The anti-biofouling effect of<i>Lactobacillus fermentum</i>-derived biosurfactant against<i>Streptococcus mutans</i>

Tahmourespour, Arezoo; Salehi, Roya; Kermanshahi, R Kasra; Eslami, Gilda

doi:10.1080/08927014.2011.575458

Cited by 67 publications

(42 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, it presents antimicrobial activity against several microorganisms involved in diseases and infections in the urinary, vaginal and gastrointestinal tracts (Gudiña et al [2010a]). The chemical composition of this biosurfactant (herein named BioEG) was studied and it was found to be a glycoprotein (Pinto et al [2011]), which is in good agreement with the general composition reported for biosurfactants obtained from lactic acid bacteria (Brzozowski et al [2011]; Golek et al [2009]; Madhu and Prapulla [2013]; Moldes et al [2013]; Tahmourespour et al [2011a]; [2011b]).…”

Section: Introductionsupporting

confidence: 67%

Effects of biosurfactants on the viability and proliferation of human breast cancer cells

et al. 2014

View full text Add to dashboard Cite

Biosurfactants are molecules with surface activity produced by microorganisms that can be used in many biomedical applications. The anti-tumour potential of these molecules is being studied, although results are still scarce and few data are available regarding the mechanisms underlying such activity. In this work, the anti-tumour activity of a surfactin produced by Bacillus subtilis 573 and a glycoprotein (BioEG) produced by Lactobacillus paracasei subsp. paracasei A20 was evaluated. Both biosurfactants were tested against two breast cancer cell lines, T47D and MDA-MB-231, and a non-tumour fibroblast cell line (MC-3 T3-E1), specifically regarding cell viability and proliferation. Surfactin was found to decrease viability of both breast cancer cell lines studied. A 24 h exposure to 0.05 g l-1 surfactin led to inhibition of cell proliferation as shown by cell cycle arrest at G1 phase. Similarly, exposure of cells to 0.15 g l-1 BioEG for 48 h decreased cancer cells’ viability, without affecting normal fibroblasts. Moreover, BioEG induced the cell cycle arrest at G1 for both breast cancer cell lines. The biosurfactant BioEG was shown to be more active than surfactin against the studied breast cancer cells. The results gathered in this work are very promising regarding the biosurfactants potential for breast cancer treatment and encourage further work with the BioEG glycoprotein.

show abstract

Section: Introductionsupporting

confidence: 67%

Effects of biosurfactants on the viability and proliferation of human breast cancer cells

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In the presence of S. mutans , the above-mentioned ability to form a derivative was inhibited, probably due to the inhibition of two key enzymes, GtfB and GtfC. A decrease in the gene expression encoding the mentioned glucosyltransferases in the presence of a biosurfactant derivative produced by L. fermentum [70, 71] has been reported. Ogawa et al noted that S. salivarius can inhibit biofilm formation.…”

Section: Interbacterial Interactions and The Process Of Biofilm Formamentioning

confidence: 99%

The virulence of Streptococcus mutans and the ability to form biofilms

Krzyściak

Jurczak

Kościelniak

et al. 2013

Eur J Clin Microbiol Infect Dis

475

343

View full text Add to dashboard Cite

In some diseases, a very important role is played by the ability of bacteria to form multi-dimensional complex structure known as biofilm. The most common disease of the oral cavity, known as dental caries, is a top leader. Streptococcus mutans, one of the many etiological factors of dental caries, is a microorganism which is able to acquire new properties allowing for the expression of pathogenicity determinants determining its virulence in specific environmental conditions. Through the mechanism of adhesion to a solid surface, S. mutans is capable of colonizing the oral cavity and also of forming bacterial biofilm. Additional properties enabling S. mutans to colonize the oral cavity include the ability to survive in an acidic environment and specific interaction with other microorganisms colonizing this ecosystem. This review is an attempt to establish which characteristics associated with biofilm formation—virulence determinants of S. mutans—are responsible for the development of dental caries. In order to extend the knowledge of the nature of Streptococcus infections, an attempt to face the following problems will be made: Biofilm formation as a complex process of protein–bacterium interaction. To what extent do microorganisms of the cariogenic flora exemplified by S. mutans differ in virulence determinants “expression” from microorganisms of physiological flora? How does the environment of the oral cavity and its microorganisms affect the biofilm formation of dominant species? How do selected inhibitors affect the biofilm formation of cariogenic microorganisms?

show abstract

“…Very few studies have been contributed toward understanding the role of Lactobacillus ‐derived BS on gene expression conferring the virulence properties to biofilm forming bacteria. For example, Tahmourespour et al initiated studies (discussed previously) and later demonstrated by Salehi et al indicating the effects of cell associated biosurfactant purified from L. reuteri (DSM20016) on the gene expression profile of essential adhesion genes (gftB/C and ftf ,) in S. mutans (ATCC35668). The cell associated biosurfactant (structure not described) has been proved as potential inhibitor of the glucosyltransferases and fructosyltransferase in S. mutans (ATCC35668).…”

Section: The Success Story Of Surlactinmentioning

confidence: 99%

Biosurfactant/s from Lactobacilli species: Properties, challenges and potential biomedical applications

Satpute

Kulkarni

Banpurkar

et al. 2016

J. Basic Microbiol.

147

115

View full text Add to dashboard Cite

Lactic acid bacteria are generally believed to have positive roles in maintaining good health and immune system in humans. A number of Lactobacilli spp. are known to produce important metabolites, among which biosurfactants in particular have shown antimicrobial activity against several pathogens in the intestinal tract and female urogenital tract partly through interfering with biofilm formation and adhesion to the epithelial cells surfaces. Around 46 reports are documented on biosurfactant production from Lactobacillus spp. of which six can be broadly classified as cell free biosurfactant and 40 as cell associated biosurfactants and only approximately 50% of those have reported on the structural composition which, in order of occurrence were mainly proteinaceous, glycolipidic, glycoproteins, or glycolipopeptides in nature. Due to the proteinaceous nature, most biosurfactant produced by strains of Lactobacillus are generally believed to be surlactin type with high potential toward impeding pathogens adherence. Researchers have recently focused on the anti-adhesive and antibiofilm properties of Lactobacilli-derived biosurfactants. This review briefly discusses the significance of Lactobacilli-derived biosurfactants and their potential applications in various fields. In addition, we highlight the exceptional prospects and challenges in fermentation economics of Lactobacillus spp.-derived biosurfactants' production processes.

show abstract

The anti-biofouling effect ofLactobacillus fermentum-derived biosurfactant againstStreptococcus mutans

Cited by 67 publications

References 45 publications

Effects of biosurfactants on the viability and proliferation of human breast cancer cells

Effects of biosurfactants on the viability and proliferation of human breast cancer cells

The virulence of Streptococcus mutans and the ability to form biofilms

Biosurfactant/s from Lactobacilli species: Properties, challenges and potential biomedical applications

Contact Info

Product

Resources

About