This is a Response to a recent Comment [F.Y. Wu et al., Phil. Mag. 88, 3093 (2008), also arXiv:0811.3876] on the conjectured solution of the three-dimensional (3D) Ising model [Z.D. Zhang, Phil. Mag. 87, 5309 (2007)]. Several points are made: 1) Conjecture 1, regarding the additional rotation, is understood as performing a transformation for smoothing all the crossings of the knots; 2) The weight factors in Conjecture 2 are interpreted as a novel topologic phase; 3) The conjectured solution and its low-and high-temperature expansions are supported by the mathematical theorems for the analytical behavior of the Ising model. The physics behind the extra dimension is also discussed briefly.