The analysis of the use of potentially inappropriate medications in elderly in the Slovak Republic

Jankyova, Stanislava; Rubintova, Dominika; Foltánová, Tatiana

doi:10.1007/s11096-019-00944-x

Cited by 9 publications

(15 citation statements)

References 50 publications

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“…Cross-sectional studies in Japan have reported that patients who were prescribed by two or more physicians or who consulted more medical institutions are more likely to have PP and PIM use [8,70], as shown in our study. Furthermore, our study demonstrated that there is also a significant association between PP and PIM use, which is supported by previous reports [8,[20][21][22][23][24][25][26][27]. The frequency of elderly PIM(+) patients in Japan varies from 22.9% to 67.3% [8,22,23,27,31,35,68,71,72] because of different study populations and settings, different definitions of PIMs, or different timings of the investigation.…”

Section: Discussionsupporting

confidence: 88%

“…Potentially inappropriate medications (PIMs), defined as medications with more harmful than beneficial effects on elderly patients [19], are closely related to PP [8,[20][21][22][23][24][25][26][27] and are a relevant public health concern for elderly patients [28,29]. In 2015, the Japan Geriatric Society (JGS) updated the "Guidelines for Medical Treatment and its Safety in the Elderly" and proposed medication lists regarding PIMs, "Screening Tool for Older Persons' Appropriate Prescriptions for Japanese" (STOPP-J), to contribute to improving prescription quality [30,31].…”

Section: Introductionmentioning

confidence: 99%

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Association of Self-Reported Medication Adherence with Potentially Inappropriate Medications in Elderly Patients: A Cross-Sectional Pilot Study

Miyazaki

Uchiyama

Nakamura

et al. 2020

IJERPH

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Background: Polypharmacy (PP) and potentially inappropriate medications (PIMs) cause problematic drug-related issues in elderly patients; however, little is known about the association between medication adherence and PP and PIMs. This study evaluated the association of self-reported medication adherence with PP and PIMs in elderly patients. Methods: A cross-sectional pilot study was conducted using data collected from electronic medical records of 142 self-administering patients aged ≥65 years, excluding emergency hospitalization cases. Self-reported medication adherence was assessed using the visual analogue scale (VAS). Results: Of the 142 patients, 91 (64.1%) had PP and 80 (56.3%) used at least one PIM. In univariate analysis, patients with a VAS score of 100% had a significantly higher number of female patients and ≥1 PIM use compared to other patients. We found no association between the VAS score and PP. In multivariable analysis, the use of PIMs was significantly associated with a VAS score of 100% (odds ratio = 2.32; 95% confidence interval = 1.16–4.72; p = 0.017). Conclusions: Use of PIMs by elderly patients is significantly associated with self-reported medication adherence. Pharmacists should pay more attention to prescribed medications of self-administering elderly patients in order to improve their prescribing quality.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Association of Self-Reported Medication Adherence with Potentially Inappropriate Medications in Elderly Patients: A Cross-Sectional Pilot Study

Miyazaki

Uchiyama

Nakamura

et al. 2020

IJERPH

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“…High consumption of proton pump inhibitors is frequently observed. 15 , 44 , 48 , 49 According to a critical review 25% to 75% of the prescriptions of roton inhibitors prescription have no indication of use. 50 These drugs are used to reduce gastric acid production and are associated with an increased risk of Clostridioides difficile infections and hip fractures.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Potentially Inappropriate Medications Using the EU (7)-PIM List, in a Sample of Portuguese Older Adults’ Residents in Nursing Homes

Plácido¹,

Aguiar²,

Piñeiro‐Lamas³

et al. 2022

RMHP

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Prescription of potentially inappropriate medication (PIM) in older adults is associated with poor clinical outcomes. The EU (7)-PIM list was created for the European market to improve pharmacotherapy in older adults. Purpose This work aims to characterize the medication profile and assess the presence of PIM, using the EU (7)-PIM list in older adults’ residents at nursing homes. Methods Retrospective data were collected from the anonymized nursing home records. After PIM identification, a descriptive analysis was performed, and a generalized linear model for dependent negative binomial-type variables was constructed to assess the risk of PIM. Results Of the 210 participants (mean age 85.10), 82.40% were polymedicated. PIM was observed in 86.4% participants (mean per patient = 2.30± 0.10). The most common PIM were proton pump inhibitors (n = 121, 57.62%), followed by anxiolytics (n = 96, 45.71%). 64.30% of all patients take 2–4 PIM and 5.80% take five or more PIM. The occurrence of PIM is influenced by the number of prescribed medicines (RR 1.14; 95% CI 1.1.-1.17) and the presence of digestive system diseases (RR 1.05; 95% CI 1.0–1.09). Conclusion The high prevalence of PIM observations highlights the necessity of the implementation of guidelines to prevent PIM.

