The Andro Project

Broeder, Craig E.; Quindry, John C.; Brittingham, K.; Panton, L. B.; Thomson, J. A.; Appakondu, S; Breuel, Kevin F.; Byrd, Ryland P.; Douglas, Jenny; Earnest, Conrad P.; Mitchell, Cameron J.; Olson, Mark A.; Roy, Tracey A.; Yarlagadda, C

doi:10.1001/archinte.160.20.3093

Cited by 97 publications

(13 citation statements)

References 33 publications

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“…Immediately after intense exercise, high amounts of Androgens are required to deal with stress. Accordingly, the aromatization process from Testosterone to Beta-estradiol may be decreased and therefore result in a reduced urinary Betaestradiol excretion ( Broeder et al, 2000 ).…”

Section: Discussionmentioning

confidence: 99%

Urinary Steroid Profile in Ironman Triathletes

Marcos-Serrano

Olcina

Crespo

et al. 2018

Journal of Human Kinetics

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The aim of this study was to determine variations in the urinary steroid profile of triathletes following an Ironman event. A total of 10 male participants (age = 36.0 ± 1.27 years; body height = 179.29 ± 10.77 cm; body mass = 74.50 ± 1.04 kg) completed an Ironman Championship. Urine samples were collected before, immediately after, and 24 hours following the race. Gas chromatography-mass spectrometry (GC/MS) was used to detect and quantify catabolic and anabolic hormones: Androsterone, Dehydroepiandrosteone (DHEA), Androstenedione and Testosterone (T), Betaestradiol, Estrone, Progesterone, Cortisol (C), Cortisone, Tetrahydrocortisol (THE) and Tetrahydrocortisone (THF). These were measured in their glucuroconjugated and free forms. Androsterone (3297.80 ± 756.83 vs. 2154.26 ± 1375.38), DHEA (47.80 ± 19.21 vs. 32.62 ± 15.96) and Beta-estradiol (59.36 ± 11.7 vs. 41.67 ± 10.59) levels decreased after the event. The significant decrease of DHEA (47.80 ± 19.21 vs. 32.11 ± 14.03) remained at 24 hours. Cortisol (200.38 ± 56.60 vs. 257.10 ± 74.00) and THE (238.65 ± 81.55 vs. 289.62 ± 77.13) increased after exercise and remained elevated 24 hours later (200.38 ± 56.60 vs. 252.48 ± 62.09; 238.65 ± 81.55 vs. 284.20 ± 66.66). The following anabolic/catabolic ratios fell after exercise: T/C (0.85 ± 0.54 vs. 0.54 ± 0.29), T/THE (0.66 ± 0.29 vs. 0.40 ± 0.08), T/THE+THF (0.38 ± 0.17 vs. 0.24 ± 0.06), DHEA/THE (0.22 ± 0.05 vs. 0.12 ± 0.05), DHEA/THF (0.34 ± 0.02 vs. 0.21 ± 0.01) and DHEA/THE+THF (0.12 ± 0.02 vs. 0.08 ± 0.03). The steroid profile showed that athletes were fatigued after finishing the competition and a catabolic state remained 24 hours later.

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Section: Discussionmentioning

confidence: 99%

Urinary Steroid Profile in Ironman Triathletes

Marcos-Serrano

Olcina

Crespo

et al. 2018

Journal of Human Kinetics

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“…Consequent changes take place in the liver, where estrone is changed to E 3 . This implies that estrogens are also produced in males and not only in females; therefore, they influence male reproductive parameters (Broeder et al 2000). An estrogen action and specific cellular response are triggered through binding of these hormones to complementary ERs.…”

Section: Discussionmentioning

confidence: 99%

The slower the better: how sperm capacitation and acrosome reaction is modified in the presence of estrogens

Šebková

Černá²,

Děd³

et al. 2012

Reproduction

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In order for mammalian sperm to obtain a fertilizing ability, they must undergo a complex of molecular changes, called capacitation. During capacitation, steroidal compounds can exert a fast nongenomic response in sperm through their interaction with plasma membrane receptors, and activate crucial signaling pathways leading to time-dependent protein tyrosine phosphorylation (TyrP). Estrogen receptor beta was detected in epididymal mouse sperm; therefore, the effect of 17B-estradiol, estrone, estriol, and 17A-ethynylestradiol on mouse sperm capacitation in vitro was investigated. The effect was evaluated by positive TyrP in sperm heads and in the whole sperm lysates. Simultaneously, the state of the acrosome after the calcium ionophore-induced acrosome reaction was assessed. Generally, estrogens displayed a time and concentration-dependent stimulatory effect on sperm TyrP during capacitation. In contrast, the number of sperm that underwent the acrosome reaction was lower in the experimental groups. It has been demonstrated that both natural and synthetic estrogens can modify the physiological progress of mouse sperm capacitation. The potential risk in the procapacitation effect of estrogens can also be seen in the decreased ability of sperm to undergo the acrosome reaction. In conclusion, the capacitating ability of sperm can be significantly lowered by increasing the level of estrogens in the environment.

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“…While there is some data indicating that prohormones increase testosterone levels [231,232], there is virtually no evidence that these compounds affect training adaptations in younger men with normal hormone levels. In fact, most studies indicate that they do not affect testosterone and that some may actually increase estrogen levels and reduce HDL-cholesterol [220,231,233-238]. Consequently, although there may be some potential applications for older individuals to replace diminishing androgen levels, it appears that prohormones have no training value.…”

Section: Dietary Supplements and Athletesmentioning

confidence: 99%

ISSN exercise & sport nutrition review: research & recommendations

Kreider

Wilborn

Taylor

et al. 2010

Journal of the International Society of Sports Nutrition

320

166

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Sports nutrition is a constantly evolving field with hundreds of research papers published annually. For this reason, keeping up to date with the literature is often difficult. This paper is a five year update of the sports nutrition review article published as the lead paper to launch the JISSN in 2004 and presents a well-referenced overview of the current state of the science related to how to optimize training and athletic performance through nutrition. More specifically, this paper provides an overview of: 1.) The definitional category of ergogenic aids and dietary supplements; 2.) How dietary supplements are legally regulated; 3.) How to evaluate the scientific merit of nutritional supplements; 4.) General nutritional strategies to optimize performance and enhance recovery; and, 5.) An overview of our current understanding of the ergogenic value of nutrition and dietary supplementation in regards to weight gain, weight loss, and performance enhancement. Our hope is that ISSN members and individuals interested in sports nutrition find this review useful in their daily practice and consultation with their clients.

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The Andro Project

Cited by 97 publications

References 33 publications

Urinary Steroid Profile in Ironman Triathletes

Urinary Steroid Profile in Ironman Triathletes

The slower the better: how sperm capacitation and acrosome reaction is modified in the presence of estrogens

ISSN exercise & sport nutrition review: research & recommendations

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