The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease

Ghaneialvar, Hori; Rahimi, Zohreh; Nomani, Hamid; Saidi, Mohammadreza; Bahrehmand, Fariborz; Vaisi-Raygani, Asad; Tavilani, Heidar; Pourmotabbed, Tayebeh

doi:10.1016/j.clinbiochem.2010.07.010

Cited by 47 publications

(34 citation statements)

References 35 publications

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“…Vaisi-Raygani et al (2010b) postulated that D allele exacerbates independent risk factor of CAD in patients with age b55 years more than that of the patients aged ≥55 years.…”

Section: Discussionmentioning

confidence: 98%

“…Previous data have suggested that genetic factors are more likely to affect young rather than old people (Freitas et al, 2008). However, smoking, dyslipidemia, and familiarity are more frequent in younger than in older patients (Vaisi-Raygani et al, 2010b). In addition, CAD risk factors, such as diabetes mellitus, dyslipidemia, hypertension and obesity may have both genetic and environmental contributors (Hauser et al, 2003).…”

Section: Discussionmentioning

confidence: 98%

“…ACE D allele has been correlated to increase serum level of ACE that is responsible for the conversion of angiotensin I to the peptide precursor angiotensin II which induces aldosterone production. Elevation of circulating levels of aldosterone influences on arterial hypertension, cardiac fibrosis and, consequently, both diastolic dysfunction and ventricular remodeling (Vaisi-Raygani et al, 2010b). During atherogenesis angiotensin II is responsible for adhesion and diapedesis of circulating monocytes into the intima through the stimulation of the expression of several adhesion molecules and chemoattractants.…”

Section: Discussionmentioning

confidence: 99%

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Renin–angiotensin system genes polymorphism in Egyptians with premature coronary artery disease

El-Aziz

Hussein

Mohamed

et al. 2012

Gene

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“…Vaisi-Raygani et al (2010b) postulated that D allele exacerbates independent risk factor of CAD in patients with age b55 years more than that of the patients aged ≥55 years.…”

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Renin–angiotensin system genes polymorphism in Egyptians with premature coronary artery disease

El-Aziz

Hussein

Mohamed

et al. 2012

Gene

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“…Conversely, Chen et al (2012) found the D/D genotype associated with ACS and disease severity in Taiwan population. Besides, other studies have demonstrated a consistent association of the polymorphism with myocardial infarction or coronary artery disease (Keavney et al, 2000;Kaiser Jamil, 2009;Vaisi-Raygani et al, 2010). The relationship of this polymorphism with cardiovascular disease has been correlated with its functional effect.…”

Section: Discussionmentioning

confidence: 99%

Research Article Assessment of the rs4340 ACE gene polymorphism in acute coronary syndrome in a Western Mexican population.

Valdez-Haro¹,

Valle²,

Valdés-Alvarado³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Acute coronary syndrome (ACS) is considered one of the main causes of death worldwide. Contradictory findings concerning the impact of the angiotensin-converting enzyme (ACE) gene on cardiovascular diseases have been reported. Previous conclusions point out that the variability in results depends on ethnicity and genetic polymorphisms to determine the association of rs4340 polymorphisms of the ACE gene and ACE circulating levels in ACS. Genotyping of rs4340 polymorphisms was performed in a total of 600 individuals from Western Mexico divided into two groups: the ACS and the control group (CG). The polymorphisms were identified by polymerase chain reaction. Serum ACE concentration was determined by enzyme-linked immunosorbent assay. D/D carriers had higher ACE levels than I/I carriers (3.6 vs 2.8 ng/mL, P < 0.0021) in the CG. The D/D genotype of the rs4340 polymorphism is associated with higher ACE concentration levels; however, the polymorphism was not associated with ACS.

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“…A study of genetic variants on human chromosome 22 has suggested that humans harbor a similar level of INDELs [32]. Recent evidence has indicated that angiotensin-converting enzyme (ACE) INDELs were associated with hypertension [33], diabetes mellitus [34], hypertrophic cardiomyopathy [35], and coronary heart disease [36]. However, the association between ACE INDELs and stroke has failed to be established [37,38].…”

Section: Discussionmentioning

confidence: 99%

Genetic Variants in the Promoter Region of the <i>ALOX5AP</i> Gene and Susceptibility of Ischemic Stroke

Jia

et al. 2011

Cerebrovasc Dis

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Background: Despite accumulating evidence supporting the association between variants of the ALOX5AP gene and atherosclerotic vascular events, the precise mechanism is still unclear. No variants in the coding sequence that lead to amino acid substitution have been found. We investigated genetic variants in the promoter region of the ALOX5AP gene and the association with ischemic stroke in a north Chinese Han population. Methods: 505 cases of ischemic stroke and 500 age- and gender-matched controls of the north Chinese Han population were enrolled. Genetic variants in the promoter region of the ALOX5AP gene were identified by polymerase chain reaction and DNA sequencing. 40 cases and 40 controls were randomly selected and compared for serum leukotriene B₄ (LTB₄) concentration. The effect on ischemic stroke was evaluated by logistic regression. Results: Three genetic variants were identified, including a mutation (–519 G > A), an insertion and deletion polymorphisms (–581_582 Ins A) and a single nuclear polymorphisms (–946 A > G). Association study showed that the II genotype of –581_582 Ins A was significantly associated with ischemic stroke of a large artery atherosclerosis (OR = 3.50, 95% CI = 1.93–6.36, p = 0.0002) and undetermined etiology (OR = 3.66, 95% CI = 1.92–6.94, p = 0.0006). No significant association was found between the –519 GA genotype (OR = 0.35, 95% CI = 0.02–5.88, p = 0.46), –946 AG genotype (OR = 1.35, 95% CI = 0.85–2.16, p = 0.21) and ischemic stroke. There was no significant difference in serum LTB₄ concentration between cases (n = 40) and controls (n = 40) (log serum LTB₄ of cases vs. controls: 2.67 ± 0.14 vs. 2.73 ± 0.18 pg/ml, p = 0.10). However, the serum LTB₄ concentration was significantly higher in participants with the II genotype of –581_582 Ins A (n = 12) than that of participants with the DD genotype (n = 68) (log serum LTB₄ of participants with II genotype vs. DD genotype: 2.82 ± 0.18 vs. 2.68 ± 0.15 pg/ml, p = 0.01). Conclusion: The –581_582 Ins A polymorphism might be a novel genetic risk factor for ischemic stroke in a north Chinese Han population. Further studies on molecular mechanism are warranted.

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The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease

Cited by 47 publications

References 35 publications

Renin–angiotensin system genes polymorphism in Egyptians with premature coronary artery disease

Renin–angiotensin system genes polymorphism in Egyptians with premature coronary artery disease

Research Article Assessment of the rs4340 ACE gene polymorphism in acute coronary syndrome in a Western Mexican population.

Genetic Variants in the Promoter Region of the <i>ALOX5AP</i> Gene and Susceptibility of Ischemic Stroke

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