The analysis of radiolysis impurities in 18F-FDG and methods of repurification

Zhang, Jinming; Li, Yungang; Liu, Jian; Zhang, Xiaojun; Tian, Jiahe

doi:10.1007/s10967-009-0408-9

Cited by 5 publications

(6 citation statements)

References 10 publications

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“…In contrast to the reactions of Pu(IV) with 1,1-dimethylhydrazine and tert-butylhydrazine, which are accelerated with UO 2 2+ ions, in reduction of Np(VI) with diethylhydroxylamine [55] and of Pu(IV) with diethyl- [54] and dimethylhydroxylamine [50] no effect of U(VI), present in a concentration of up to 0.5 M, on the reaction rate was noted.…”

Section: Substituted Hydrazinesmentioning

confidence: 96%

“…As seen from Table 2, the Pu(IV) reduction is complete within less than 0.1 min in the case of HOC 2 H 4 (C 2 H 5 )NOH + and (CH 3 ) 2 NHOH + and within ~1-1.5 min when using (C 2 H 5 ) 2 NHOH + and CH 3 NH 2 OH + (with NH 3 OH + , the complete reduction requires ~3000 min). It should be noted that, in industrial solutions, the rate of some reactions of Pu(IV) (in particular, with CH 3 NHOH [50] and (C 2 H 5 ) 2 NHOH [54]) can be still higher owing to the catalytic action of iron ions present in these solutions as a result of the apparatus corrosion. Zhang et al [54] emphasize that the content of these ions in the solution solution acidity.…”

Section: Substituted Hydrazinesmentioning

confidence: 99%

“…It should be noted that, in industrial solutions, the rate of some reactions of Pu(IV) (in particular, with CH 3 NHOH [50] and (C 2 H 5 ) 2 NHOH [54]) can be still higher owing to the catalytic action of iron ions present in these solutions as a result of the apparatus corrosion. Zhang et al [54] emphasize that the content of these ions in the solution solution acidity. Also, the reactions with methyl-, dimethyl-, and diethylhydroxylamines are inhibited by the reduction product, Pu(III) [46,49,50].…”

Section: Substituted Hydrazinesmentioning

confidence: 99%

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Organic reductants of Pu and Np ions in wet technology for spent nuclear fuel reprocessing

Marchenko

Alekseenko²,

Dvoeglazov

2015

Radiochemistry

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Scientific, technical, and patent information on the use of organic compounds as reductants of Pu and Np ions in wet technology for spent nuclear fuel reprocessing is summarized and correlated. Organic derivatives of hydrazine and hydroxylamine, and also oximes and urea derivatives at relatively low acidities and temperatures reduce Np(VI) to Np(V) and Pu(IV) to Pu(III). As the acidity and temperature are increased, Np(V) is slowly reduced to Np(IV). Alcohols, aldehydes, hydrocarbons, and acetic acid were identified among products of oxidation of the organic compounds in nitric acid medium. The above-named organic reductants can be used in different steps of the PUREX process: separation of Pu and Np from U in the first extraction cycle, purification of U to remove Np in the second cycle of uranium purification, and Pu stripping in the step of its final purification. Laboratory experiments performed on countercurrent extraction installations of mixersettlers and of centrifugal contactors demonstrated the possibility of reaching high separation factors of U from Pu and/or Np and high degrees of plutonium concentration to obtain Pu strips containing up to 150 g L -1 Pu.

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Section: Substituted Hydrazinesmentioning

confidence: 96%

Section: Substituted Hydrazinesmentioning

confidence: 99%

Section: Substituted Hydrazinesmentioning

confidence: 99%

See 1 more Smart Citation

Organic reductants of Pu and Np ions in wet technology for spent nuclear fuel reprocessing

Marchenko

Alekseenko²,

Dvoeglazov

2015

Radiochemistry

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“…This also reduces the amount of decayed products and probe radiolysis. 53,54 One idea to fulfill this concept of single dose on demand is to employ a ''decentralized'' model whereby probe production is transitioned to individual PET imaging centers or preclinical research facilities with the supply of radioisotopes, such as 18 F, from off-site cyclotrons (see Figure 1). This approach can be realized through the use of novel on-site microfluidic radiochemistry platforms capable of performing different radiochemical syntheses to yield desired probes in a microscale environment.…”

Section: Single Patient Dose On Demandmentioning

confidence: 99%

Microfluidics for Positron Emission Tomography Probe Development

et al. 2010

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Due to increased needs for Positron Emission Tomography (PET) scanning, high demands for a wide variety of radiolabeled compounds will have to be met by exploiting novel radiochemistry and engineering technologies to improve the production and development of PET probes. The application of microfluidic reactors to perform radiosyntheses is currently attracting a great deal of interest because of their potential to deliver many advantages over conventional labeling systems. Microfluidic-based radiochemistry can lead to the use of smaller quantities of precursors, accelerated reaction rates and easier purification processes with greater yield and higher specific activity of desired probes. Several ‘proof-of-principle’ examples, along with basics of device architecture and operation, and potential limitations of each design are discussed here. Along with the concept of radioisotope distribution from centralized cyclotron facilities to individual imaging centers and laboratories (“decentralized model”), an easy-to-use, standalone, flexible, fully-automated radiochemical microfluidic platform can open up to simpler and more cost-effective procedures for molecular imaging using PET.

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“…Radiochemical purity of [ 18 F]FDG decrease with the increase of activity concentration after storage for 4 hours at room temperature[72].…”

mentioning

confidence: 99%