The Anterior Border king of Schwalbe and the Pectinate Ligament

Cytochrome P450 1B1 (CYP1B1) is highly expressed in human and murine ocular tissues during development. Mutations in this gene are implicated in the development of primary congenital glaucoma (PCG) in humans. Mice deficient in Cyp1b1 (Cyp1b1−/−) present developmental abnormalities similar to human primary congenital glaucoma. The present work describes the ultrastructural morphology of the iridocorneal angle of 42 eyes from 1 week to 8-month-old Cyp1b1−/− mice. Morphometric and semiquantitative analysis of the data revealed that 3-week-old Cyp1b1−/− mice present significantly (p = 0.002) decreased amount of trabecular meshwork (TM) collagen and higher TM endothelial cell and collagen lesion scores (p = 0.002) than age-matched controls. Collagen loss and lesion scores were progressively increased in older animals with 8-month old animals presenting severe atrophy of the TM. Our findings advance the understanding of the effects of CYP1B1 mutations in the TM development and primary congenital glaucoma, and suggest a link between TM morphologic alterations and increased intraocular pressure.

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“…These developmental abnormalities resemble those reported in human patients with primary congenital glaucoma 14,15 .…”

Section: Discussionsupporting

confidence: 84%

Ultrastructural Abnormalities of the Trabecular Meshwork Extracellular Matrix in Cyp1b1-Deficient Mice

et al. 2014

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“…Cells intimately associated with the operculum often form clusters posteriorly within the anterior corneoscleral trabecular meshwork. They are known as Schwalbe line’s (SL) cells, named after their location on the anterior border ring of Schwalbe, and are considered a subpopulation of the trabecular cells within the iridocorneal angle 6 –8 . These cells have been found to be secretory in nature and might possibly function as stem cells for the trabecular meshwork.…”

Section: Introductionmentioning

confidence: 99%

Schwalbe line’s cell in the normal and glaucomatous dog

Samuelson

Plummer

Lewis

et al. 2001

Veterinary Ophthalmology

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“…The anatomy of the drainage system of the eye is well documented (Salzman 1912, Maggiore 191 7, Dvorak-Theobald 1934, 1954, Ashton 1951, Allen, Burian & Braley 1955, Ashton, Brini & Smith 1956, Flocks 1956, Brini 1959, Speakman 1959, Unger & Rohen 1959. However, the individual peculiarities of the morphology of this area are very considerable and they have not as yet been studied completely.…”

mentioning

confidence: 99%

Study on Morphology and Function of the Drainage Area of the Eye of Man

Нестеров

Batmanov

1972

Acta Ophthalmologica

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I n meridional sections, the anterior chamber angle is characterised by the width of the entrance into the angle, the shape of the apex, the configuration of the angle recess, and the position of the anterior part of the ciliary body. There are considerable variations in the morphology of the canal of Schlemm. The most important characteristics of the canal include the position of the sinus as regards the apex of the anterior chamber angle, the width of its lumen, and the inclination of the canal of Schlemm towards the anterior chamber. The meridional portion of the ciliary body usually reaches the scleral spur. However, in some eyes the posterior attachment of the ciliary muscle is located behind the scleral spur.In some presumably normal eyes, a partial blockage of the lumen of the Schlemm's canal was observed. Blockage was achieved experimentally on isolated eyes of man by increasing the pressure in the anterior chamber. The anterior position of the Schlemm's canal, the narrow scleral spur, and the posterior attachment of the ciliary muscle may be considered anatomical predispositions to blockage of the Schlemm's canal and the intertrabecular spaces.K e y words: anterior chamber angle -histology -aqueous.The drainage area of the eye contains the structures responsible for the outflow of the aqueous humor including the anterior chamber angle, the trabecular meshwork, the scleral spur, the canal of Schlemm and its outlets, the anterior part of the ciliary body, and the iris root.

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The Anterior Border king of Schwalbe and the Pectinate Ligament

Cited by 34 publications

References 2 publications

Ultrastructural Abnormalities of the Trabecular Meshwork Extracellular Matrix in Cyp1b1-Deficient Mice

Ultrastructural Abnormalities of the Trabecular Meshwork Extracellular Matrix in Cyp1b1-Deficient Mice

Schwalbe line’s cell in the normal and glaucomatous dog

Study on Morphology and Function of the Drainage Area of the Eye of Man

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