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“…Most studies focus on older cohorts, aged 65 years or older, some studies also include middle-aged adults, while the addition of younger cohorts appears less common among general populations ( Table 2 ). Applying a ⩾5 medicine cut point, the prevalence of polypharmacy reported in the literature ranged from 7.0% up to 83.0%; 24 , 25 however, there was substantial heterogeneity across the literature in terms of study population, age group, methods for counting medicines and geographic locations ( Table 2 ). The inclusion of younger cohorts generally appears to lower the prevalence of polypharmacy across the literature; however, similar estimates were observed between an older sample of community-dwelling men (35.9%) 26 and primary care outpatients aged 20 years or older (39.2%), 27 which suggests in some cases the study context may be just as important a determinant as age ( Table 2 ).…”

Section: Polypharmacy (Overprescribing)mentioning

confidence: 99%

“…The prevalence of PIMs appears to be a widely reported statistic. Estimates range from 10.3% to 90.6%; 25 , 44 however, the tools used to measure prevalence varied across study populations ( Table 10 ). It was common for authors to acknowledge the differences between the tools by investigating more than one PIMs tool in the same study sample.…”

Section: Omitted Medicines (Underprescribing)mentioning

confidence: 99%

The patterns and implications of potentially suboptimal medicine regimens among older adults: a narrative review

Lee

Etherton‐Beer

Hosking

et al. 2022

Therapeutic Advances in Drug Safety

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In the context of an ageing population, the burden of disease and medicine use is also expected to increase. As such, medicine safety and preventing avoidable medicine-related harm are major public health concerns, requiring further research. Potentially suboptimal medicine regimens is an umbrella term that captures a range of indicators that may increase the risk of medicine-related harm, including polypharmacy, underprescribing and high-risk prescribing, such as prescribing potentially inappropriate medicines. This narrative review aims to provide a background and broad overview of the patterns and implications of potentially suboptimal medicine regimens among older adults. Original research published between 1990 and 2021 was searched for in MEDLINE, using key search terms including polypharmacy, inappropriate prescribing, potentially inappropriate medication lists, medication errors, drug interactions and drug prescriptions, along with manual checking of reference lists. The review summarizes the prevalence, risk factors and clinical outcomes of polypharmacy, underprescribing and potentially inappropriate medicines. A synthesis of the evidence regarding the longitudinal patterns of polypharmacy is also provided. With an overview of the existing literature, we highlight a number of key gaps in the literature. Directions for future research may include a longitudinal investigation into the risk factors and outcomes of extended polypharmacy, research focusing on the patterns and implications of underprescribing and studies that evaluate the applicability of tools measuring potentially inappropriate medicines to study settings. Plain Language Summary A review on potentially inappropriate medicine regimens Medicine use in older age is common. Older adults with more than one chronic condition are likely to use multiple medicines to manage their health. However, there are times when taking multiple medicines may be unsafe and the number of medicines, or the combination of medicines used, may increase the risk of poor health outcomes. The term medicine regimens is used to describe all the medicines an individual takes. There are several ways to measure when a medicine regimen may be inappropriate and, therefore, potentially harmful. Much research has been published looking into potentially inappropriate medicine regimens. To bring together the current research, this review provides a background on the different measures of potentially inappropriate medicine regimens. It also summarizes how many people may experience potentially inappropriate medicine regimens, the impact it is having on their health and who may be at greater risk. In doing so, we found a number of gaps in the existing evidence, indicating that our understanding of potentially inappropriate medicine regimens is incomplete. This review highlights gaps in knowledge that can be addressed by future research. With an improved understanding of potentially inappropriate medicine regimens, we may be able to better identify those at greater risk to prevent or minimize the impact of poorer health outcomes related to unsafe medicine use.

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The analysis of the use of potentially inappropriate medications in elderly in the Slovak Republic

Cited by 9 publications

References 50 publications

Association of Self-Reported Medication Adherence with Potentially Inappropriate Medications in Elderly Patients: A Cross-Sectional Pilot Study

Association of Self-Reported Medication Adherence with Potentially Inappropriate Medications in Elderly Patients: A Cross-Sectional Pilot Study

Assessment of Potentially Inappropriate Medications Using the EU (7)-PIM List, in a Sample of Portuguese Older Adults’ Residents in Nursing Homes

The patterns and implications of potentially suboptimal medicine regimens among older adults: a narrative review

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