Teaching materials can increase efficiency in learning environments. One type of materials with proven effectiveness is interactive e-books. Interactive e-books based on certain learning strategies are known to be more effective. This study focuses on analyzing, designing, developing, and evaluating an interactive e-book based on the predict-observe-explain method. The design-based research method is adopted in the study. Firstly, two physics education experts, four instructional technology field experts, and ten physics teachers were consulted about the developed interactive e-book. The pilot study with 20 high school students involved non-participant observations. Two physics education experts and four instructional technology field experts graded the developed e-book based on interactive e-book evaluation criteria. The second phase involved the determination of the platform where the interactive e-book would be developed as well as the software and tools to be used for creating multimedia materials. In the third phase, within the scope of the predict-observe-explain method, the kinds of multimedia materials and activities to be included in the e-book were designed with a physics education expert and an instructional technology expert. The interactive e-book was prepared in accordance with the target audience and subject, and design arrangements were made considering the recommendations given. The study can contribute to designers on key points to consider when creating the content of interactive e-books to be developed based on a learning method and designing and developing materials such as video, audio, and animation to be included in them. Furthermore, it can guide designers through principles and rules to be considered in designing the materials contained in interactive e-books.