analgesic activities in acetic acid‐induced in mice at the dose of 100 mg/kg ( P < 0.01) and the inhibitory ratio was 51.6% . Moreover, Cardenas et al . reported the analgesic activity of some glycosides of kaempferol, and kaempferol 3‐ O ‐sophoroside ( 29 ) possesses significant analgesic activity in the tail clip, tail flick, tail immersion, and acetic acid‐induced writhing models (i.p.…”

Section: Resultsmentioning

confidence: 96%

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Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

Xiao

Wang

Gui

et al. 2016

Chemistry & Biodiversity

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Due to the chemical structural diversity and various analgesic mechanisms, an increasing number of studies indicated that some flavonoids from medicinal plants could be promising candidates for new natural analgesic drugs, which attract high interests of advanced users and academic researchers. The aim of this systematic review is to report flavonoids and its derivatives as new analgesic candidates based on the pharmacological evidences. Sixty-four papers were found concerning the potential analgesic activity of 46 flavonoids. In this case, the evidence for analgesic activity of flavonoids and total flavonoids was investigated. Meanwhile, the corresponding analgesic mechanism of flavonoids was discussed by generalizing and analyzing the current publications. Based on this review, the conclusion can be drawn that some flavonoids are promising candidates for painful conditions and deserve particular attention in further research and development.

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Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 96%

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

Xiao

Wang

Gui

et al. 2016

Chemistry & Biodiversity

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“…Nicotiflorin (kaempferol-3-␤-rutinoside), a flavonoid glucoside originally derived from the flower petals of Flos Carthami, a medicinal plant traditionally used in prevention and treatment of cardiovascular diseases and thrombosis in Chinese medicine (Siow et al, 2000), is known to have potent analgesic, anti-hypertensive and anti-anaphylactic effects. In an analgesic model of writhing syndrome in mouse, nicotiflorin was to significantly reduce the number of writhings and stretchings induced by 1% acetic acid solution at a dose of 80 and 40 mg/kg (Cardenas et al, 1993). In normotensive pentothal anaesthetized rats, intravenous administration of nicotiflorin produced a dosedependent decrease in systolic, diastolic and mean arterial blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Nicotiflorin reduces cerebral ischemic damage and upregulates endothelial nitric oxide synthase in primarily cultured rat cerebral blood vessel endothelial cells

Guo

Zhang

et al. 2006

Journal of Ethnopharmacology

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“…The isolation of other flavonoid glycosides like kaempferol-3-O-a-Lrhamnopyranosyl (1 ! 6)-b-D-glucopyranoside and kaempferol-3-O-b-D-glucopyranoside have been reported for H. bonplandianum (Cardenas et al, 1993) and from other Chloranthaceae species (Cao et al, 2008).…”

Section: Isolation and Identification Of Compounds From Female Hb Extmentioning

confidence: 95%