The Anti-Hyperglycemic Effect of Plants in Genus <i>Gynura</i> Cass.

Li, Weilin; Ren, Bingru; Min-Zhuo,; Hu, Yong; Chang-gen, Lu; Wu, Julan; Chen, Jian; Sun, Sihao

doi:10.1142/s0192415x09007430

Cited by 43 publications

(21 citation statements)

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“…Many Gynura species have recently been shown to exhibit hypoglycemic and carbohydrate enzyme inhibitory activities [11–14]. The inhibition of yeast α-glucosidase activity of the extracts and pure phenolic compounds 1 – 7 were determined.…”

Section: Resultsmentioning

confidence: 99%

Yeast α-Glucosidase Inhibitory Phenolic Compounds Isolated from Gynura medica Leaf

Tan

Wang

Luo

et al. 2013

IJMS

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Gynura medica leaf extract contains significant amounts of flavonols and phenolic acids and exhibits powerful hypoglycemic activity against diabetic rats in vivo. However, the hypoglycemic active constituents that exist in the plant have not been fully elaborated. The purpose of this study is to isolate and elaborate the hypoglycemic activity compounds against inhibition the yeast α-glucosidase in vitro. Seven phenolic compounds including five flavonols and two phenolic acids were isolated from the leaf of G. medica. Their structures were identified by the extensive NMR and mass spectral analyses as: kaempferol (1), quercetin (2), kaempferol-3-O-β-D-glucopyranoside (3), kaempferol-3-O-rutinoside (4), rutin (5), chlorogenic acid (6) and 3,5-dicaffeoylquinic acid methyl ester (7). All of the compounds except 1 and 3 were isolated for the first time from G. medica. Compounds 1–7 were also assayed for their hypoglycemic activity against yeast α-glucosidase in vitro. All of the compounds except 1 and 6 showed good yeast α-glucosidase inhibitory activity with the IC50 values of 1.67 mg/mL, 1.46 mg/mL, 0.38 mg/mL, 0.10 mg/mL and 0.53 mg/mL, respectively.

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Section: Resultsmentioning

confidence: 99%

Yeast α-Glucosidase Inhibitory Phenolic Compounds Isolated from Gynura medica Leaf

Tan

Wang

Luo

et al. 2013

IJMS

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“…Scientific studies on the use of locally grown G. bicolor to ensure its efficacy and nontoxicity have not been carried out. Several phytochemical and biological reports showed that G. bicolor cultivated in Japan, China, and Taiwan has antihyperglycemic effect [2, 4], anti-inflammation activity [5], and antioxidant capacity [6] and could induce apoptosis in HL60 leukemia cells [7]. Chemical constituents such as flavonols, anthocyanins, sesquiterpenes, terpenes, and megastigmane-type norisoprenoids had also been isolated from G. bicolor leaves [3, 8–10].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Capacity, Cytotoxicity, and Acute Oral Toxicity ofGynura bicolor

Teoh

Sim

Richardson

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Gynura bicolor (Compositae) which is widely used by the locals as natural remedies in folk medicine has limited scientific studies to ensure its efficacy and nontoxicity. The current study reports the total phenolic content, antioxidant capacity, cytotoxicity, and acute oral toxicity of crude methanol and its fractionated extracts (hexane, ethyl acetate, and water) of G. bicolor leaves. Five human colon cancer cell lines (HT-29, HCT-15, SW480, Caco-2, and HCT 116), one human breast adenocarcinoma cell line (MCF7), and one human normal colon cell line (CCD-18Co) were used to evaluate the cytotoxicity of G. bicolor. The present findings had clearly demonstrated that ethyl acetate extract of G. bicolor with the highest total phenolic content among the extracts showed the strongest antioxidant activity (DPPH radical scavenging assay and metal chelating assay), possessed cytotoxicity, and induced apoptotic and necrotic cell death, especially towards the HCT 116 and HCT-15 colon cancer cells. The acute oral toxicity study indicated that methanol extract of G. bicolor has negligible level of toxicity when administered orally and has been regarded as safe in experimental rats. The findings of the current study clearly established the chemoprevention potential of G. bicolor and thus provide scientific validation on the therapeutic claims of G. bicolor.

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“…The pooled analyses indicated that Tangminling pill was more efficacious in decreasing glucose level, body weight, and improving β-cell function, with no more drug-related adverse events, than placebo treatment in T2DM patients. Traditional Chinese medications, mainly edible herbs, have been widely used in clinical practice in China for more than 2000 years [16][17][18] (Table 3). Three bioactive alkaloids have been isolated from Rhizoma coptidis, including berberine, coptisine, and jatrorrhizine.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of traditional Chinese medication Tangminling pill in Chinese patients with type 2 diabetes

et al. 2019

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The morbidity of type 2 diabetes mellitus (T2DM) has been increasing rapidly worldwide. Tangminling pill, consisting of ten Chinese herbal medications, is usually prescribed for T2DM in mainland China. Whether treatment with Tangminling can improve clinical outcomes of T2DM patients was still debated. Four studies comparing Tangminling vs. placebo treatment in T2DM patients were included and 767 T2DM patients were enrolled in our analyses. Tangminling treatment exhibited better efficacy than placebo in reducing hemoglobin A1c (HbA1c) (1.11 vs. 0.32%; pooled weighted mean difference [WMD]: 0.80; 95% confidence interval [CI]: 0.65–0.96; P<0.001), fasting plasma glucose (0.82 vs. −0.40 mM; WMD: 1.10; 95% CI: 0.56–1.64; P<0.001), 2-h postprandial glucose (2-hr PG) (2.81 vs. 1.11 mM; WMD: 1.80; 95% CI: 1.72–1.88; P<0.001), homeostatic model assessment-β level (4.28 vs. 0.41; WMD: 0.44; 95% CI: 0.27–0.61; P<0.001), waist circumference (WC) (1.04 vs. 0.36 cm; WMD: 0.78; 95% CI: 0.37–1.19; P<0.001) and body weight index (0.37 vs. 0.11 kg/m2; WMD: 0.30; 95% CI: −0.00 to 0.61; P=0.05). Tangminling pill might reduce glucose level and body weight and improve β-cell function in T2DM patients. Our study highlights the important role of Tangminling pill in the management of T2DM.

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The Anti-Hyperglycemic Effect of Plants in Genus Gynura Cass.

Cited by 43 publications

References 1 publication

Yeast α-Glucosidase Inhibitory Phenolic Compounds Isolated from Gynura medica Leaf

Yeast α-Glucosidase Inhibitory Phenolic Compounds Isolated from Gynura medica Leaf

Antioxidant Capacity, Cytotoxicity, and Acute Oral Toxicity ofGynura bicolor

Efficacy of traditional Chinese medication Tangminling pill in Chinese patients with type 2 diabetes

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