The analysis of acne increasing suicide risk

Abstract

Acne is associated with depression and anxiety; however, the relationship between acne and suicide is still unclear. This study is aimed to evaluate the association between acne and suicide by conducting a meta-analysis. Studies were identified by electronic searches of the PubMed and EMBASE databases from their inception through Jan 10, 2020. Two authors separately assessed the quality and extracted data from the selected studies. When the heterogeneity was significant, we used a random-effects model to calculate overall pooled risk estimates. Five studies involving a total of 2,276,798 participants were finally included in the meta-analysis; 52,075 participants had acne. Suicide was positively associated with acne in the overall analysis (odds ratio (OR) 1.50, 95% confidence interval (95% CI): 1.09–2.06, P = .004, I 2 = 74.1%). Subgroup analyses were performed for suicidal behavior groups ( P = .002, I 2 = 80.4%), suicidal ideation or thoughts groups ( P = .849, I 2 = 0.0%), International Classification of Diseases version 9 (ICD-9) groups ( P = .137, I 2 = 49.6%), non-ICD-9 groups ( P = .950, I 2 = 0.0%), American groups ( P = .311, I 2 = 2.4%), and non-American groups ( P = .943, I 2 = 0.0%). Sensitivity analyses indicated flawed results. No publication bias was detected. Acne may significantly increase suicide risk. Clinicians should actively treat acne and consider suicide screening. Further international studies with high-quality analyses are needed as more data are published. Ethical approval and patient consent are not required because this study is a literature-based study.

Cutaneous Body Image: How the Mental Health Benefits of Treating Dermatologic Disease Support Military Readiness in Service Members

“…12 In a recent meta-analysis including 2,276,798 participants across 5 separate studies, researchers found that suicide was positively associated with acne, carrying an odds ratio of 1.50 (95% CI, 1.09-2.06). 13 Rosacea-Rosacea is a common chronic inflammatory skin disease characterized by facial erythema, telangiectasia, phymatous changes, papules, pustules, and ocular irritation. The estimated worldwide prevalence is 5.5%.…”

Managing Dermatologic Effects of Gender-Affirming Therapy in Transgender Adolescents

“… 70 Adolescents and young adults with acne have increased association with suicide (either ideation, attempt, or death). 71 Concerns about perceived adverse effects, effectiveness of acne treatments, and perceived medical provider trivialization exacerbate psychological impact. 72 …”

“…70 Adolescents and young adults with acne have increased association with suicide (either ideation, attempt, or death). 71 Concerns about perceived adverse effects, effectiveness of acne treatments, and perceived medical provider trivialization exacerbate psychological impact. 72 Few studies linking acne with adverse mental health outcomes focus on transgender and gender non-conforming adolescents, despite their disproportionate mental health burden.…”

Safety Assessment of a Novel Topical Vehicle for Personalized Treatments in Acne

“…Thirty-five (35) volunteers recruited by the study site signed the informed consent document and complied with the inclusion and exclusion criteria. No volunteers withdrew or were excluded from the study.…”