The Anti-Inflammatory Action of Griseofulvin in Experimental Animals

Abstract

When tested by the cotton‐pellet method in rats or the tuberculin‐hypersensitivity test in guinea pigs, griseofulvin had a marked antiinflammatory action. The activity was, weight for weight, less than that of the corticosteroids tested concurrently. The anti‐inflammatory action of griseofulvin appears to be independent of any effect upon the pituitary‐adrenal axis.

In Vitro and In Vivo Studies of Ambruticin (W7783): New Class of Antifungal Antibiotics

“…4) 3 postinfection, ambruticin was adninistered orally at 40 mg/kg twice daily for a total of 10 days. On postinfection day 15 (3 days off drug), the guinea pig mean lesion score was approximately 1.3; by postinfection day 27 (15 days off drug), all the lesions were essentially healed (Fig.…”

Influence of Tinospora cordifolia on wound healing in wistar rats

“…26 On 11 th day after sacrificing the animals the granulation tissue were obtained. The cotton pellets were dried at 60 0 C overnight and the dry weight was recorded to express as mg/100gm body weight.…”

Antioxidant anti-inflammatory activity of Alstonia scholaris R.Br. stem bark extract

“…Sterile preweighed cotton pellets (10 mg) were implanted in the axilla region of each rat through a single needle incision. [6] Methanol extract of Alstonia scholaris stem bark at 200 and 400 mg kg -1 , and its fractions at 25 and 50 mg kg -1 , indomethacin at 10 mg kg -1 (standard) or propylene glycol at 5 mg kg -1 (control) were administered orally to the respective group of animals for seven consecutive days, from the day of cotton-pellet implantation. On the eighth day, the animals were anaesthetized again, the cotton pellets were removed surgically and made free from extraneous tissues.…”