The Angiopoietin/Tie2 Pathway in Hepatocellular Carcinoma

Vanderborght, Bart; Lefere, Sander; Vlierberghe, Hans Van; Devisscher, Lindsey

doi:10.3390/cells9112382

Cited by 28 publications

(20 citation statements)

References 83 publications

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“…HCC, a malignancy which is featured by a poor prognosis, causes an increasing global health problem because of the generally late diagnosis as well as the inadequacy available therapies ( 17 ). HCC is also reported to be inflammation-associated tumor, wherein immunosuppressive microenvironment can induce immune tolerance of HCC and evasion by different mechanisms ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

A Five-Gene-Based Prognostic Signature for Hepatocellular Carcinoma

Tian

Zhang

et al. 2021

Front. Med.

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Objective: This study intends to identify potential prognostic marker genes associated with the prognosis of patients suffering from hepatocellular carcinoma (HCC) based on TCGA and GEO analysis.Methods: TCGA-LIHC cohort was downloaded and the data related to HCC were extracted from The Cancer Genome Atlas (TCGA) database and subjected to differential analysis. HCC-related gene expression datasets were retrieved from the GEO database, followed by differential analysis. After intersection of the results of TCGA and GEO databases, gene interaction analysis was performed to obtain the core genes. To identify the genes related to the prognosis of HCC patients, we conducted univariate and multivariate Cox analyses.Results: Based on differential analysis of TCGA database, 854 genes were differentially expressed in HCC, any of which might link to the occurrence and progression of HCC. Meanwhile, joint analysis of HCC-related gene expression datasets in the GEO database screened 214 genes. Five core genes CDC20, TOP2A, RRM2, UBE2C and AOX1 were significantly associated with the prognosis of HCC patients and the risk model based on these five genes effectively predicted the prognosis of HCC patients.Conclusion: Collectively, our data suggest that CDC20, TOP2A, RRM2, UBE2C and AOX1 may be the key genes affecting the prognosis of patients with HCC. The five-gene signature could accurately predict the prognosis of HCC patients.

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Section: Discussionmentioning

confidence: 99%

A Five-Gene-Based Prognostic Signature for Hepatocellular Carcinoma

Tian

Zhang

et al. 2021

Front. Med.

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“…Evidence shows that the Ang-Tie2 signaling pathway mediates the pathological process of RA ( Kayakabe et al, 2012 ). The role of the Ang-Tie2 signaling pathway is mainly angiogenesis ( Vanderborght et al, 2020 ). In an earlier study, it is observed that constitutive expression of Ang-1 and Ang-2 in late-stage RA synovial fibroblasts ( Scott et al, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis

et al. 2021

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It is well known that RA (Rheumatoid arthritis) is an autoimmune disease characterized by multiple and symmetric arthropathy. The main pathological features of RA are synovial hyperplasia, angiogenesis, pannus formation, inflammatory cell infiltration, articular cartilage, bone destruction, and ultimately joint dysfunction, even deformity. IL-35 (Interleukin-35) is a new member of the IL-12 (Interleukin-12) family, which is an immunosuppressive and anti-inflammatory cytokine secreted mainly by Treg (T regulatory cells). There is evidence suggested that IL-35 can attenuate the progression of RA through influencing the immune and pathological process. It suggests that IL-35 played an important role in the pathogenesis of RA, and can be used as a potential target for the future treatment of RA. This review summarizes the recent advances of IL-35 in the pathological roles and the therapeutic potential roles in RA.

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“…Several hypotheses explaining this phenomenon have been proposed. High ANG-2 expression has been reported to be associated with rapid tumor growth, metastasis, and poor prognosis in HCC [ 26 , 27 ]. In addition, ANG-2 is associated with the progression of liver disease and fibrosis [ 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in Serum Growth Factors during Lenvatinib Predict the Post Progressive Survival in Patients with Unresectable Hepatocellular Carcinoma

Yang

Suda

Maehara

et al. 2022

Cancers

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Serum growth factor changes and their effect on prognosis during lenvatinib for unresectable hepatocellular carcinoma (HCC) remain underexplored. The sequential changes in serum growth factors during lenvatinib for unresectable HCC were evaluated in 58 patients using complete clinical data, and preserved serum was used to investigate changes in FGF-19, ANG-2, HGF, VEGF, and EGF. Patients with a complete response (CR), partial response (PR), and stable disease (SD) were evaluated for growth factor changes between the best response and progressive disease (PD) points, classified based on these changes, and evaluated by post progression survival (PPS). A total of 8, 24, 18, and 8 patients showed CR, PR, SD, and PD, respectively. Multivariate analysis revealed that age, relative dose intensity, and baseline ANG-2 were significantly associated with treatment response. Growth factor changes between the best response and PD points revealed that patients could be classified into four groups based on the EGF, ANG-2, and HGF changes. Although patient characteristics at baseline and PD, their response to lenvatinib, and PFS were similar among those groups, patients with an increase in all growth factors had significantly shorter PPS (median PPS was 553, 323, and 316 versus 173 days in groups 1–4 p = 0.032). We revealed that the evaluation of the changes in growth factors during lenvatinib could predict PPS.

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The Angiopoietin/Tie2 Pathway in Hepatocellular Carcinoma

Cited by 28 publications

References 83 publications

A Five-Gene-Based Prognostic Signature for Hepatocellular Carcinoma

A Five-Gene-Based Prognostic Signature for Hepatocellular Carcinoma

Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis

Changes in Serum Growth Factors during Lenvatinib Predict the Post Progressive Survival in Patients with Unresectable Hepatocellular Carcinoma

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