The anterior segment of the eye in diabetes

Adeoti, CO; Isawumi, MA; Ashaye, AO; Olomola, BV

doi:10.2147/opth.s27313

Cited by 9 publications

(9 citation statements)

References 21 publications

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“…Several anterior segment disorders were found in this study, similar to a previous study. 39 These ocular complications in DM are linked to the duration of disease 11 , 12 similar to our findings.…”

Section: Discussionsupporting

confidence: 88%

Dry eye disease and meibomian gland dysfunction among a clinical sample of type 2 diabetes patients in Ghana

Abu¹,

Ofori²,

Boadi-Kusi³

et al. 2022

Afr H. Sci.

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Objective: To evaluate dry eye disease and meibomian gland dysfunction among type 2 diabetes patients Methods: A hospital-based cross-sectional study was conducted. Parameters assessed included meibum expressibility and quality, Schirmer test 1, tear breakup time (TBUT), ocular surface staining, blink rates and Ocular Surface Disease Index (OSDI) scores. Dry eye was diagnosed based on a combination of subjective symptoms, tear function and ocular surface staining. Results: Prevalence of DED and MGD were 72.3% and 55.3% respectively. Symptomatic dry eye (OSDI scores) was significantly associated with duration of diabetes (rs = 0.11, P = 0.028) and the presence of conjunctival disorders (OR = 2.09, P = 0.002). MGD was a risk factor for DED (OR = 1.99, P = 0.008); ocular surface damage, the presence of eye lid lesions, abnormal Schirmer test and reduced TBUT were significantly associated with MGD, the strongest predictor being ocular surface damage (OR = 3.21, P = 0.001). OSDI scores had no association with the presence of corneal lesions possibly due to reduced corneal sensitivity. Conclusion: DED and MGD were prevalent among the patients and therefore there is the need for dry eye assessment as a routine clinical management protocol for patients with type 2 diabetes. Keywords: Dry eye disease; meibomian gland dysfunction; type 2 diabetes; Ghana.

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Section: Discussionsupporting

confidence: 88%

Dry eye disease and meibomian gland dysfunction among a clinical sample of type 2 diabetes patients in Ghana

Abu¹,

Ofori²,

Boadi-Kusi³

et al. 2022

Afr H. Sci.

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“…Other ophthalmic manifestations of DM include changes in lens transparency and premature cataract development, altered pharmacological mydriasis, orbital and lid features like cranial nerve palsies, chalazia, xanthelasma, and cellulitis, and conjunctival abnormalities comprising pterygia, pinguecula, tortuosity, and dilation of conjunctival vessels [11, 12].…”

Section: Introductionmentioning

confidence: 99%

Scheimpflug Camera and Swept-Source Optical Coherence Tomography in Pachymetry Evaluation of Diabetic Patients

Krysik¹,

Dobrowolski

Stanienda-Sokół

et al. 2019

Journal of Ophthalmology

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Aim. The comparative analysis of the central and peripheral corneal thicknesses using two different imaging systems: Scheimpflug camera and swept-source OCT was performed to investigate the differences in corneal thickness analysis in diabetic patients. Materials and Methods. The study group consisted of the 147 eyes of 107 diabetic patients who were examined and compared with 138 eyes of 89 nondiabetic cataract patients. The inclusion criteria for the study group was diabetes mellitus type II identified no less than 10 years ago, with NPDR not requiring prior laser treatment. The control group was recruited from nondiabetic patients. Measurements were obtained on the Pentacam Scheimpflug imaging system and Casia swept-source OCT. All study parameters from anterior chamber images were processed for five different zones, the central zone and four peripherals—superior, inferior, nasal, and temporal. A fit zone diameter of 4 mm was applied for both instruments. Results. The Pentacam system overestimated corneal measurements in the DM group when compared with the Casia OCT in superior corneal zone (p=0.04), inferior corneal zone (p=0.02), nasal corneal zone (p<0.001), and temporal corneal zone (p=0.01). In the control group, there were also statistically significant differences between the Pentacam and Casia OCT measured values in inferior corneal zone (p=0.001), nasal corneal zone (p=0.04), and temporal corneal zone (p<0.001). Conclusion. Scheimpflug camera pachymetry measurements showed statistically higher CCT values when compared with swept-source OCT measurements.

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“…Diabetes may affect the anterior segment triggering the development of cataracts, dry eye syndrome, corneal ulcers, warts, tortuous conjunctival vessels, and keratopathy [4,21]. In the posterior segment, diabetes may contribute to glaucoma, retinopathy, and macular edema [22].…”

Section: Diabetic Eye Diseasesmentioning

confidence: 99%

Diabetic eye: associated diseases, drugs in clinic, and role of self-assembled carriers in topical treatment

Kattar

Concheiro

Alvarez‐Lorenzo

2021

Expert Opinion on Drug Delivery

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Introduction: Diabetes is a pandemic disease that causes relevant ocular pathologies. Diabetic retinopathy, macular edema, cataracts, glaucoma, or keratopathy strongly impact the quality of life of the patients. In addition to glycemic control, intense research is devoted to finding more efficient ocular drugs and improved delivery systems that can overcome eye barriers. Areas covered: The aim of this review is to revisit first the role of diabetes in the development of chronic eye diseases. Then, commercially available drugs and new candidates in clinical trials are tackled together with the pros and cons of their administration routes. Subsequent sections deal with self-assembled drug carriers suitable for eye instillation combining patient-friendly administration with high ocular bioavailability. Performance of topically administered polymeric micelles, liposomes, and niosomes for the management of diabetic eye diseases is analyzed in the light of ex vivo and in vivo results and outcomes of clinical trials. Expert opinion: Self-assembled carriers are being shown useful for efficient delivery of not only a variety of small drugs but also macromolecules (e.g. antibodies) and genes. Successful design of drug carriers may offer alternatives to intraocular injections and improve the treatment of both anterior and posterior segments diabetic eye diseases.

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The anterior segment of the eye in diabetes

Cited by 9 publications

References 21 publications

Dry eye disease and meibomian gland dysfunction among a clinical sample of type 2 diabetes patients in Ghana

Dry eye disease and meibomian gland dysfunction among a clinical sample of type 2 diabetes patients in Ghana

Scheimpflug Camera and Swept-Source Optical Coherence Tomography in Pachymetry Evaluation of Diabetic Patients

Diabetic eye: associated diseases, drugs in clinic, and role of self-assembled carriers in topical treatment

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