The anthelmintic effect of aqueous methanol extract of Combretum molle (R. Br. x. G. Don) (Combretaceae) in lambs experimentally infected with Haemonchus contortus

Simon, M.K.; Ajanusi, O.J.; Abubakar, M.S.; Idris, Abdullah; Сулейман, М. М.

doi:10.1016/j.vetpar.2011.12.022

Cited by 15 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The decreased EPG value after treatment was the same as the results of research conducted by Simon et al [35], who stated that Combretum molle extract decreased the FEC in sheep infected with H. contortus. González-Cortazar et al [36] stated that the aqueous extract of L. acapulcensis leaves reduced the EPG value of gastrointestinal nematodes in sheep.…”

Section: Discussionsupporting

confidence: 87%

“…The decrease in the EPG value is believed to be caused by secondary compounds in I. tinctoria. The presence of flavonoids, tannins, saponins, and alkaloids in C. molle may be responsible for the anthelmintic effect of these plants [35]. González-Cortazar et al [36] added that myricitrin (a flavonoid) is the main component for reducing the EPG value.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anthelmintic effect of Indigofera tinctoria L on Haemonchus contortus obtained from sheep in Indonesia

et al. 2021

View full text Add to dashboard Cite

Background and Aim: Hemonchosis has resulted in huge economic losses for sheep farmers worldwide. Secondary metabolite compounds from Indigofera tinctoria L. can be used as anthelmintics. This study aimed to evaluate the in vitro and in vivo effects of I. tinctoria L. aqueous extract (IAE) as an anthelmintic against adult Haemonchus contortus isolated from sheep. Materials and Methods: Ten active adult worms were placed in each Petri dish containing 25 mL of IAE, each having a different concentration of IAE (at concentrations 100, 120, 140, 160, 180, 200, and 220 mg/mL). Each experiment was repeated. The positive control used 1% albendazole, and the negative control used 0.62% saline water. The number of immobile worms and the time of mortality were recorded after 2, 4, 6, and 8 h. The dead worms were subsequently tested using scanning electron microscopy (SEM) and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In the in vivo study, 15 sheep with an average fecal egg count (FEC) of 1000 eggs per gram were treated with IAE for 9 days: Group A (negative control, saline water 0.62%), Group B (21 mg/mL), Group C (41 mg/mL), Group D (62 mg/mL), and Group E (positive control, albendazole 100 mg/mL). Measurements of the body weight, FEC reduction test, and hematology testing were performed on days 0, 7, and 14. SEM was performed using worms found from the abomasum of slaughtered sheep. Results: The leaves of I. tinctoria L. contained a number of secondary metabolites, including total tannins, saponins, flavonoids, and alkaloids. The most effective concentration that killed the adult H. contortus worms was 220 mg/mL (93.33% mortality) after 8 h of treatment. The electrophoresis results showed that the protein band at a dose of 22% was less than that of the control. The highest FECR value of the treatment group on the 14th day after treatment was at a dose of 62 mg/mL. The highest weight gain as well as the highest increased hemoglobin (Hb), packed cell volume (PCV), and total erythrocyte count (TEC) values on the 14th day after treatment were at a dose of 41 mg/mL. The SEM results showed that IAE treatment caused the worms' anterior parts to become wrinkled with thick creases and cuticle abrasion (in vitro) and the anterior part to shrink along with the presence of aggregates in the worm cuticle (in vivo). Conclusion: The aqueous extract of I. tinctoria contains tannins, saponins, flavonoids, and alkaloids and has an anthelmintic effect with decreased FEC, increased weight gain, Hb, PCV, and TEC, causing damage to the worms' body and reducing the protein profile of adult H. contortus worms.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Anthelmintic effect of Indigofera tinctoria L on Haemonchus contortus obtained from sheep in Indonesia

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Ex G. Don (Combretaceae) is popularly used in most African countries for the treatment of stomach pain, dysentery, gastric ulcers, abdominal disorders, and other illnesses (Eloff et al, 2008;Njume et al, 2011). The anthelmintic (Simon et al, 2012), antibacterial, and antifungal effects (Asres et al, 2006) Njume et al, 2011).…”

Section: Combretum Mollementioning

confidence: 99%

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Safavi

Shams-Ardakani

Foroumadi

2014

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Helicobacter pylori is a small, spiral, Gram-negative bacillus that plays a role in the pathogenesis of a number of diseases ranging from asymptomatic gastritis to gastric cancer. Schedule compliance, antibiotic drug resistance, and side-effects of triple or quadruple therapy have led to research for novel candidates from plants.Objective: The purpose of this paper is to review the most potent medicinal plants of recently published literature with anti-H. pylori activity. For centuries, herbals have been used by traditional healers around the world to treat various gastrointestinal tract disorders such as dyspepsia, gastritis, and peptic ulcer disease. The mechanism of action by which these botanicals exert their therapeutic properties has not been completely and clearly elucidated. Anti-H. pylori properties may be one of the possible mechanisms by which gastroprotective herbs treat gastrointestinal tract disorders. Materials and methods: Electronic databases such as PubMed, Google scholar, EBSCO, and local databases were explored for medicinal plants with anti-H. pylori properties between 1984 and 2013 using key words ''medicinal plants'' and ''Helicobacter pylori'' or ''anti-Helicobacter pylori''. Results: A total of 43 medicinal plant species belonging to 27 families including Amaryllidaceae,

show abstract

“…Antifungal activity against Candida albicans, antiviral activity against Herpes simplex 1 and Herpes simplex 2, antimalarial activity against Plasmodium falciparum and antidiabetic activity was also reported [8][9][10][11]. C. molle has also demonstrated antibacterial, antifungal, anthelmintic, antiasthmatic and antitussive activities [12][13][14]. Extracts of C. erythrophyllum obtained with different solvents (acetone, hexane, chloroform, carbon tetrachloride and butanol) have shown antibacterial activity at different doses against Escherichia coli, P. aeruginosa, S. aureus and Enterococcus faecalis [15,16].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Constituents of Combretum Loefl. (Combretaceae)

Dawe¹

2013

TOPHARMCJ

View full text Add to dashboard Cite

Abstract:Combretum is the largest and most widespread genus of Combretaceae. The genus comprises approximately 250 species distributed throughout the tropical regions mainly in Africa and Asia. With increasing chemical and pharmacological investigations, Combretum has shown its potential as a source of various secondary metabolites. Combretum extracts or isolates have shown in vitro bioactivitities such as antibacterial, antifungal, antihyperglycemic, cytotoxicity against various human tumor cell lines, anti-inflammatory, anti-snake, antimalarial and antioxidant effects. In vivo studies through various animal models have also shown promising results. However, chemical constituents and bioactivities of most species of this highly diversified genus have not been investigated. The molecular mechanism of bioactivities of Combretum isolates remains elusive. This review focuses on the chemistry of 261 compounds isolated and identified from 31 species of Combretum. The phytochemicals of interest are non-essential oil compounds belonging to the various structural groups such as terpenoids, flavonoids, phenanthrenes and stilbenoids.

show abstract

The anthelmintic effect of aqueous methanol extract of Combretum molle (R. Br. x. G. Don) (Combretaceae) in lambs experimentally infected with Haemonchus contortus

Cited by 15 publications

References 13 publications

Anthelmintic effect of Indigofera tinctoria L on Haemonchus contortus obtained from sheep in Indonesia

Anthelmintic effect of Indigofera tinctoria L on Haemonchus contortus obtained from sheep in Indonesia

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Phytochemical Constituents of Combretum Loefl. (Combretaceae)

Contact Info

Product

Resources

About