The anorectic agent, lorcaserin, disturbs estrous cyclicity and produces endometrial hyperplasia without affecting ovarian population in female rats

Abdel-Latif, Raghda T.; Zaitone, Sawsan A.; Abdel–Mottaleb, Yousra; El-Maraghy, Nabila N.

doi:10.1016/j.lfs.2017.06.006

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…Different stages of estrus cycle (proestrus, estrus, metestrus, and diestrus) were monitored through the observed cellular types from the vaginal smear cytology of female rats (Figure 2(a)). The regular estrus cycle lasted for 4–5 days, including 1 day in proestrus, 1 day in estrus, and 2–3 days in diestrus [20, 21]. Significant changes were observed in each estrus cycle in the cold group compared with the control group (Figure 2(b)).…”

Section: Resultsmentioning

confidence: 99%

Impact of Cold Exposure on the Reproductive Function in Female Rats

Li²,

Lin

et al. 2018

BioMed Research International

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Female reproductive system diseases caused by exposure to a cold environment are widely considered as important human health challenges. Although the projection of female reproduction in cold temperature has been studied, a holistic view on the probable effects of cold exposure on the functions of the female reproductive system has not been achieved. Our aim was to evaluate the effects of cold exposure to the functions of the ovary and uterus in female rats. For this purpose, female rats were randomly grouped as follows: (1) the cold group was exposed to -10°C, 4 h per day for 2 weeks, and (2) the normal temperature (23 ± 1°C) group was used as control. Alterations were observed in different parameters, including body weight gain, organ coefficients, estrus cycle, and pathology of the cold-exposed female rats. Similarly, the serum reproductive hormones and mRNA expression were evaluated. Cold exposure induced estrus cycle irregularity and some alterations in the morphology of the ovary. Cold exposure impairs the function of the ovary probably by changing the level of serum LH and increasing LHR expression. Cold exposure induced a significant reduction of uterine epithelium height. Cold exposure causes alterations in the morphology of the uterus probably because of the effect of progesterone, the increase in the PR level, and the decrease in the ER level.

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Section: Resultsmentioning

confidence: 99%

Impact of Cold Exposure on the Reproductive Function in Female Rats

Li²,

Lin

et al. 2018

BioMed Research International

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“…The prepared smears were immediately immersed in a jar containing 70% alcohol for 1 or 2 min for fixation followed by rapid staining with 0.5% Loba chemie methylene blue solution (Mumbai, India) for 3 min. This was followed by washing with tap water and examined by a light microscope (33,34). The distinguishing phases of the cycle can be classified in the following as estrus (E), metestrus (M), diestrus (D), and proestrus (P).…”

Section: Detection Of Disturbances In Estrus Cyclicitymentioning

confidence: 99%

Evening Primrose Oil Ameliorates Hyperleptinemia and Reproductive Hormone Disturbances in Obese Female Rats: Impact on Estrus Cyclicity

et al. 2020

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Obesity is a public health burden disturbing all body functions and reproductive hormones. As obesity increases among females, there will be a rising challenge to physicians in care from fertility problems. Evening primrose oil (EPR oil) contains essential fatty acids including omega-6 linoleic acid with strong anti-inflammatory activity.Since EPR oil has utility in alleviating dysmenorrhea, this study aimed to ascertain its modulatory effect on systemic inflammation, reproductive hormones and estrus cycle irregularity in female obese rats. Thirty-two female rats were distributed to 4 groups: (i) normal, (ii) dietary obese-control female rats, and (iii and iv) dietary obese female rats treated with EPR oil (5 or 10 g/kg). Rats were examined for estrus regularity by taking vaginal smears daily during the last 2 weeks of the experiment. Serum level of insulin, leptin, adiponectin, and inflammatory cytokines was measured. In addition, serum lipid profile, and liver enzyme activities were estimated. Adipose tissues were taken for histopathologic examination as well as determination of gene expression for leptin, leptin receptors, adiponectin, and visfatin. Obese rats exhibited significant weight gain (90.69 ± 8.9), irregular prolonged estrus cycles (83.33%), increased serum levels of insulin, leptin, prolactin and testosterone and decreased gonadotropin levels. EPR oil exhibited a curative effect on obesity-related irregularity in estrus cycle and ovarian pathology. The underlying molecular mechanism may be related to reduction of systemic inflammation, alleviating insulin resistance and modulation of adipokine expression. EPR oil may be considered as a promising therapeutic intervention against obesity-related female hormonal disturbances and estrus irregularity.

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