THE ANTHELMINTIC EFFICACY OF HALF‐DOSE RATES OF LEVAMISOLE AGAINST BENZIMIDAZOLE RESISTANT <i>HAEMONCHUS CONTORTUS</i>

Forsyth, B. A.; Gibbon, AJ

doi:10.1111/j.1751-0813.1980.tb05692.x

Cited by 5 publications

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“…The significant loss of efficacy of the two nonbenzimidazole broad spectrum anthelrnintics, levamisole and morantel tartrate, against the Lawes strain, contrasts with the high activity reported previously against benzimidazole resistant strains of H. contortus (Campbell et a/ 1978;Kelly and Hall 1979a;Forsyth and Gibbon 1980).…”

Section: Resultsmentioning

confidence: 63%

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THE ISOLATION OF A FIELD STRAIN OF HAEMONCHUS CONTORTUS IN QUEENSLAND SHOWING MULTIPLE ANTHELMINTIC RESISTANCE

Green

Forsyth²,

Rowan³

et al. 1981

Aust Veterinary J

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Following the apparent failure of levamisole to control infections of Haemonchus contortus in sheep at Lawes in south eastern Queensland, a strain of this parasite was isolated at the Animal Research Institute, Yeerongpilly. This strain was used to infect sheep at Yeerongpilly and the Merrindale Research Station, Victoria where four experiments to classify the resistance pattern of the parasite were carried out. Resistance to thiabendazole was first suspected in 1969, and these experiments confirmed that resistance to this drug was still present. They also showed that a strong degree of resistance had been developed to both levamisole and morantel tartrate. Other benzimidazole anthelmintics and also the organophosphorus compound naphthalophos were only moderately effective against the original isolate but rafoxanide, nitroxynil and phenothiazine were almost 100% effective. Other highly effective chemicals were disophenol and closantel. After passaging the strain for four generations with both levamisole and albendazole, resistance to both naphthalophos and the newer benzimidazole anthelmintics increased dramatically. This is the first report of a field strain of H. contortus exhibiting resistance to benzimidazole, non-benzimidazole and organophosphorus anthelmintics.

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Section: Resultsmentioning

confidence: 63%

“…Levamisole and morantel tartrate have been s h o w n to b e h i g h l y e f f e c t i v e a g a i n s t benzimidazole-resistant H . contortus (Campbell et af 1978;Coles et a/ 1979;Forsyth and Gibbon 1980) but Le Jambre et af (1976) have demonstrated potential for resistance to these drugs in laboratory selected strains of this parasite.…”

Section: Introductionmentioning

confidence: 99%

THE ISOLATION OF A FIELD STRAIN OF HAEMONCHUS CONTORTUS IN QUEENSLAND SHOWING MULTIPLE ANTHELMINTIC RESISTANCE

Green

Forsyth²,

Rowan³

et al. 1981

Aust Veterinary J

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“…Щодо препаратів групи імідотіазолів стійкими виявилися нематоди видів Ostertagia consisting, O. circumcincta, O. trifurcata (Jambre, 1979), Haemonchus contortus (Forsyth & Gibbon, 1980) та роду Trichostrongylus (Webb, & Ottaway, 1986). Водночас нематоди Haemonchus contortus та Trichostrongylus sp.…”

Section: вступunclassified

Effectiveness of modern anthelmintic agents for strongylatoses sheep digestive canal

