The analysis of the prognostic value of the neutrophil/ lymphocyte ratio and the platelet/lymphocyte ratio among advanced endometrial cancer patients

Muzykiewicz, Konrad; Iwańska, Ewa; Janeczek, M; Glanowska, Izabela; Karolewski, Kazimierz; Blecharz, Paweł

doi:10.5603/gp.a2020.0164

Cited by 9 publications

(13 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, cancer is also associated with increased PLR values. A study from Poland reported that PLR was correlated with survival in patients with endometrium cancer [15]. High PLR levels were correlated with worse overall survival in oral squamous cell carcinoma patients [16].…”

Section: Discussionmentioning

confidence: 99%

Platelet to lymphocyte ratio in differentiation of benign and malignant thyroid nodules

Tel¹,

Kahveci²,

Bilgin³

et al. 2021

j-ebr

View full text Add to dashboard Cite

Differentiation of thyroid nodules, either as benign or malignant, is a real diagnostic challenge. Inflammation has an important role in development of the malignancy. Therefore, inflammatory markers are associated with malignant thyroid nodules. Platelet /lymphocyte ratio (PLR) is also one of the novel inflammatory indices derived from hemogram tests. We hypothesized whether PLR was associated with malignant thyroid nodules. For this purpose, we compared PLR levels of the patients with benign thyroid nodules to the PLR of the subjects with malignant nodules. Methods: The subjects who visited outpatient internal medicine clinics of our institution with a diagnosis of thyroid nodule were enrolled to the present retrospective study. According to the examination of the fine needle aspiration cytology (FNAC) specimen of the nodules, patients grouped into benign or malignant nodule groups. PLR of groups were compared. Results: Median PLR values of the benign and malignant thyroid nodule groups were 106 (48-432) % and 119 (48-365) %, respectively (p=0.001). PLR value higher than 106% has 69% sensitivity and 51% specificity in detecting malignant nodules (AUC: 0.59, p=0.001, 95% CI: 0.54-0.65). PLR was positively correlated with TSH level (r=0.10, p=0.34). Conclusion:We suggest that elevated PLR could be an additional tool to differentiate malignant thyroid nodules from benign ones in supportive of sonography, scintigraphy and cytology.

show abstract

Section: Discussionmentioning

confidence: 99%

Platelet to lymphocyte ratio in differentiation of benign and malignant thyroid nodules

Tel¹,

Kahveci²,

Bilgin³

et al. 2021

j-ebr

View full text Add to dashboard Cite

show abstract

“…Platelets and cancer cells interact in a pathological feed-forward loop in which the cancer cells activate platelets and platelets support cancer cells. Platelet counts are significantly elevated in endometrial cancer patients, and, in combination with other factors, are prognostic for presence of positive lymph nodes and worse prognosis [ 50 , 51 , 52 ]. Blood-based assays including platelet counts have also been shown to differentiate between endometrial cancer from atypical endometrial hyperplasia [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Sera Protein Signatures of Endometrial Cancer Lymph Node Metastases

Benbrook

Hocker

Moxley

et al. 2022

IJMS

View full text Add to dashboard Cite

The presence of lymph node metastases in endometrial cancer patients is a critical factor guiding treatment decisions; however, surgical and imaging methods for their detection are limited by morbidity and inaccuracy. To determine if sera can predict the presence of positive lymph nodes, sera collected from endometrial cancer patients with or without lymph node metastases, and benign gynecology surgical patients (N = 20 per group) were subjected to electron spray ionization mass spectrometry (ES-MS). Peaks that were significantly different among the groups were evaluated by leave one out cross validation (LOOCV) for their ability to differentiation between the groups. Proteins in the peaks were identified by MS/MS of five specimens in each group. Ingenuity Pathway Analysis was used to predict pathways regulated by the protein profiles. LOOCV of sera protein discriminated between each of the group comparisons and predicted positive lymph nodes. Pathways implicated in metastases included loss of PTEN activation and PI3K, AKT and PKA activation, leading to calcium signaling, oxidative phosphorylation and estrogen receptor-induced transcription, leading to platelet activation, epithelial-to-mesenchymal transition and senescence. Upstream activators implicated in these events included neurostimulation and inflammation, activation of G-Protein-Coupled Receptor Gβγ, loss of HER-2 activation and upregulation of the insulin receptor.

show abstract

“…Depending on the effective compensation mechanism, normal platelet counts may mask highly hypercoagulative and proinflammatory cancer activity [17]. High platelet levels can lead to poor prognoses in various cancers, including pancreatic cancer, gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer [18][19][20][21][22]. By responding to molecules that tumors produce to stimulate angiogenesis, platelets can cause thrombosis events that facilitate cancer progression [23].…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors in the treatment of gastric mucosal atypical hyperplasia by endoscopic submucosal dissection

Hong

Chen

2022

BMC Surg

View full text Add to dashboard Cite

Background Endoscopic submucosal dissection (ESD) is becoming increasingly popular as a treatment for precancerous lesions and early cancers of the stomach. However, there have been few studies on the factors associated with the recurrence of precancerous lesions after ESD. Methods To investigate the prognostic factors of gastric intraepithelial neoplasia, we retrospectively analyzed 115 patients who were treated with ESD between February 2018 and January 2020. Chi-square test and Fisher’s extract test were used to select factors for further investigation, and prognostic analysis was carried out with the Kaplan–Meier method and a Cox regression model. Results Platelet counts (P = 0.027) and albumin levels (P = 0.011) were both lower in patients with recurrence than in patients without recurrence of gastric mucosal atypical hyperplasia after ESD. Conclusions This study reveals that low platelet counts and albumin levels were probably unfavorable prognostic factors in mucosal atypical hyperplasia of the stomach.

show abstract

The analysis of the prognostic value of the neutrophil/ lymphocyte ratio and the platelet/lymphocyte ratio among advanced endometrial cancer patients

Cited by 9 publications

References 19 publications

Platelet to lymphocyte ratio in differentiation of benign and malignant thyroid nodules

Platelet to lymphocyte ratio in differentiation of benign and malignant thyroid nodules

Sera Protein Signatures of Endometrial Cancer Lymph Node Metastases

Prognostic factors in the treatment of gastric mucosal atypical hyperplasia by endoscopic submucosal dissection

Contact Info

Product

Resources

About