The Ankle-Brachial Index as a Biomarker of Cardiovascular Risk

Perlstein, Todd S.; Creager, Mark A.

doi:10.1161/circulationaha.109.907238

Cited by 35 publications

(24 citation statements)

References 23 publications

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“…The ankle brachial index (ABI) is widely accepted as an established clinical test for the assessment of peripheral arterial disease (PAD) and an indicator of generalized atherosclerosis 10) . Furthermore, the greatest relevance of the ABI may not be for the limb but rather as a biomarker of cardiovascular risk 11,12) . A low ABI has been reported to associate with increased mortality and the risk of prevalent cardiovascular disease 13) .…”

Section: Introductionmentioning

confidence: 99%

Is Chronic Kidney Disease Associated with a High Ankle Brachial Index in Adults at High Cardiovascular Risk?

Líu

Shi

et al. 2011

JAT

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Section: Introductionmentioning

confidence: 99%

Is Chronic Kidney Disease Associated with a High Ankle Brachial Index in Adults at High Cardiovascular Risk?

Líu

Shi

et al. 2011

JAT

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“…Individuals with PAD are at significant risk for cardiovascular ischemic events, including myocardial infarction, stroke, and death (12,48). Epidemiological studies have shown that even asymptomatic patients suffer mortality rates significantly higher than individuals who do not have PAD.…”

Section: Ankle Brachial Indexmentioning

confidence: 99%

ACCF/AHA/ACR/SCAI/SIR/SVM/SVN/SVS 2010 Performance Measures for Adults With Peripheral Artery Disease

Olin¹,

Allie²,

Belkin³

et al. 2010

Journal of the American College of Cardiology

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“…Although an association between ABI and the prognosis of patients has recently been reported 51) , the relationship between TcPO2 and the prognosis remains unclear. Which of REST-TcPO2 (which is also affected by factors other than blood flow) and ExTcPO2 (which is directly affected by arterial stenosis, as is the case with ABI) is more useful as a predictor of the prognosis of PAD patients is a question of considerable interest that merits further study.…”

Section: Clinical Factors Affecting Tcpo2mentioning

confidence: 99%

Regions of Arterial Stenosis and Clinical Factors Determining Transcutaneous Oxygen Tension in Patients with Peripheral Arterial Disease

Ueno

Fukumoto

Koyama

et al. 2010

JAT

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Aims: Despite the clinical usefulness of transcutaneous oxygen tension (TcPO2) to assess the severity of limb ischemia, the factors determining TcPO2 in patients with peripheral arterial disease (PAD) have not been fully clarified. We therefore examined the regions of arterial stenosis and clinical factors affecting lower-extremity TcPO2. Methods: Resting TcPO2 (REST-TcPO2) and postexercise TcPO2 (Ex-TcPO2) in the calf region and the dorsalis pedis were measured simultaneously in 66 patients (132 limbs) with clinically suspected PAD, in whom angiography was also performed. Results: The peripheral arteries of the lower extremities were divided into five segments, and the impact of significant stenosis in each segment on ipsilateral TcPO2 was evaluated by multiple regression analysis. In the calf region, significant stenosis of the proximal arteries (common-external iliac artery) revealed stronger involvement determining Ex-TcPO2 than the peripheral segment (posterior tibial artery). In the dorsalis pedis, the peripheral segment (anterior tibial artery) more strongly determined Ex-TcPO2 and REST-TcPO2 than proximal segments. Age, creatinine, and diabetes were associated with REST-TcPO2 of the calf region independent of arterial stenoses, while those of the dorsalis pedis were independently associated with age, and creatinine. In contrast, Ex-TcPO2 in both regions was not independently associated with clinical factors, except for stenosis of the perfusing arteries. Conclusion: The vascular lesions affecting TcPO2 differ between the calf region (proximal peripheral) and the dorsalis pedis (proximal peripheral). In addition postexercise TcPO2 is solely determined by stenosis of the perfusing arteries, while TcPO2 at rest is affected by multiple clinical factors.J Atheroscler Thromb, 2010; 17:858-869.

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The Ankle-Brachial Index as a Biomarker of Cardiovascular Risk

Cited by 35 publications

References 23 publications

Is Chronic Kidney Disease Associated with a High Ankle Brachial Index in Adults at High Cardiovascular Risk?

Is Chronic Kidney Disease Associated with a High Ankle Brachial Index in Adults at High Cardiovascular Risk?

ACCF/AHA/ACR/SCAI/SIR/SVM/SVN/SVS 2010 Performance Measures for Adults With Peripheral Artery Disease

Regions of Arterial Stenosis and Clinical Factors Determining Transcutaneous Oxygen Tension in Patients with Peripheral Arterial Disease

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