Мельничук

2019

SMLNUVMB

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Currently, the use of anthelmintic agents is considered to be one of the fastest and most practical ways to combat strongylates sheep's digestive tract. Despite the wide assortment of anthelmintic preparations both in the world market and in Ukraine, veterinary specialists are increasingly noticing the low level of efficacy of medicines. Scientists have found that the emergence of resistance in nematodes to the action of anthelmintic agents is due to their excessive and uncontrolled use. In view of the above, regular monitoring of the state of anthelmintic resistance, as part of the program for the control of strongylatoses sheep digestive canal, is a priority area of research. Therefore, the purpose of the study was to evaluate the anthelmintic efficacy of drugs of different chemical groups (benzimidazoles, imidotiazole, macrolides, and combination drugs) for strongylatoses sheep digestive canal with regard to their method of administration. Medicines (Brovalsen, Albendazole-250, Albendazole 10%; Brovalevamisole 8%, Levavet 10%; Univerm, Ivermekvet 1%; Kloziveron, Kombitrem) have been shown to have anthelmintic action (EE – 50–100%, IE – 76.20–100%) against the pathogens of gastrointestinal strongylates. It was noted that their effectiveness depended on the method of administration and the chemical group to which they belonged. The most effective (EE and IE reached 100%) were injectable drugs Ivermekvet 1%, Kloziveron and Levavet 10 %, administered by single subcutaneous injection. Less effective was the use of a suspension of Albendazole 10% and Kombitrem emulsion for individual feeding, as well as powders of Brovalevamisole 8% and the Univerm for both individual and group feeding. The indicators of their EE and IE varied between 60–90% and 88.45–92.63% respectively. The Brovalsen drug, which was administered to animals by group feeding, was ineffective, with EE and IE being 50 and 76.20%, respectively. The results of the obtained data will allow to increase the efficiency of conducting therapeutic and preventive measures for strongylatoses digestive canal in sheep farms of different forms of ownership.

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“…These results again support the concept that worm control programs relying o n broad spectrum anthelmintics should stress the importance of using the full recommended dose (or perhaps more) to remove as many worms as possible from the host (Le Jambre 1978). Recommendations that half doses of anthelmintic be used against H . conforfus outbreaks (Forsyth and Gibbon 1980) apparently d o not consider the fact that other species of parasites such a s 0. circumcincia, which have a higher natural tolerance to anthelmintics than H. conforius, may also be present in lesser numbers. Thus the risk of selecting for resistance in these nontarget species is likely to be increased if half doses of anthelmintic are used.…”

Section: Leakage Of Plasma Proteins Onto the Skin Surface Of Sheep Dumentioning

confidence: 99%

Active Immunisation of Horses Against Tetanus Including the Booster Dose and Its Application

Liefman

1981

Aust Veterinary J

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Successful active immunisation of horses against tetanus is dependent on a number of factors of which the toxoid preparation used, its method of application and the ability of the individual horse to respond are fundamental. Two immunisation schedules using an aluminium-based toxoid preparation were examined and the protection determined by monitoring the level of antitoxin afforded by each schedule. The results obtained demonstrated that 2 doses of this toxoid are necessary to ensure 12 months protection in all horses. These results are discussed in relation to the factors involved in active immunisation against tetanus. Reference is also made to the occurrence of a transient phase of reduced levels of antitoxin following booster doses of toxoid in immunised horses during which it is considered these horses could become more susceptible to tetanus. The effect of a booster dose on immunised horses was examined and while there can be a reduction in the level of antitoxin in some immunised horses following this dose its effect is minimal, short-lived and for all practical purposes can be disregarded. The application of the booster dose in practice is also discussed.

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THE ANTHELMINTIC EFFICACY OF HALF‐DOSE RATES OF LEVAMISOLE AGAINST BENZIMIDAZOLE RESISTANT HAEMONCHUS CONTORTUS

Cited by 5 publications

References 0 publications

THE ISOLATION OF A FIELD STRAIN OF HAEMONCHUS CONTORTUS IN QUEENSLAND SHOWING MULTIPLE ANTHELMINTIC RESISTANCE

THE ISOLATION OF A FIELD STRAIN OF HAEMONCHUS CONTORTUS IN QUEENSLAND SHOWING MULTIPLE ANTHELMINTIC RESISTANCE

Effectiveness of modern anthelmintic agents for strongylatoses sheep digestive canal

Active Immunisation of Horses Against Tetanus Including the Booster Dose and Its Application

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