1980
DOI: 10.1161/01.cir.62.5.1127
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The angiographic effect of ergonovine and nifedipine in coronary artery spasm.

Abstract: In a patient with variant angina, we have shown that the calcium-channel blocker nifedipine inhibits both spontaneous and ergonivine-induced coronary artery spasm. It had no effect, however, on the dose-related diffuse vasoconstriction caused by ergonovine, suggesting two distinct responses of coronary arteries to ergonovine provocation. Nifedipine did not cause epicardial coronary artery dilatation, as did nitroglycerin, supporting the rationale of using both therapies together to treat coronary artery spasm.

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Cited by 18 publications
(1 citation statement)
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“…ergonovine was frequently used by Heupler et al (18) and by other groups (6,7,10,11,13,31,34,38) to identify patients with a vasospastic component of their angina pectoris. This test is not without serious complications (7) and should not be recommended for uncritical and widespread clinical use (14).…”
mentioning
confidence: 99%
“…ergonovine was frequently used by Heupler et al (18) and by other groups (6,7,10,11,13,31,34,38) to identify patients with a vasospastic component of their angina pectoris. This test is not without serious complications (7) and should not be recommended for uncritical and widespread clinical use (14).…”
mentioning
confidence: 99%