The anti-estrogenic activity of indole-3-carbinol in neonatal rat osteoblasts is associated with the estrogen receptor antagonist 2-hydroxyestradiol

Abstract

This study is the first to show that a bioactive compound derived from cruciferous vegetables, I3C, abolishes the E2-mediated stimulation of cell activities including, proliferation and differentiation, in rat osteoblasts and increases the 2-hydroxylation of E1, resulting in the formation of inactive and anti-estrogenic metabolites. These results suggest that in neonatal rat osteoblasts, the anti-estrogenic effect of I3C is mediated by 2-OHE2 through ER-α.

Agrivoltaic Systems Enhance Farmers’ Profits through Broccoli Visual Quality and Electricity Production without Dramatic Changes in Yield, Antioxidant Capacity, and Glucosinolates

“…Thus, there may be a difference between AOP gene expression, DTH, and photosynthetic photon flux during the three different seasons. Glucobrassicin is a precursor of indole-3-carbinol, which is reported to possess various bioactive compounds, including some that have anti-obese [33], anticancer [34,35], and anti-extrogenic effects [36,37]. There was no significant difference in glucobrassicin concentration among treatments as well as seasons (Supplementary Figure S1C).…”

Current results on the biological and pharmacological activities of indole-3-carbinol

“…Here, we summarize recent studies performed to evaluate the biological and pharmacological activities of I3C (Table 1 (Tab. 1) ; References in Table 1: Mohammadi et al, 2017[ 27 ]; Ampofo et al, 2017[ 1 ]; Hammerschmidt-Kamper et al, 2017[ 16 ]; Safa et al, 2017[ 31 ]; Kabel et al, 2017[ 19 ]; Sherer et al, 2017[ 33 ]; Gehrcke et al, 2017[ 15 ]; Quirit et al, 2017[ 30 ]; Fletcher et al, 2017[ 12 ]; Julliard et al, 2017[ 18 ]; Kundu et al, 2017[ 21 ]; Wang et al, 2016[ 35 ]; Megna et al, 2016[ 26 ]; El-Naga and Mahran, 2016[ 10 ]; Enríquez et al, 2016[ 11 ]; Poindexter et al, 2016[ 29 ]; Song et al, 2015[ 34 ]; Lin et al, 2015[ 23 ]; Busbee et al, 2015[ 4 ]; Safa et al, 2015[ 32 ]; Wang et al, 2015[ 36 ]; Caruso et al, 2014[ 6 ]; Perez-Chacon et al, 2014[ 28 ]; Aronchik et al, 2014[ 2 ]; Chen et al, 2014[ 7 ]; Choi et al, 2014[ 8 ]; Mao et al, 2014[ 24 ]; Jayakumar et al, 2014[ 17 ]; Brandt et al, 2014[ 3 ]; Busbee et al, 2014[ 5 ]).…”